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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Cash flows from operating activities:    
Net loss $ (55,390) $ (38,122)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 111 99
Accretion and amortization on investments, net (2,367) (1,727)
Amortization of debt issuance costs/debt discounts 802 242
Stock-based compensation for services by non-employees 92 112
Stock-based compensation for employees and directors 4,877 2,961
Amortization of right-of-use assets 164 152
Changes in assets and liabilities:    
Current and noncurrent assets (819) 1,915
Current and noncurrent liabilities (9,723) (11,997)
Net cash used in operating activities (62,253) (46,365)
Cash flows from investing activities:    
Purchases of property and equipment (615) (372)
Purchases of marketable securities (65,618) (241,611)
Proceeds from maturities of marketable securities 100,440 63,250
Net cash provided by (used in) investing activities 34,207 (178,733)
Cash flows from financing activities:    
Proceeds from issuances of common stock from equity plans 6,749 7,875
Proceeds from issuance of common stock from public offering and pre-funded warrant, net of paid issuance costs 141,000 213,337
Proceeds from exercise of warrants 49 59,835
Net cash provided by financing activities 147,798 281,047
Effect of exchange rates on cash, cash equivalents and restricted cash (10) (16)
Net increase in cash, cash equivalents and restricted cash 119,742 55,933
Cash, cash equivalents and restricted cash at the beginning of the period 71,138 57,209
Cash, cash equivalents and restricted cash at the end of the period $ 190,880 $ 113,142