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STATEMENTS OF OPERATIONS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Revenues: |  |  |
License fees and royalties | $ 460,000 | $ 1,066,000 | $ 1,065,000
Operating expenses: |  |  |
Research and development | 52,072,000 | 13,432,000 | 11,033,000
General and administrative | 20,893,000 | 18,707,000 | 19,287,000
Total operating expenses | 72,965,000 | 32,139,000 | 30,320,000
Loss from operations | (72,505,000) | (31,073,000) | (29,255,000)
Interest and other income | 4,221,000 | 3,291,000 | 1,416,000
Gain on settlement |  | 1,460,000 |
Change in fair value of equity investment | (195,000) | (541,000) |
Other expense | (69,000) | (154,000) | (77,000)
Net loss | $ (68,548,000) | $ (27,017,000) | $ (27,916,000)
Basic and diluted net loss per share | $ (0.36) | $ (0.15) | $ (0.18)
Shares used in computing basic and diluted net loss per share | 190,160,311 | 176,504,996 | 159,224,986

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