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INCOME TAXES - DEFERRED TAXES (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Significant components of deferred tax assets
Net operating loss carryforwards	$ 254,500,000	$ 241,300,000
Federal and state tax credits	56,700,000	49,600,000
Capitalized research and development	21,800,000	6,900,000
Stock-based compensation	10,800,000	10,200,000
Operating lease liabilities	1,300,000	1,400,000
Other	5,600,000	2,600,000
Total deferred tax assets	350,700,000	312,000,000
Less: valuation allowance	(349,600,000)	(310,700,000)
Net deferred tax assets	1,100,000	1,300,000
Operating leases, right-of-use assets	(1,100,000)	(1,300,000)
Total deferred tax liabilities	(1,100,000)	(1,300,000)
Valuation allowance
Increase (decrease) in valuation allowance	$ 38,900,000	$ 33,500,000

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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-Section 50
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