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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2019 | Jun. 30, 2018
Cash flows from operating activities: |  |
Net loss | $ (24,298) | $ (14,120)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 26 | 31
Accretion and amortization on investments, net | (958) | (111)
Change in fair value of equity investment, including foreign currency translation | 3 | 513
Stock-based compensation for services by non-employees | 33 | 120
Stock-based compensation for employees and directors | 2,860 | 3,159
Amortization related to 401(k) contributions | 9 | 10
Operating lease expense | 334 |
Changes in assets and liabilities: |  |
Current and noncurrent assets | (386) | 146
Current liabilities | 894 | (1,611)
Net cash used in operating activities | (21,483) | (11,863)
Cash flows from investing activities: |  |
Purchases of property and equipment | (67) |
Purchases of marketable securities | (66,408) | (107,067)
Proceeds from maturities of marketable securities | 94,851 | 37,850
Net cash provided by (used in) investing activities | 28,376 | (69,217)
Cash flows from financing activities: |  |
Proceeds from issuances of common stock, net of issuance costs | 243 | 83,873
Net cash provided by financing activities | 243 | 83,873
Net increase in cash, cash equivalents and restricted cash | 7,136 | 2,793
Cash, cash equivalents and restricted cash at the beginning of the period | 10,844 | 16,603
Cash, cash equivalents and restricted cash at the end of the period | $ 17,980 | $ 19,396

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