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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Gain (Loss)
Balances at Dec. 31, 2022 $ 79,998 $ 390 $ 1,493,469 $ (1,413,642) $ (219)
Balances (in shares) at Dec. 31, 2022   390,262,524      
Increase (Decrease) in Stockholders' Equity          
Net loss (38,122)     (38,122)  
Other comprehensive income (loss) 75       75
Foreign currency translation adjustment (16)       (16)
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs 213,337 $ 68 213,269    
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs (in shares)   68,007,741      
Issuance of common stock in connection with exercise of warrants 59,835 $ 45 59,790    
Issuance of common stock in connection exercise of warrants (in shares)   44,983,193      
Stock-based compensation related to issuance of common stock and options in exchange for services 112 $ 1 111    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   9,360      
Issuance of common stock under equity plans 7,875 $ 5 7,870    
Issuance of common stock under equity plans (in shares)   5,469,028      
Stock-based compensation for equity-based awards to employees and directors 2,961   2,961    
Balances at Mar. 31, 2023 326,055 $ 509 1,777,470 (1,451,764) (160)
Balances (in shares) at Mar. 31, 2023   508,731,846      
Balances at Dec. 31, 2023 247,949 $ 545 1,844,988 (1,597,769) 185
Balances (in shares) at Dec. 31, 2023   544,912,215      
Increase (Decrease) in Stockholders' Equity          
Net loss (55,390)     (55,390)  
Other comprehensive income (loss) (448)       (448)
Foreign currency translation adjustment (10)       (10)
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs 141,000 $ 42 140,958    
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs (in shares)   41,999,998      
Issuance of common stock in connection with exercise of warrants 49   49    
Issuance of common stock in connection exercise of warrants (in shares)   37,640      
Stock-based compensation related to issuance of common stock and options in exchange for services 6,749 $ 4 6,745    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   4,211,493      
Issuance of common stock under equity plans 92   92    
Issuance of common stock under equity plans (in shares)   2,462      
Stock-based compensation for equity-based awards to employees and directors 4,877   4,877    
Balances at Mar. 31, 2024 $ 344,868 $ 591 $ 1,997,709 $ (1,653,159) $ (273)
Balances (in shares) at Mar. 31, 2024   591,163,808