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CONDENSED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Cash flows from operating activities:    
Net loss $ (7,183) $ (8,842)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 20 21
Loss on retirement of property and equipment 5  
Accretion and amortization on investments, net 55 284
Stock-based compensation for services by non-employees 57 50
Stock-based compensation for employees and directors 1,983 2,019
Amortization related to 401(k) contributions 32 53
Changes in assets and liabilities:    
Other current assets (6,003) 813
Other current liabilities 3,727 24
Net cash used in operating activities (7,307) (5,578)
Cash flows from investing activities:    
Purchases of property and equipment   (26)
Purchases of marketable securities (28,282) (46,751)
Proceeds from maturities of marketable securities 37,640 43,083
Net cash provided by (used in) investing activities 9,358 (3,694)
Cash flows from financing activities:    
Proceeds from issuances of common stock   826
Net cash provided by financing activities   826
Net increase (decrease) in cash and cash equivalents 2,051 (8,446)
Cash and cash equivalents at the beginning of the period 12,810 21,248
Cash and cash equivalents at the end of the period 14,861 12,802
Supplemental Disclosure of Non-Cash Investing Activities:    
Net unrealized (loss) gain on marketable securities $ (18) $ 253