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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Gain (Loss)
--- | --- | --- | --- | --- | ---
Balances at Dec. 31, 2021 | $ 126,416 | $ 324 | $ 1,398,006 | $ (1,271,741) | $ (173)
Balances (in shares) at Dec. 31, 2021 |  | 323,731,591 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net Income (Loss) | (141,901) |  |  | (141,901) |
Other comprehensive income (loss) | (68) |  |  |  | (68)
Foreign currency translation adjustment | 22 |  |  |  | 22
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs | 69,916 | $ 53 | 69,863 |  |
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs (in shares) |  | 53,333,334 |  |  |
Issuance of common stock in connection with exercise of warrants | 15,163 | $ 12 | 15,151 |  |
Issuance of common stock in connection with exercise of warrants (in shares) |  | 11,663,387 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 264 |  | 264 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 15,962 |  |  |
Issuances of common stock under equity plans | 2,185 | $ 1 | 2,184 |  |
Issuances of common stock under equity plans (in shares) |  | 1,518,250 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 8,001 |  | 8,001 |  |
Balances at Dec. 31, 2022 | 79,998 | $ 390 | 1,493,469 | (1,413,642) | (219)
Balances (in shares) at Dec. 31, 2022 |  | 390,262,524 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net Income (Loss) | (184,127) |  |  | (184,127) |
Other comprehensive income (loss) | 431 |  |  |  | 431
Foreign currency translation adjustment | (27) |  |  |  | (27)
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs | 213,337 | $ 68 | 213,269 |  |
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs (in shares) |  | 68,007,741 |  |  |
Issuance of common stock in connection with exercise of warrants | 105,912 | $ 78 | 105,834 |  |
Issuance of common stock in connection with exercise of warrants (in shares) |  | 77,349,858 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 829 | $ 1 | 828 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 36,864 |  |  |
Issuances of common stock under equity plans | 13,070 | $ 8 | 13,062 |  |
Issuances of common stock under equity plans (in shares) |  | 9,255,228 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 18,526 |  | 18,526 |  |
Balances at Dec. 31, 2023 | $ 247,949 | $ 545 | 1,844,988 | (1,597,769) | 185
Balances (in shares) at Dec. 31, 2023 | 544,912,215 | 544,912,215 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net Income (Loss) | $ (174,572) |  |  | (174,572) |
Other comprehensive income (loss) | (88) |  |  |  | (88)
Foreign currency translation adjustment | (12) |  |  |  | (12)
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs | 140,729 | $ 42 | 140,687 |  |
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs (in shares) |  | 41,999,998 |  |  |
Issuance of common stock in connection with exercise of warrants | 1,394 | $ 1 | 1,393 |  |
Issuance of common stock in connection with exercise of warrants (in shares) |  | 1,071,981 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 134 |  | 134 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 8,351 |  |  |
Issuances of common stock under equity plans | 32,683 | $ 18 | 32,665 |  |
Issuances of common stock under equity plans (in shares) |  | 18,395,121 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 31,927 |  | 31,927 |  |
Balances at Dec. 31, 2024 | $ 280,320 | $ 606 | $ 2,051,794 | $ (1,772,341) | $ 261
Balances (in shares) at Dec. 31, 2024 | 606,387,666 | 606,387,666 |  |  |

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