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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash flows from operating activities: |  |
Net loss | $ (84,095) | $ (51,830)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 154 | 109
Accretion and amortization on investments, net | 1,137 | 387
Amortization of debt issuance costs/debt discounts | 627 |
Gain on sale of marketable securities |  | (19)
Gain on sales of equity investment | (1,233) | (148)
Change in fair value of equity investment, including foreign currency translation |  | (187)
Stock-based compensation for services by non-employees | 71 | 54
Stock-based compensation for employees and directors | 5,775 | 5,043
Amortization of right-of-use assets | 403 | 647
Changes in assets and liabilities: |  |
Current and noncurrent assets | (3,363) | (2,563)
Amount due to Janssen Biotech, Inc. |  | (14,269)
Current and noncurrent liabilities | 7,136 | 8,738
Net cash used in operating activities | (73,388) | (54,038)
Cash flows from investing activities: |  |
Purchases of property and equipment | (104) | (390)
Purchases of marketable securities | (116,482) | (220,066)
Proceeds from sale of marketable securities |  | 7,681
Proceeds from maturities of marketable securities | 178,574 | 128,952
Proceeds from sales of equity investment | 1,594 | 339
Net cash provided by (used in) investing activities | 63,582 | (83,484)
Cash flows from financing activities: |  |
Proceeds from issuances of common stock from equity plans | 204 | 97
Proceeds from issuance of common stock and warrants in public offering, net of paid issuance costs |  | 140,184
Proceeds from issuances of common stock from at market offerings, net of paid issuance costs | 16,234 | 4,075
Proceeds from exercise of warrants | 2,479 | 16
Proceeds from debt financing, net of paid debt issuance costs and debt discounts | 10,000 | 24,555
Net cash provided by financing activities | 28,917 | 168,927
Net increase in cash, cash equivalents and restricted cash | 19,111 | 31,405
Cash, cash equivalents and restricted cash at the beginning of the period | 10,288 | 13,914
Cash, cash equivalents and restricted cash at the end of the period | $ 29,399 | $ 45,319

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