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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Gain (Loss)
--- | --- | --- | --- | --- | ---
Balances at Dec. 31, 2021 | $ 126,416 | $ 324 | $ 1,398,006 | $ (1,271,741) | $ (173)
Balances (in shares) at Dec. 31, 2021 |  | 323,731,591 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (30,098) |  |  | (30,098) |
Other comprehensive income (loss) | (539) |  |  |  | (539)
Foreign currency translation adjustment | 1 |  |  |  | 1
Stock-based compensation related to issuance of common stock and options in exchange for services | 15 |  | 15 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 5,284 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 1,692 |  | 1,692 |  |
Balances at Mar. 31, 2022 | 97,487 | $ 324 | 1,399,713 | (1,301,839) | (711)
Balances (in shares) at Mar. 31, 2022 |  | 323,736,875 |  |  |
Balances at Dec. 31, 2021 | 126,416 | $ 324 | 1,398,006 | (1,271,741) | (173)
Balances (in shares) at Dec. 31, 2021 |  | 323,731,591 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (99,266) |  |  |  |
Foreign currency translation adjustment | 21 |  |  |  |
Balances at Sep. 30, 2022 | 108,172 | $ 382 | 1,479,417 | (1,371,007) | (620)
Balances (in shares) at Sep. 30, 2022 |  | 381,214,326 |  |  |
Balances at Mar. 31, 2022 | 97,487 | $ 324 | 1,399,713 | (1,301,839) | (711)
Balances (in shares) at Mar. 31, 2022 |  | 323,736,875 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (28,117) |  |  | (28,117) |
Other comprehensive income (loss) | (82) |  |  |  | (82)
Foreign currency translation adjustment | 11 |  |  |  | 11
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs | 69,916 | $ 53 | 69,863 |  |
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs (in shares) |  | 53,333,334 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 13 |  | 13 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 4,637 |  |  |
Issuance of common stock under equity plans | 761 | $ 1 | 760 |  |
Issuance of common stock under equity plans (in shares) |  | 589,913 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 2,058 |  | 2,058 |  |
Balances at Jun. 30, 2022 | 142,047 | $ 378 | 1,472,407 | (1,329,956) | (782)
Balances (in shares) at Jun. 30, 2022 |  | 377,664,759 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (41,051) |  |  | (41,051) |
Other comprehensive income (loss) | 162 |  |  |  | 162
Foreign currency translation adjustment | 9 |  |  |  |
Issuance of common stock in connection with exercise of warrants | 3,638 | $ 3 | 3,635 |  |
Issuance of common stock in connection exercise of warrants (in shares) |  | 2,798,003 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 112 |  | 112 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 3,071 |  |  |
Issuance of common stock under equity plans | 1,201 | $ 1 | 1,200 |  |
Issuance of common stock under equity plans (in shares) |  | 748,493 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 2,063 |  | 2,063 |  |
Balances at Sep. 30, 2022 | 108,172 | $ 382 | 1,479,417 | (1,371,007) | (620)
Balances (in shares) at Sep. 30, 2022 |  | 381,214,326 |  |  |
Balances at Dec. 31, 2022 | 79,998 | $ 390 | 1,493,469 | (1,413,642) | (219)
Balances (in shares) at Dec. 31, 2022 |  | 390,262,524 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (38,122) |  |  | (38,122) |
Other comprehensive income (loss) | 75 |  |  |  | 75
Foreign currency translation adjustment | (16) |  |  |  | (16)
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs | 213,337 | $ 68 | 213,269 |  |
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs (in shares) |  | 68,007,741 |  |  |
Issuance of common stock in connection with exercise of warrants | 59,835 | $ 45 | 59,790 |  |
Issuance of common stock in connection exercise of warrants (in shares) |  | 44,983,193 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 112 | $ 1 | 111 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 9,360 |  |  |
Issuance of common stock under equity plans | 7,875 | $ 5 | 7,870 |  |
Issuance of common stock under equity plans (in shares) |  | 5,469,028 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 2,961 |  | 2,961 |  |
Balances at Mar. 31, 2023 | 326,055 | $ 509 | 1,777,470 | (1,451,764) | (160)
Balances (in shares) at Mar. 31, 2023 |  | 508,731,846 |  |  |
Balances at Dec. 31, 2022 | 79,998 | $ 390 | 1,493,469 | (1,413,642) | (219)
Balances (in shares) at Dec. 31, 2022 |  | 390,262,524 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (132,154) |  |  |  |
Foreign currency translation adjustment | (9) |  |  |  |
Balances at Sep. 30, 2023 | 290,614 | $ 542 | 1,836,818 | (1,545,796) | (950)
Balances (in shares) at Sep. 30, 2023 |  | 542,479,666 |  |  |
Balances at Mar. 31, 2023 | 326,055 | $ 509 | 1,777,470 | (1,451,764) | (160)
Balances (in shares) at Mar. 31, 2023 |  | 508,731,846 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (49,227) |  |  | (49,227) |
Other comprehensive income (loss) | (786) |  |  |  | (786)
Foreign currency translation adjustment | 1 |  |  |  | 1
Issuance of common stock in connection with exercise of warrants | 17,767 | $ 13 | 17,754 |  |
Issuance of common stock in connection exercise of warrants (in shares) |  | 12,842,857 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 99 |  | 99 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 6,327 |  |  |
Issuance of common stock under equity plans | 573 |  | 573 |  |
Issuance of common stock under equity plans (in shares) |  | 361,074 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 3,945 |  | 3,945 |  |
Balances at Jun. 30, 2023 | 298,427 | $ 522 | 1,799,841 | (1,500,991) | (945)
Balances (in shares) at Jun. 30, 2023 |  | 521,942,104 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (44,805) |  |  | (44,805) |
Other comprehensive income (loss) | (11) |  |  |  | (11)
Foreign currency translation adjustment | 6 |  |  |  | 6
Issuance of common stock in connection with exercise of warrants | 28,309 | $ 19 | 28,290 |  |
Issuance of common stock in connection exercise of warrants (in shares) |  | 19,523,808 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 440 |  | 440 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 9,581 |  |  |
Issuance of common stock under equity plans | 1,044 | $ 1 | 1,043 |  |
Issuance of common stock under equity plans (in shares) |  | 1,004,173 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 7,204 |  | 7,204 |  |
Balances at Sep. 30, 2023 | $ 290,614 | $ 542 | $ 1,836,818 | $ (1,545,796) | $ (950)
Balances (in shares) at Sep. 30, 2023 |  | 542,479,666 |  |  |

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