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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |  |
Net loss | $ (184,127) | $ (141,901) | $ (116,112)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 442 | 288 | 215
Accretion and amortization on investments, net | (11,150) | (965) | 1,424
Amortization of debt issuance costs/debt discount | 1,088 | 1,327 | 893
Net gain on exchange and sales of equity investment |  |  | (1,233)
Stock-based compensation for services by non-employees | 828 | 264 | 91
Stock-based compensation for employees and directors | 18,526 | 8,001 | 8,080
Amortization of right-of-use assets | 591 | 580 | 568
Changes in assets and liabilities: |  |  |
Interest and other receivables | 1,490 | (1,381) | (1,041)
Prepaid and other current assets | (886) | (2,630) | 1,317
Deposit and other assets | 692 | (594) | (3,807)
Accounts payable | (4,029) | 3,503 | (232)
Accrued compensation and benefits | 2,224 | 3,435 | (119)
Accrued liabilities | 7,208 | 3,266 | 14,909
Operating lease liabilities | (640) | (572) | (509)
Net cash used in operating activities | (167,743) | (127,379) | (95,556)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (830) | (431) | (207)
Purchases of marketable securities | (475,594) | (258,007) | (177,434)
Proceeds from maturities of marketable securities | 296,102 | 320,505 | 247,994
Proceeds from sales of equity investment |  |  | 1,594
Net cash provided by (used in) investing activities | (180,322) | 62,067 | 71,947
Cash flows from financing activities: |  |  |
Proceeds from issuances of common stock from equity plans | 13,072 | 2,185 | 797
Proceeds from issuance of common stock and warrants in public offering, net of paid issuance costs | 213,337 | 69,916 |
Proceeds from issuances of common stock from at market offerings, net of paid issuance costs |  |  | 20,385
Proceeds from exercise of warrants | 105,912 | 15,163 | 2,479
Proceeds from debt financing, net of paid debt issuance costs and debt discounts | 29,700 |  | 24,895
Net cash provided by financing activities | 362,021 | 87,264 | 48,556
Net effect of unrealized gains and exchange rates on cash, cash equivalents and restricted cash | (27) | 22 |
Net increase (decrease) in cash, cash equivalents and restricted cash | 13,929 | 21,974 | 24,947
Cash, cash equivalents and restricted cash at the beginning of the period | 57,209 | 35,235 | 10,288
Cash, cash equivalents and restricted cash at the end of the period | $ 71,138 | $ 57,209 | $ 35,235

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- Definition Amount of increase (decrease) from effect of unrealized losses and exchange rate changes on cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; held in foreign currencies; including, but not limited to, disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References No definition available. + Details
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