STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenues:
License fees and royalties	$ 253	$ 460	$ 1,066
Operating expenses:
Research and development	51,488	52,072	13,432
General and administrative	25,678	20,893	18,707
Total operating expenses	77,166	72,965	32,139
Loss from operations	(76,913)	(72,505)	(31,073)
Interest income	1,828	4,221	3,251
Interest expense	(760)
Change in fair value of equity investment	60	(195)	(541)
Gain on settlement			1,460
Other income and (expense), net	168	(69)	(114)
Net loss	$ (75,617)	$ (68,548)	$ (27,017)
Basic and diluted net loss per share	$ (0.28)	$ (0.36)	$ (0.15)
Shares used in computing basic and diluted net loss per share	271,460,265	190,160,311	176,504,996

The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 7
-URI http://asc.fasb.org/extlink&oid=121326447&loc=d3e1337-109256