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INCOME TAXES - DEFERRED TAXES (Details) - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Significant components of deferred tax assets      
Net operating loss carryforwards $ 280,400,000 $ 276,100,000  
Research credits 29,800,000 25,000,000  
Capitalized research and development 300,000 1,400,000  
License fees 200,000 300,000  
Other - net 11,500,000 9,800,000  
Total deferred tax assets 322,200,000 312,600,000  
Valuation allowance for deferred tax assets (322,200,000) (312,600,000)  
Valuation allowance      
Increase (decrease) in valuation allowance 9,600,000 $ (2,300,000) $ (3,300,000)
Valuation allowance for deferred tax assets related to benefits of stock option deductions $ 6,400,000