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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Cumulative Effect, Period of Adoption, Adjustment
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Deficit
Cumulative Effect, Period of Adoption, Adjustment
Accumulated Other Comprehensive Gain (Loss)
Balances at Dec. 31, 2017 $ 103,797 $ 1,393 $ 160 $ 1,089,684 $ (985,840) $ 1,393 $ (207)
Balances (in shares) at Dec. 31, 2017     159,877,239        
Increase (Decrease) in Stockholders' Equity              
Net loss (27,017)       (27,017)    
Other comprehensive (loss) income 24           24
Issuance of common stock in connection with at market offering, net of issuance costs 86,017   $ 23 85,994      
Issuance of common stock in connection with at market offering, net of issuance costs (in shares)     23,278,185        
Stock-based compensation related to issuance of common stock and options in exchange for services 191     191      
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)     73,980        
Issuances of common stock under equity plans 6,951   $ 3 6,948      
Issuances of common stock under equity plans (in shares)     3,163,278        
Stock-based compensation for equity- based awards to employees and directors 6,368     6,368      
401(k) contribution 9     9      
Balances at Dec. 31, 2018 177,733   $ 186 1,189,194 (1,011,464)   (183)
Balances (in shares) at Dec. 31, 2018     186,392,682        
Increase (Decrease) in Stockholders' Equity              
Net loss (68,548)       (68,548)    
Other comprehensive (loss) income 315           315
Issuance of common stock in connection with at market offering, net of issuance costs 19,295   $ 14 19,281      
Issuance of common stock in connection with at market offering, net of issuance costs (in shares)     13,214,867        
Stock-based compensation related to issuance of common stock and options in exchange for services 68     68      
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)     29,150        
Issuances of common stock under equity plans 204     204      
Issuances of common stock under equity plans (in shares)     177,882        
Stock-based compensation for equity- based awards to employees and directors 6,079     6,079      
401(k) contribution 9     9      
Balances at Dec. 31, 2019 $ 135,155   $ 200 1,214,835 (1,080,012)   132
Balances (in shares) at Dec. 31, 2019 199,814,581   199,814,581        
Increase (Decrease) in Stockholders' Equity              
Net loss $ (75,617)       (75,617)    
Other comprehensive (loss) income (54)           (54)
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs 140,184   $ 107 140,077      
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs (in shares)     107,049,375        
Issuance of common stock in connection with at market offering, net of issuance costs 4,075   $ 3 4,072      
Issuance of common stock in connection with at market offering, net of issuance costs (in shares)     3,496,616        
Issuance of common stock in connection exercise of warrants 16     16      
Issuance of common stock in connection exercise of warrants (in shares)     12,500        
Stock-based compensation related to issuance of common stock and options in exchange for services 85     85      
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)     17,986        
Issuances of common stock under equity plans 208     208      
Issuances of common stock under equity plans (in shares)     175,795        
Stock-based compensation for equity- based awards to employees and directors 6,895     6,895      
Balances at Dec. 31, 2020 $ 210,947   $ 310 $ 1,366,188 $ (1,155,629)   $ 78
Balances (in shares) at Dec. 31, 2020 310,566,853   310,566,853