STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Cash flows from operating activities:
Net loss	$ (68,548)	$ (27,017)	$ (27,916)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	64	59	76
Loss on retirement/sales of property and equipment			5
Accretion and amortization on investments, net	(1,534)	(978)	273
Change in fair value of equity investment, including foreign currency translation	196	604
Stock-based compensation for services by non-employees	68	191	200
Stock-based compensation for employees and directors	6,079	6,368	8,144
Amortization related to 401(k) contributions	9	9	32
Amortization of right-of use-assets	712
Changes in assets and liabilities:
Interest and other receivables	366	(528)	39
Prepaid assets	121	(752)	(56)
Deposit and other assets	(964)
Accounts payable	199	479	278
Accrued compensation and benefits	2,188	(743)	542
Amount due to Janssen Biotech, Inc.	11,659	908	(1,665)
Accrued liabilities	6,211	391	(508)
Operating lease liabilities	(655)
Net cash used in operating activities	(43,829)	(21,009)	(20,556)
Cash flows from investing activities:
Purchases of property and equipment	(413)	(16)
Purchases of marketable securities	(153,467)	(188,365)	(100,006)
Proceeds from maturities of marketable securities	181,280	110,663	122,976
Net cash provided by (used in) investing activities	27,400	(77,718)	22,970
Cash flows from financing activities:
Proceeds from issuances of common stock under equity plans	204	6,951	51
Proceeds from issuances of common stock from financings	19,295	86,017	1,060
Net cash provided by financing activities	19,499	92,968	1,111
Net increase (decrease) in cash, cash equivalents and restricted cash	3,070	(5,759)	3,525
Cash, cash equivalents and restricted cash at the beginning of the period	10,844	16,603	13,078
Cash, cash equivalents and restricted cash at the end of the period	$ 13,914	$ 10,844	$ 16,603

The increase (decrease) during the reporting period for amount due to counterparty.

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