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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Cash flows from operating activities: |  |
Net loss | $ (58,215) | $ (57,398)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 129 | 101
Accretion and amortization on investments, net | 304 | 778
Amortization of debt issuance costs/debt discount | 704 | 374
Gain on sales of equity investment |  | (1,233)
Stock-based compensation for services by non-employees | 28 | 48
Stock-based compensation for employees and directors | 3,750 | 3,767
Amortization of right-of-use assets | 285 | 266
Changes in assets and liabilities: |  |
Current and noncurrent assets | (5,507) | (3,042)
Current and noncurrent liabilities | (4,094) | 5,791
Net cash used in operating activities | (62,616) | (50,548)
Cash flows from investing activities: |  |
Purchases of property and equipment | (120) | (10)
Purchases of marketable securities | (57,049) | (82,430)
Proceeds from maturities of marketable securities | 90,406 | 149,834
Proceeds from sales of equity investment |  | 1,594
Net cash provided by investing activities | 33,237 | 68,988
Cash flows from financing activities: |  |
Proceeds from issuances of common stock from equity plans | 761 | 204
Proceeds from issuance of common stock and warrants in public offering, net of paid issuance costs | 69,916 |
Proceeds from issuances of common stock from at market offerings, net of paid issuance costs |  | 16,234
Proceeds from exercise of warrants |  | 2,479
Proceeds from debt financing |  | 10,000
Debt discount and issuance costs for debt financing | (114) |
Net cash provided by financing activities | 70,563 | 28,917
Net effect of unrealized losses and exchange rates on cash, cash equivalents and restricted cash | 2 |
Net change in cash, cash equivalents and restricted cash | 41,186 | 47,357
Cash, cash equivalents and restricted cash at the beginning of the period | 35,235 | 10,288
Cash, cash equivalents and restricted cash at the end of the period | $ 76,421 | $ 57,645

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- Definition Amount of increase (decrease) from effect of unrealized losses and exchange rate changes on cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; held in foreign currencies; including, but not limited to, disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References No definition available. + Details
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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3602-108585 + Details
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