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FAIR VALUE MEASUREMENTS | 12 Months Ended
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Dec. 31, 2022
Fair Value Disclosures [Abstract] |
FAIR VALUE MEASUREMENTS | 2. FAIR VALUE MEASUREMENTS Cash Equivalents and Marketable Securities Cash equivalents, restricted cash and marketable securities by security type at December 31, 2022 were as follows:
|  |  |  |  | Gross |  |  | Gross |  |  |  |
|  | Amortized |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
(In thousands) |  | Cost |  |  | Gains |  |  | Losses |  |  | Fair Value |
Included in cash and cash equivalents: |  |  |  |  |  |  |  |  |  |  |  |
Money market funds |  | $ | 39,771 |  |  | $ | — |  |  | $ | — |  |  | $ | 39,771 |
|  | $ | 39,771 |  |  | $ | — |  |  | $ | — |  |  | $ | 39,771 |
Restricted cash: |  |  |  |  |  |  |  |  |  |  |  |
Money market fund |  | $ | 93 |  |  | $ | — |  |  | $ | — |  |  | $ | 93 |
Certificate of deposit |  |  | 271 |  |  |  | — |  |  |  | — |  |  |  | 271 |
|  | $ | 364 |  |  | $ | — |  |  | $ | — |  |  | $ | 364 |
Marketable securities: |  |  |  |  |  |  |  |  |  |  |  |
U.S. Treasury securities (due in less than one year) |  | $ | 12,983 |  |  | $ | — |  |  | $ | (62 | ) |  | $ | 12,921 |
Municipal securities (due in less than one year) |  |  | 3,000 |  |  |  | — |  |  |  | (24 | ) |  |  | 2,976 |
Government-sponsored enterprise securities (due in less than one year) |  |  | 9,860 |  |  |  | — |  |  |  | (14 | ) |  |  | 9,846 |
Commercial paper (due in less than one year) |  |  | 64,285 |  |  |  | 6 |  |  |  | (92 | ) |  |  | 64,199 |
Corporate notes (due in less than one year) |  |  | 26,014 |  |  |  | — |  |  |  | (55 | ) |  |  | 25,959 |
|  | $ | 116,142 |  |  | $ | 6 |  |  | $ | (247 | ) |  | $ | 115,901 |
Cash equivalents, restricted cash and marketable securities by security type at December 31, 2021 were as follows:
|  |  |  |  | Gross |  |  | Gross |  |  |  |
|  | Amortized |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
(In thousands) |  | Cost |  |  | Gains |  |  | Losses |  |  | Fair Value |
Included in cash and cash equivalents: |  |  |  |  |  |  |  |  |  |  |  |
Money market funds |  | $ | 24,207 |  |  | $ | — |  |  | $ | — |  |  | $ | 24,207 |
Commercial paper |  |  | 7,499 |  |  |  | — |  |  |  | — |  |  |  | 7,499 |
|  | $ | 31,706 |  |  | $ | — |  |  | $ | — |  |  | $ | 31,706 |
Restricted cash: |  |  |  |  |  |  |  |  |  |  |  |
Money market fund |  | $ | 93 |  |  | $ | — |  |  | $ | — |  |  | $ | 93 |
Certificate of deposit |  |  | 271 |  |  |  | — |  |  |  | — |  |  |  | 271 |
|  | $ | 364 |  |  | $ | — |  |  | $ | — |  |  | $ | 364 |
Marketable securities: |  |  |  |  |  |  |  |  |  |  |  |
U.S. Treasury securities (due in less than one year) |  | $ | 15,585 |  |  | $ | — |  |  | $ | (18 | ) |  | $ | 15,567 |
U.S. Treasury securities (due in one to two years) |  |  | 1,524 |  |  |  | — |  |  |  | (3 | ) |  |  | 1,521 |
Municipal securities (due in one to two years) |  |  | 3,000 |  |  |  | — |  |  |  | (15 | ) |  |  | 2,985 |
Government-sponsored enterprise securities (due in less than one year) |  |  | 12,500 |  |  |  | — |  |  |  | (7 | ) |  |  | 12,493 |
Commercial paper (due in less than one year) |  |  | 84,398 |  |  |  | 2 |  |  |  | (38 | ) |  |  | 84,362 |
