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CONDENSED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Cash flows from operating activities:    
Net loss $ (20,487) $ (21,055)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 57 63
Loss (gain) on retirement/sales of property and equipment 5 (16)
Accretion and amortization on investments, net 213 507
Stock-based compensation for services by non-employees 159 123
Stock-based compensation for employees and directors 6,152 6,263
Amortization related to 401(k) contributions 32 60
Changes in assets and liabilities:    
Other current assets (401) (4,397)
Other current liabilities (1,899) 685
Net cash used in operating activities (16,169) (17,767)
Cash flows from investing activities:    
Restricted cash transfer   (1)
Purchases of property and equipment   (26)
Proceeds from sales of property and equipment   16
Purchases of marketable securities (81,260) (105,698)
Proceeds from maturities of marketable securities 94,486 106,954
Net cash provided by investing activities 13,226 1,245
Cash flows from financing activities:    
Proceeds from issuances of common stock 37 1,157
Net cash provided by financing activities 37 1,157
Net decrease in cash and cash equivalents (2,906) (15,365)
Cash and cash equivalents at the beginning of the period 12,810 21,248
Cash and cash equivalents at the end of the period $ 9,904 $ 5,883