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Commitments and Contingencies - Additional Information (Details) $ in Thousands, SFr in Millions | 1 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | ---
Aug. 31, 2020 | Sep. 30, 2021 USD ($) | Sep. 30, 2021 CHF (SFr) | Apr. 30, 2021 CHF (SFr) | Dec. 31, 2020 USD ($)
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Operating lease right-of-use asset |  | $ 68,450 |  |  | $ 73,672
Lease Agreement |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Operating lease right-of-use asset |  | 0 |  |  |
Lease liabilities |  | 0 |  |  |
Clinical and Commercial Supply of Drug Substance | Manufacturing Agreement | Lonza |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Annual suite fees payment | SFr |  |  |  | SFr 150.0 |
Revised estimated capital contribution | SFr |  |  |  | SFr 75.0 |
Manufacturing agreement initial term | 8 years |  |  |  |
Clinical and Commercial Supply of Drug Substance | Maximum | Manufacturing Agreement | Lonza |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Manufacturing agreement term that can be extended | 16 years |  |  |  |
Other Assets [Member] | Manufacturing Agreement |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Manufacturing Agreement Expense |  | $ 38,700 | SFr 35.0 |  |

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- Definition Present value of lessee's discounted obligation for lease payments from operating lease. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 45 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=121603541&loc=SL77918627-209977 + Details
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