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v3.8.0.1

STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities: |  |  |
Net (loss) income | $ (27,916) | $ (29,537) | $ 46
Adjustments to reconcile net (loss) income to net cash used in operating activities: |  |  |
Depreciation and amortization | 76 | 81 | 56
Loss (gain) on retirement/sales of property and equipment | 5 | (16) |
Accretion and amortization on investments, net | 273 | 552 | 2,098
Loss on sales of marketable securities |  |  | 1
Stock-based compensation for services by non-employees | 200 | 156 | 364
Stock-based compensation for employees and directors | 8,144 | 8,245 | 8,397
Amortization related to 401(k) contributions | 32 | 61 | 161
Unrealized gain on derivatives |  |  | (16)
Changes in assets and liabilities: |  |  |
Interest and other receivables | 39 | 731 | (243)
Prepaid assets | (56) | 123 | 89
Accounts payable | 278 | 65 | (873)
Accrued compensation and benefits | 542 | (183) | (1,187)
Accrued collaboration charges | (1,665) | 1,039 | 2,328
Accrued liabilities | (508) | 314 | (417)
Deferred revenue |  |  | (35,000)
Net cash used in operating activities | (20,556) | (18,369) | (24,196)
Cash flows from investing activities: |  |  |
Restricted cash transfer |  | (1) | (1)
Purchases of property and equipment |  | (57) | (90)
Proceeds from sales of property and equipment |  | 16 |
Purchases of marketable securities | (100,006) | (129,250) | (206,459)
Proceeds from sales/calls of marketable securities |  |  | 4,242
Proceeds from maturities of marketable securities | 122,976 | 138,054 | 202,381
Net cash provided by investing activities | 22,970 | 8,762 | 73
Cash flows from financing activities: |  |  |
Proceeds from issuances of common stock | 1,111 | 1,169 | 2,575
Net cash provided by financing activities | 1,111 | 1,169 | 2,575
Net increase (decrease) in cash and cash equivalents | 3,525 | (8,438) | (21,548)
Cash and cash equivalents at the beginning of the period | 12,810 | 21,248 | 42,796
Cash and cash equivalents at the end of the period | $ 16,335 | $ 12,810 | $ 21,248

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