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STATEMENTS OF OPERATIONS - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
License fees and royalties $ 1,066,000 $ 1,065,000 $ 6,162,000
Operating expenses:      
Research and development 13,432,000 11,033,000 18,047,000
General and administrative 18,707,000 19,287,000 18,761,000
Total operating expenses 32,139,000 30,320,000 36,808,000
Loss from operations (31,073,000) (29,255,000) (30,646,000)
Interest and other income 3,291,000 1,416,000 1,192,000
Gain on settlement 1,460,000    
Change in fair value of equity investment (541,000)    
Other expense (154,000) (77,000) (83,000)
Net loss $ (27,017,000) $ (27,916,000) $ (29,537,000)
Basic and diluted net loss per share $ (0.15) $ (0.18) $ (0.19)
Shares used in computing basic and diluted net loss per share 176,504,996 159,224,986 159,045,644