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INCOME TAXES - DEFERRED TAXES (Details) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Significant components of deferred tax assets |  |
Net operating loss carryforwards | $ 241,300,000 | $ 217,100,000
Federal and state tax credits | 49,600,000 | 42,800,000
Capitalized research and development | 6,900,000 | 6,000,000
Stock-based compensation | 10,200,000 | 9,400,000
Operating lease liabilities | 1,400,000 | 1,200,000
Other | 2,600,000 | 2,100,000
Total deferred tax assets | 312,000,000 | 278,600,000
Less: valuation allowance | (310,700,000) | (277,200,000)
Net deferred tax assets | 1,300,000 | 1,400,000
Operating leases, right-of-use assets | (1,300,000) | (1,400,000)
Total deferred tax liabilities | (1,300,000) | (1,400,000)
Valuation allowance |  |
Increase (decrease) in valuation allowance | $ 33,500,000 | $ 19,300,000

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