Corporate notes (due in less than one year) |  |  | 36,444 |  |  |  | 2 |  |  |  | (17 | ) |  |  | 36,429 |
Corporate notes (due in one to two years) |  |  | 24,224 |  |  |  | — |  |  |  | (79 | ) |  |  | 24,145 |
|  | $ | 177,675 |  |  | $ | 4 |  |  | $ | (177 | ) |  | $ | 177,502 |
Cash equivalents and marketable securities with unrealized losses that have been in a continuous unrealized loss position for less than 12 months and 12 months or longer at December 31, 2022 and 2021 were as follows:
|  | Less Than 12 Months |  |  | 12 Months or Greater |  |  | Total |
|  |  |  |  | Gross |  |  |  |  |  | Gross |  |  |  |  |  | Gross |
|  | Estimated |  |  | Unrealized |  |  | Estimated |  |  | Unrealized |  |  | Estimated |  |  | Unrealized |
(In thousands) |  | Fair Value |  |  | Losses |  |  | Fair Value |  |  | Losses |  |  | Fair Value |  |  | Losses |
As of December 31, 2022: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
U.S. Treasury securities (due in less than one year) |  | $ | 11,424 |  |  | $ | (57 | ) |  | $ | 1,497 |  |  | $ | (5 | ) |  | $ | 12,921 |  |  | $ | (62 | )
Municipal securities (due in less than a year) |  |  | — |  |  |  | — |  |  |  | 2,976 |  |  |  | (24 | ) |  |  | 2,976 |  |  |  | (24 | )
Government-sponsored enterprise securities (due in less than one year) |  |  | 9,845 |  |  |  | (14 | ) |  |  | — |  |  |  | — |  |  |  | 9,845 |  |  |  | (14 | )
Commercial paper (due in less than one year) |  |  | 52,454 |  |  |  | (92 | ) |  |  | — |  |  |  | — |  |  |  | 52,454 |  |  |  | (92 | )
Corporate notes (due in less than one year) |  |  | 1,998 |  |  |  | (2 | ) |  |  | 23,962 |  |  |  | (53 | ) |  |  | 25,960 |  |  |  | (55 | )
|  | $ | 75,721 |  |  | $ | (165 | ) |  | $ | 28,435 |  |  | $ | (82 | ) |  | $ | 104,156 |  |  | $ | (247 | )
As of December 31, 2021: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
U.S. Treasury securities (due in less than one year) |  | $ | 15,567 |  |  | $ | (18 | ) |  | $ | — |  |  | $ | — |  |  | $ | 15,567 |  |  | $ | (18 | )
U.S. Treasury securities (due in one to two years) |  |  | 1,521 |  |  |  | (3 | ) |  |  | — |  |  |  | — |  |  |  | 1,521 |  |  |  | (3 | )
Municipal securities (due in one to two years) |  |  | 2,985 |  |  |  | (15 | ) |  |  | — |  |  |  | — |  |  |  | 2,985 |  |  |  | (15 | )
Government-sponsored enterprise securities (due in less than one year) |  |  | 1,500 |  |  |  | — |  |  |  | 4,993 |  |  |  | (7 | ) |  |  | 6,493 |  |  |  | (7 | )
Commercial paper (due in less than one year) |  |  | 66,872 |  |  |  | (38 | ) |  |  | — |  |  |  | — |  |  |  | 66,872 |  |  |  | (38 | )
Corporate notes (due in less than one year) |  |  | 16,001 |  |  |  | (17 | ) |  |  | — |  |  |  | — |  |  |  | 16,001 |  |  |  | (17 | )
Corporate notes (due in one to two years) |  |  | 24,145 |  |  |  | (79 | ) |  |  | — |  |  |  | — |  |  |  | 24,145 |  |  |  | (79 | )
|  | $ | 128,591 |  |  | $ | (170 | ) |  | $ | 4,993 |  |  | $ | (7 | ) |  | $ | 133,584 |  |  | $ | (177 | )
