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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Cash flows from operating activities: |  |
Net loss | $ (39,478) | $ (19,717)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 35 | 45
Accretion and amortization on investments, net | (1,283) | (521)
Change in fair value of equity investment, including foreign currency translation | 212 | 338
Stock-based compensation for services by non-employees | 50 | 155
Stock-based compensation for employees and directors | 4,429 | 4,774
Amortization related to 401(k) contributions | 9 | 10
Operating lease expense | 504 |
Changes in assets and liabilities: |  |
Current and noncurrent assets | (1,399) | (1,034)
Current liabilities | 3,458 | (2,049)
Net cash used in operating activities | (33,463) | (17,999)
Cash flows from investing activities: |  |
Purchases of property and equipment | (324) | (9)
Purchases of marketable securities | (102,276) | (149,720)
Proceeds from maturities of marketable securities | 137,013 | 71,163
Net cash provided by (used in) investing activities | 34,413 | (78,566)
Cash flows from financing activities: |  |
Proceeds from issuances of common stock, net of issuance costs | 9,227 | 92,960
Net cash provided by financing activities | 9,227 | 92,960
Net increase (decrease) in cash, cash equivalents and restricted cash | 10,177 | (3,605)
Cash, cash equivalents and restricted cash at the beginning of the period | 10,844 | 16,603
Cash, cash equivalents and restricted cash at the end of the period | $ 21,021 | $ 12,998

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