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CONDENSED STATEMENTS OF CASH FLOW - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Cash flows from operating activities:    
Net loss $ (7,186) $ (7,183)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 16 20
Loss on retirement of property and equipment   5
Accretion and amortization on investments, net 24 55
Change in fair value of equity investment 125  
Stock-based compensation for services by non-employees 71 57
Stock-based compensation for employees and directors 1,614 1,983
Amortization related to 401(k) contributions 10 32
Changes in assets and liabilities:    
Other current and noncurrent assets 89 (6,003)
Other current liabilities (2,131) 3,727
Net cash used in operating activities (7,368) (7,307)
Cash flows from investing activities:    
Purchases of marketable securities (19,768) (28,282)
Proceeds from maturities of marketable securities 17,160 37,640
Net cash (used in) provided by investing activities (2,608) 9,358
Cash flows from financing activities:    
Proceeds from issuances of common stock, net of issuance costs 1,553  
Net cash provided by financing activities 1,553  
Net (decrease) increase in cash, cash equivalents and restricted cash (8,423) 2,051
Cash, cash equivalents and restricted cash at the beginning of the period 16,603 13,078
Cash, cash equivalents and restricted cash at the end of the period $ 8,180 $ 15,129