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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2023 | Sep. 30, 2022
Cash flows from operating activities: |  |
Net loss | $ (132,154) | $ (99,266)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 328 | 208
Accretion and amortization on investments, net | (8,335) | (9)
Amortization of debt issuance costs/debt discounts | 742 | 1,103
Stock-based compensation for services by non-employees | 650 | 140
Stock-based compensation for employees and directors | 14,110 | 5,813
Amortization of right-of-use assets | 464 | 431
Changes in assets and liabilities: |  |
Current and noncurrent assets | (13,694) | (24,506)
Current and noncurrent liabilities | 11,084 | 23,888
Net cash used in operating activities | (126,805) | (92,198)
Cash flows from investing activities: |  |
Purchases of property and equipment | (766) | (291)
Purchases of marketable securities | (459,727) | (97,336)
Proceeds from maturities of marketable securities | 232,602 | 140,706
Net cash (used in) provided by investing activities | (227,891) | 43,079
Cash flows from financing activities: |  |
Proceeds from issuances of common stock from equity plans | 9,492 | 1,962
Proceeds from issuance of common stock from public offering and pre-funded warrant, net of paid issuance costs | 213,337 | 69,916
Proceeds from exercise of warrants | 105,912 | 3,638
Debt discount and issuance costs for debt financing |  | (175)
Net cash provided by financing activities | 328,741 | 75,341
Effect of exchange rates on cash, cash equivalents and restricted cash | (9) | 10
Net increase in cash, cash equivalents and restricted cash | (25,964) | 26,232
Cash, cash equivalents and restricted cash at the beginning of the period | 57,209 | 35,235
Cash, cash equivalents and restricted cash at the end of the period | $ 31,245 | $ 61,467

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