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CONDENSED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Gain (Loss)
--- | --- | --- | --- | --- | ---
Balances at Dec. 31, 2017 | $ 103,797 | $ 160 | $ 1,089,684 | $ (985,840) | $ (207)
Balances (in shares) at Dec. 31, 2017 |  | 159,877,239 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Cumulative effect of accounting principle change | 1,393 |  |  | 1,393 |
Net loss | (7,186) |  |  | (7,186) |
Other comprehensive income (loss) | (124) |  |  |  | (124)
Issuance of common stock in connection with at market offering, net of issuance costs | 1,553 | $ 1 | 1,552 |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  | 776,788 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 71 |  | 71 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 8,308 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,614 |  | 1,614 |  |
401(k) contribution | 10 |  | 10 |  |
Balances at Mar. 31, 2018 | 101,128 | $ 161 | 1,092,931 | (991,633) | (331)
Balances (in shares) at Mar. 31, 2018 |  | 160,662,335 |  |  |
Balances at Dec. 31, 2017 | 103,797 | $ 160 | 1,089,684 | (985,840) | (207)
Balances (in shares) at Dec. 31, 2017 |  | 159,877,239 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (19,717) |  |  |  |
Other comprehensive income (loss) | 95 |  |  |  |
Balances at Sep. 30, 2018 | 183,467 | $ 186 | 1,187,557 | (1,004,164) | (112)
Balances (in shares) at Sep. 30, 2018 |  | 186,348,066 |  |  |
Balances at Mar. 31, 2018 | 101,128 | $ 161 | 1,092,931 | (991,633) | (331)
Balances (in shares) at Mar. 31, 2018 |  | 160,662,335 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (6,934) |  |  | (6,934) |
Other comprehensive income (loss) | 254 |  |  |  | 254
Issuance of common stock in connection with at market offering, net of issuance costs | 82,306 | $ 22 | 82,284 |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  | 21,865,344 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 49 |  | 49 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 10,295 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,545 |  | 1,545 |  |
Issuance of common stock under equity plans | 14 |  | 14 |  |
Issuances of common stock under equity plans (in shares) |  | 9,097 |  |  |
Balances at Jun. 30, 2018 | 178,362 | $ 183 | 1,176,823 | (998,567) | (77)
Balances (in shares) at Jun. 30, 2018 |  | 182,547,071 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (5,597) |  |  | (5,597) |
Other comprehensive income (loss) | (35) |  |  |  | (35)
Issuance of common stock in connection with at market offering, net of issuance costs | 2,158 |  | 2,158 |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  | 636,053 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 35 |  | 35 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 20,064 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,615 |  | 1,615 |  |
Issuance of common stock under equity plans | 6,929 | $ 3 | 6,926 |  |
Issuances of common stock under equity plans (in shares) |  | 3,144,878 |  |  |
Balances at Sep. 30, 2018 | 183,467 | $ 186 | 1,187,557 | (1,004,164) | (112)
Balances (in shares) at Sep. 30, 2018 |  | 186,348,066 |  |  |
Balances at Dec. 31, 2018 | 177,733 | $ 186 | 1,189,194 | (1,011,464) | (183)
Balances (in shares) at Dec. 31, 2018 |  | 186,392,682 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (10,059) |  |  | (10,059) |
Other comprehensive income (loss) | 282 |  |  |  | 282
Stock-based compensation related to issuance of common stock and options in exchange for services | 22 |  | 22 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 13,365 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,426 |  | 1,426 |  |
401(k) contribution | 9 |  | 9 |  |
Balances at Mar. 31, 2019 | 169,413 | $ 186 | 1,190,651 | (1,021,523) | 99
Balances (in shares) at Mar. 31, 2019 |  | 186,406,047 |  |  |
Balances at Dec. 31, 2018 | 177,733 | $ 186 | 1,189,194 | (1,011,464) | (183)
Balances (in shares) at Dec. 31, 2018 |  | 186,392,682 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (39,478) |  |  |  |
Other comprehensive income (loss) | 422 |  |  |  |
Balances at Sep. 30, 2019 | 152,392 | $ 193 | 1,202,902 | (1,050,942) | 239
Balances (in shares) at Sep. 30, 2019 |  | 192,865,094 |  |  |
Balances at Mar. 31, 2019 | 169,413 | $ 186 | 1,190,651 | (1,021,523) | 99
Balances (in shares) at Mar. 31, 2019 |  | 186,406,047 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (14,239) |  |  | (14,239) |
Other comprehensive income (loss) | 182 |  |  |  | 182
Issuance of common stock in connection with at market offering, net of issuance costs | 101 |  | 101 |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  | 108,386 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 11 |  | 11 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 5,097 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,434 |  | 1,434 |  |
Issuance of common stock under equity plans | 142 | $ 1 | 141 |  |
Issuances of common stock under equity plans (in shares) |  | 118,871 |  |  |
Balances at Jun. 30, 2019 | 157,044 | $ 187 | 1,192,338 | (1,035,762) | 281
Balances (in shares) at Jun. 30, 2019 |  | 186,638,401 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (15,180) |  |  | (15,180) |
Other comprehensive income (loss) | (42) |  |  |  | (42)
Issuance of common stock in connection with at market offering, net of issuance costs | 8,959 | $ 6 | 8,953 |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  | 6,197,956 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 17 |  | 17 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 5,404 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,569 |  | 1,569 |  |
Issuance of common stock under equity plans | 25 |  | 25 |  |
Issuances of common stock under equity plans (in shares) |  | 23,333 |  |  |
Balances at Sep. 30, 2019 | $ 152,392 | $ 193 | $ 1,202,902 | $ (1,050,942) | $ 239
Balances (in shares) at Sep. 30, 2019 |  | 192,865,094 |  |  |

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