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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |  |
Net loss | $ (141,901) | $ (116,112) | $ (75,617)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 288 | 215 | 158
Accretion and amortization on investments, net | (965) | 1,424 | 818
Amortization of debt issuance costs/debt discount | 1,327 | 893 | 179
Gain on sales of available for sale securities |  |  | (19)
Net gain on exchange and sales of equity investment |  | (1,233) | (148)
Change in fair value of equity investment, including foreign currency translation |  |  | (163)
Stock-based compensation for services by non-employees | 264 | 91 | 85
Stock-based compensation for employees and directors | 8,001 | 8,080 | 6,895
Amortization of right-of-use assets | 580 | 568 | 777
Changes in assets and liabilities: |  |  |
Interest and other receivables | (1,381) | (1,041) | 80
Prepaid and other current assets | (2,630) | 1,317 | (1,286)
Deposit and other assets | (594) | (3,807) | (206)
Accounts payable | 3,503 | (232) | 5,731
Accrued compensation and benefits | 3,435 | (119) | 3,388
Amount due to Janssen Biotech, Inc. |  |  | (14,269)
Accrued liabilities | 3,266 | 14,909 | 7,397
Operating lease liabilities | (572) | (509) | (452)
Net cash used in operating activities | (127,379) | (95,556) | (66,652)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (431) | (207) | (401)
Purchases of marketable securities | (258,007) | (177,434) | (313,201)
Proceeds from sales of securities available for sale |  |  | 7,681
Proceeds from maturities of marketable securities | 320,505 | 247,994 | 200,262
Proceeds from sales of equity investment |  | 1,594 | 339
Net cash provided by (used in) investing activities | 62,067 | 71,947 | (105,320)
Cash flows from financing activities: |  |  |
Proceeds from issuances of common stock from equity plans | 2,185 | 797 | 208
Proceeds from issuance of common stock and warrants in public offering, net of paid issuance costs | 69,916 |  | 140,184
Proceeds from issuances of common stock from at market offerings, net of paid issuance costs |  | 20,385 | 4,075
Proceeds from exercise of warrants | 15,163 | 2,479 | 16
Proceeds from debt financing, net of paid debt issuance costs and debt discounts |  | 24,895 | 23,863
Net cash provided by financing activities | 87,264 | 48,556 | 168,346
Net effect of unrealized gains and exchange rates on cash, cash equivalents and restricted cash | 22 |  |
Net increase (decrease) in cash, cash equivalents and restricted cash | 21,974 | 24,947 | (3,626)
Cash, cash equivalents and restricted cash at the beginning of the period | 35,235 | 10,288 | 13,914
Cash, cash equivalents and restricted cash at the end of the period | $ 57,209 | $ 35,235 | $ 10,288

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- Definition Amount of increase (decrease) from effect of unrealized losses and exchange rate changes on cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; held in foreign currencies; including, but not limited to, disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References No definition available. + Details
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