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CONDENSED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Cash flows from operating activities:    
Net loss $ (13,588) $ (17,479)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 38 42
Loss on retirement of property and equipment 5  
Accretion and amortization on investments, net 144 439
Stock-based compensation for services by non-employees 115 95
Stock-based compensation for employees and directors 4,058 4,136
Amortization related to 401(k) contributions 32 57
Changes in assets and liabilities:    
Other current assets (5,954) 1,019
Other current liabilities 3,405 477
Net cash used in operating activities (11,745) (11,214)
Cash flows from investing activities:    
Purchases of property and equipment   (26)
Purchases of marketable securities (60,436) (74,110)
Proceeds from maturities of marketable securities 65,940 71,234
Net cash provided by (used in) investing activities 5,504 (2,902)
Cash flows from financing activities:    
Proceeds from issuances of common stock 37 1,067
Net cash provided by financing activities 37 1,067
Net decrease in cash and cash equivalents (6,204) (13,049)
Cash and cash equivalents at the beginning of the period 12,810 21,248
Cash and cash equivalents at the end of the period $ 6,606 $ 8,199