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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Gain (Loss)
Balance at beginning of period (in shares) at Dec. 31, 2023   544,912,215      
Balance at beginning of period at Dec. 31, 2023 $ 247,949 $ 545 $ 1,844,988 $ (1,597,769) $ 185
Increase (Decrease) in Stockholders' Equity          
Net loss (55,390)     (55,390)  
Other comprehensive income (loss) (448)       (448)
Foreign currency translation adjustments (10)       (10)
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs of $9,000 (in shares)   41,999,998      
Issuance of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs of $9,000 141,000 $ 42 140,958    
Issuances of common stock in connection with exercise of warrants (in shares)   37,640      
Issuance of common stock in connection with exercise of warrants 49   49    
Issuance of common stock under equity plans (in shares)   2,462      
Issuances of common stock under equity plans 92   92    
Stock-based compensation related to issuances of common stock and options for services (in shares)   4,211,493      
Stock-based compensation related to issuances of common stock and options for services 6,749 $ 4 6,745    
Stock-based compensation for equity-based awards to employees and directors 4,877   4,877    
Balance at end of period (in shares) at Mar. 31, 2024   591,163,808      
Balance at end of period at Mar. 31, 2024 344,868 $ 591 1,997,709 (1,653,159) (273)
Balance at beginning of period (in shares) at Dec. 31, 2024   606,387,666      
Balance at beginning of period at Dec. 31, 2024 280,320 $ 606 2,051,794 (1,772,341) 261
Increase (Decrease) in Stockholders' Equity          
Net loss (19,835)     (19,835)  
Other comprehensive income (loss) 55       55
Foreign currency translation adjustments (12)       (12)
Exercise of Pre-Funded Warrant (in shares)   30,369,830      
Exercise of Pre-Funded Warrant 31 $ 31      
Issuance of common stock under equity plans (in shares)   155,349      
Issuances of common stock under equity plans 256   256    
Stock-based compensation related to issuances of common stock and options for services (in shares)   4,913      
Stock-based compensation related to issuances of common stock and options for services 15   15    
Stock-based compensation for equity-based awards to employees and directors 7,408   7,408    
Balance at end of period (in shares) at Mar. 31, 2025   636,917,758      
Balance at end of period at Mar. 31, 2025 $ 268,238 $ 637 $ 2,059,473 $ (1,792,176) $ 304