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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Cash flows from operating activities: |  |
Net loss | $ (10,059) | $ (7,186)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 15 | 16
Accretion and amortization on investments, net | (482) | 24
Change in fair value of equity investment, including foreign currency translation | (103) | 125
Stock-based compensation for services by non-employees | 22 | 71
Stock-based compensation for employees and directors | 1,426 | 1,614
Amortization related to 401(k) contributions | 9 | 10
Changes in assets and liabilities: |  |
Current and noncurrent assets | (1,532) | 89
Current liabilities | (2,034) | (2,131)
Net cash used in operating activities | (12,738) | (7,368)
Cash flows from investing activities: |  |
Purchases of property and equipment | (45) |
Purchases of marketable securities | (44,092) | (19,768)
Proceeds from maturities of marketable securities | 53,101 | 17,160
Net cash provided by (used in) investing activities | 8,964 | (2,608)
Cash flows from financing activities: |  |
Proceeds from issuances of common stock, net of issuance costs |  | 1,553
Net cash provided by financing activities |  | 1,553
Net decrease in cash, cash equivalents and restricted cash | (3,774) | (8,423)
Cash, cash equivalents and restricted cash at the beginning of the period | 10,844 | 16,603
Cash, cash equivalents and restricted cash at the end of the period | $ 7,070 | $ 8,180

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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- Definition Amount of addition (reduction) to the amount at which an asset could be incurred (settled) in a current transaction between willing parties. + References No definition available. + Details
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- Definition Amount of cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; including, but not limited to, disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=98513485&loc=SL98516268-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3521-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3044-108585 + Details
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- Definition Amount of increase (decrease) in cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; excluding effect from exchange rate change. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 830 -SubTopic 230 -Section 45 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=98513438&loc=d3e33268-110906 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3521-108585 + Details
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