The gross unrealized losses related to U.S. Treasury securities, municipal securities, government-sponsored enterprise securities, commercial paper and corporate notes as of December 31, 2022 and 2021 were due to changes in interest rates and not credit risk. We determined that the gross unrealized losses on our cash equivalents and marketable securities as of December 31, 2022 and 2021 were temporary in nature. Our exposure to unrealized losses may increase in the future due to the economic pressures or uncertainties associated with local or global economic recessions as a result of the ongoing COVID-19 pandemic and ongoing geopolitical events, such as the current military conflict between Ukraine and Russia, as well as recent and potential future disruptions in access to bank deposits or lending commitments due to bank failure. We review our investments quarterly to identify and evaluate whether any investments have indications of possible other-than-temporary impairment. Factors considered in determining whether a loss is temporary include the length of time and extent to which the fair value has been less than the amortized cost basis and whether we intend to sell the security or whether it is more likely than not that we would be required to sell the security before recovery of the amortized cost basis. We currently do not intend to sell these securities before recovery of their amortized cost bases. Fair Value on a Recurring Basis We categorize financial instruments recorded at fair value on our consolidated balance sheets based upon the level of judgment associated with inputs used to measure their fair value. The categories are as follows:
| Level 1 | — | Inputs are unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date. An active market for the asset or liability is a market in which transactions for the asset or liability occur with sufficient frequency and volume to provide pricing information on an ongoing basis.
| Level 2 | — | Inputs (other than quoted market prices included in Level 1) are either directly or indirectly observable for the asset or liability through correlation with market data at the measurement date and for the duration of the instrument’s anticipated life.
| Level 3 | — | Inputs reflect management’s best estimate of what market participants would use in pricing the asset or liability at the measurement date. Consideration is given to the risk inherent in the valuation technique and the risk inherent in the inputs to the model.
A financial instrument’s categorization within the valuation hierarchy is based upon the lowest level of input that is significant to the fair value measurement. Below is a description of the valuation methodologies used for financial instruments measured at fair value on our consolidated balance sheets, including the category for such financial instruments. Money market funds and certificates of deposit are categorized as Level 1 within the fair value hierarchy as their fair values are based on quoted prices available in active markets. Commercial paper, U.S. Treasury securities, municipal securities, government-sponsored enterprise securities and corporate notes are categorized as Level 2 within the fair value hierarchy as their fair values are estimated by using pricing models, quoted prices of securities with similar characteristics or discounted cash flows. The following table presents information about our financial instruments that are measured at fair value on a recurring basis as of December 31, 2022 and 2021 and indicates the fair value category assigned.
