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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Cash flows from operating activities:    
Net loss $ (54,638) $ (149,220)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 387 404
Accretion and amortization on investments, net (5,477) (7,281)
Amortization of debt issuance costs/debt discounts 788 1,894
Non-cash interest expense on liabilities for sales of future royalties 15,043 0
Stock-based compensation for services by non-employees 70 122
Stock-based compensation for employees and directors 20,888 24,392
Amortization of right-of-use assets 542 501
Increase in allowance for doubtful accounts (4) 0
Changes in assets and liabilities:    
Inventory (56,708) (20,283)
Accounts receivable, net 589 (28,007)
Prepaid expenses, interest receivable and other assets 167 (1,842)
Current and noncurrent liabilities (114) 4,647
Payment on Royalty agreement (10,503) 0
Net cash used in operating activities (88,970) (174,673)
Cash flows from investing activities:    
Purchases of property and equipment (49) (821)
Purchases of marketable securities (200,202) (292,141)
Proceeds from maturities of marketable securities 286,353 290,469
Net cash provided by (used in) investing activities 86,102 (2,493)
Cash flows from financing activities:    
Proceeds from issuances of common stock from equity plans 1,389 26,696
Proceeds from issuance of common stock from offering and pre-funded warrant, net of paid issuance costs 0 140,729
Proceeds from exercise of warrants 0 418
Proceeds from employee stock purchase plan 500 366
Net cash provided by financing activities 1,889 168,209
Effect of exchange rates on cash, cash equivalents and restricted cash 96 17
Net increase in cash, cash equivalents and restricted cash (883) (8,940)
Cash, cash equivalents and restricted cash at the beginning of the period 80,876 71,138
Cash, cash equivalents and restricted cash at the end of the period $ 79,993 $ 62,198