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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Gain (Loss)
Balances at Dec. 31, 2021 $ 126,416 $ 324 $ 1,398,006 $ (1,271,741) $ (173)
Balances (in shares) at Dec. 31, 2021   323,731,591      
Increase (Decrease) in Stockholders' Equity          
Net loss (30,098)     (30,098)  
Other comprehensive income (loss) (539)       (539)
Foreign currency translation adjustment 1       1
Stock-based compensation related to issuance of common stock and options in exchange for services 15   15    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   5,284      
Stock-based compensation for equity-based awards to employees and directors 1,692   1,692    
Balances at Mar. 31, 2022 97,487 $ 324 1,399,713 (1,301,839) (711)
Balances (in shares) at Mar. 31, 2022   323,736,875      
Balances at Dec. 31, 2022 79,998 $ 390 1,493,469 (1,413,642) (219)
Balances (in shares) at Dec. 31, 2022   390,262,524      
Increase (Decrease) in Stockholders' Equity          
Net loss (38,122)     (38,122)  
Other comprehensive income (loss) 75       75
Foreign currency translation adjustment (16)       (16)
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs of $14,507 213,337 $ 68 213,269    
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs of $14,507 (in shares)   68,007,741      
Issuance of common stock in connection with exercise of warrants 59,835 $ 45 59,790    
Issuance of common stock in connection exercise of warrants (in shares)   44,983,193      
Stock-based compensation related to issuance of common stock and options in exchange for services 112 $ 1 111    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   9,360      
Issuance of common stock under equity plans 7,875 $ 5 7,870    
Issuance of common stock under equity plans (in shares)   5,469,028      
Stock-based compensation for equity-based awards to employees and directors 2,961   2,961    
Balances at Mar. 31, 2023 $ 326,055 $ 509 $ 1,777,470 $ (1,451,764) $ (160)
Balances (in shares) at Mar. 31, 2023   508,731,846