|  | Fair Value Measurements at Reporting Date Using |
|  | Quoted Prices in |  |  |  |  |  | Significant |  |  |  |
|  | Active Markets for |  |  | Significant Other |  |  | Unobservable |  |  |  |
|  | Identical Assets |  |  | Observable Inputs |  |  | Inputs |  |  |  |
(In thousands) |  | Level 1 |  |  | Level 2 |  |  | Level 3 |  |  | Total |
As of December 31, 2022: |  |  |  |  |  |  |  |  |  |  |  |
Money market funds(1)(2) |  | $ | 39,864 |  |  | $ | — |  |  | $ | — |  |  | $ | 39,864 |
Certificate of deposit(2) |  |  | 271 |  |  |  | — |  |  |  | — |  |  |  | 271 |
U.S. Treasury securities(3) |  |  | — |  |  |  | 12,921 |  |  |  | — |  |  |  | 12,921 |
Municipal securities(3) |  |  | — |  |  |  | 2,976 |  |  |  | — |  |  |  | 2,976 |
Government-sponsored enterprise securities(3) |  |  | — |  |  |  | 9,846 |  |  |  | — |  |  |  | 9,846 |
Commercial paper(3) |  |  | — |  |  |  | 64,199 |  |  |  | — |  |  |  | 64,199 |
Corporate notes(3) |  |  | — |  |  |  | 25,959 |  |  |  | — |  |  |  | 25,959 |
Total |  | $ | 40,135 |  |  | $ | 115,901 |  |  | $ | — |  |  | $ | 156,036 |
As of December 31, 2021: |  |  |  |  |  |  |  |  |  |  |  |
Money market funds(1) |  | $ | 24,207 |  |  | $ | — |  |  | $ | — |  |  | $ | 24,207 |
U.S. Treasury securities(3)(4) |  |  | — |  |  |  | 17,088 |  |  |  | — |  |  |  | 17,088 |
Municipal securities(4) |  |  | — |  |  |  | 2,985 |  |  |  | — |  |  |  | 2,985 |
Government-sponsored enterprise securities(3) |  |  | — |  |  |  | 12,493 |  |  |  | — |  |  |  | 12,493 |
Commercial paper(1)(3) |  |  | — |  |  |  | 91,861 |  |  |  | — |  |  |  | 91,861 |
Corporate notes(3)(4) |  |  | — |  |  |  | 60,574 |  |  |  | — |  |  |  | 60,574 |
Total |  | $ | 24,207 |  |  | $ | 185,001 |  |  | $ | — |  |  | $ | 209,208 |
(1) Included in cash and cash equivalents on our consolidated balance sheets. (2) Included in restricted cash on our consolidated balance sheets. (3) Included in current portion of marketable securities on our consolidated balance sheets. (4) Included in noncurrent portion of marketable securities on our consolidated balance sheets. Equity Investment In December 2007, we received 13,842,625 ordinary shares in Sienna Cancer Diagnostics Limited, or Sienna, in connection with a license we granted to them for our hTERT technology for use in human diagnostics. The shares, which represented less than 20% ownership, were recorded at a zero cost basis under the cost method of accounting, upon receipt. Since the adoption of ASU 2016-01 on January 1, 2018, we reassessed the fair value of our equity investment in Sienna at each reporting date and any resulting change in fair value was recognized on our consolidated statements of operations. In April 2020, Sienna announced its merger with BARD1 Life Sciences Limited, or BARD1, subject to approval by Sienna’s shareholders. Effective August 3, 2020, the merger was complete, and we received 13 BARD1 shares for every five shares of Sienna ordinary shares, resulting in our ownership of 35,990,825 shares of BARD1. During the first quarter of 2021, we sold all of our holdings in BARD1 and recognized a net gain of approximately $1,233,000 from the sales, including gains from foreign currency translation adjustments, which has been included in other income and expense on our consolidated statements of operations. As of March 31, 2021, no value remained for our equity investment in BARD1. Credit Risk We currently place our cash, restricted cash, cash equivalents and marketable securities with five financial institutions in the United States. Generally, these deposits may be redeemed upon demand and therefore, bear minimal risk. Deposits with banks may exceed the amount of insurance provided on such deposits. Financial instruments that potentially subject us to concentrations of credit risk consist primarily of cash equivalents and marketable securities. Cash equivalents and marketable securities currently consist of money market funds, government-sponsored enterprise securities, U.S. Treasury securities, municipal securities, commercial paper and corporate notes. Our investment policy, approved by the audit committee of our board of directors, limits the amount we may invest in any one type of investment issuer, thereby reducing credit risk concentrations. However, we are exposed to credit risk in the event of default by the financial institutions holding our cash and cash equivalents to the extent recorded in our consolidated balance sheets. We have not experienced any losses in such accounts and we believe that we are not exposed to significant credit risk of our financial position at the depository institutions in which those deposits are held.

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- Definition The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=126976982&loc=d3e19207-110258 + Details
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