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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Cumulative Effect, Period of Adoption, Adjustment | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment | Accumulated Other Comprehensive Gain (Loss)
--- | --- | --- | --- | --- | --- | --- | ---
Balances at Dec. 31, 2017 | $ 103,797 | $ 1,393 | $ 160 | $ 1,089,684 | $ (985,840) | $ 1,393 | $ (207)
Balances (in shares) at Dec. 31, 2017 |  |  | 159,877,239 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |
Net loss | (27,017) |  |  |  | (27,017) |  |
Other comprehensive (loss) income | 24 |  |  |  |  |  | 24
Issuance of common stock in connection with at market offering, net of issuance costs | 86,017 |  | $ 23 | 85,994 |  |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  |  | 23,278,185 |  |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 191 |  |  | 191 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  |  | 73,980 |  |  |  |
Issuances of common stock under equity plans | 6,951 |  | $ 3 | 6,948 |  |  |
Issuances of common stock under equity plans (in shares) |  |  | 3,163,278 |  |  |  |
Stock-based compensation for equity- based awards to employees and directors | 6,368 |  |  | 6,368 |  |  |
401(k) contribution | 9 |  |  | 9 |  |  |
Balances at Dec. 31, 2018 | 177,733 |  | $ 186 | 1,189,194 | (1,011,464) |  | (183)
Balances (in shares) at Dec. 31, 2018 |  |  | 186,392,682 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |
Net loss | (68,548) |  |  |  | (68,548) |  |
Other comprehensive (loss) income | 315 |  |  |  |  |  | 315
Issuance of common stock in connection with at market offering, net of issuance costs | 19,295 |  | $ 14 | 19,281 |  |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  |  | 13,214,867 |  |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 68 |  |  | 68 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  |  | 29,150 |  |  |  |
Issuances of common stock under equity plans | 204 |  |  | 204 |  |  |
Issuances of common stock under equity plans (in shares) |  |  | 177,882 |  |  |  |
Stock-based compensation for equity- based awards to employees and directors | 6,079 |  |  | 6,079 |  |  |
401(k) contribution | 9 |  |  | 9 |  |  |
Balances at Dec. 31, 2019 | $ 135,155 |  | $ 200 | 1,214,835 | (1,080,012) |  | 132
Balances (in shares) at Dec. 31, 2019 | 199,814,581 |  | 199,814,581 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |
Net loss | $ (75,617) |  |  |  | (75,617) |  |
Other comprehensive (loss) income | (54) |  |  |  |  |  | (54)
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs | 140,184 |  | $ 107 | 140,077 |  |  |
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs (in shares) |  |  | 107,049,375 |  |  |  |
Issuance of common stock in connection with at market offering, net of issuance costs | 4,075 |  | $ 3 | 4,072 |  |  |
Issuance of common stock in connection with at market offering, net of issuance costs (in shares) |  |  | 3,496,616 |  |  |  |
Issuance of common stock in connection exercise of warrants | 16 |  |  | 16 |  |  |
Issuance of common stock in connection exercise of warrants (in shares) |  |  | 12,500 |  |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 85 |  |  | 85 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  |  | 17,986 |  |  |  |
Issuances of common stock under equity plans | 208 |  |  | 208 |  |  |
Issuances of common stock under equity plans (in shares) |  |  | 175,795 |  |  |  |
Stock-based compensation for equity- based awards to employees and directors | 6,895 |  |  | 6,895 |  |  |
Balances at Dec. 31, 2020 | $ 210,947 |  | $ 310 | $ 1,366,188 | $ (1,155,629) |  | $ 78
Balances (in shares) at Dec. 31, 2020 | 310,566,853 |  | 310,566,853 |  |  |  |

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