XML 72 R57.htm IDEA: XBRL DOCUMENT v3.8.0.1
INCOME TAXES - DEFERRED TAXES (Details) - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Significant components of deferred tax assets      
Net operating loss carryforwards $ 187,700,000 $ 280,400,000  
Research credits 34,300,000 29,800,000  
Capitalized research and development 2,500,000 300,000  
License fees 100,000 200,000  
Other-net 8,200,000 11,500,000  
Total deferred tax assets 232,800,000 322,200,000  
Valuation allowance for deferred tax assets (232,800,000) (322,200,000)  
Valuation allowance      
Increase (decrease) in valuation allowance $ (89,400,000) $ 9,600,000 $ (2,300,000)