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Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2021

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Summary of Stock Options Activity under 2018 Plan and 2015 Equity Incentive Plan

Stock option activity under the 2018 Plan and 2015 Equity Incentive Plan (the "2015 Plan") is summarized as follows:

		Number of Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2020			6,897,276			$	24.52				8.07			$	841,704
Granted			1,478,994			$	94.80
Exercised			(348,420	)		$	17.06
Forfeited or canceled			(228,118	)		$	41.86
Outstanding at September 30, 2021			7,799,732			$	37.62				7.74			$	431,288

Summary of Restricted Shares

Restricted share activity, including restricted stock awards, restricted stock units, and performance-based restricted stock units, under the 2018 Plan and 2015 Plan is summarized as follows:

		Number of Restricted Shares				Weighted Average Grant Date Fair Value
Unvested at December 31, 2020			359,945			$	59.54
Granted			170,150			$	90.75
Vested			(83,775	)		$	57.98
Canceled			(34,033	)		$	61.24
Unvested at September 30, 2021			412,287			$	72.59

Summary of Stock-based Compensation for Options and Restricted Shares Classified in Condensed Consolidated Statements of Operations and Comprehensive Loss

Stock-based compensation for options, restricted shares, and ESPP is classified in the condensed consolidated statements of operations and comprehensive loss as follows (in thousands):

		Three Months Ended   September 30,								Nine Months Ended   September 30,
		2021				2020				2021				2020
Research and development		$	6,429			$	4,759			$	17,598			$	11,983
General and administrative			5,948				3,482				15,791				9,230
Total stock-based compensation		$	12,377			$	8,241			$	33,389			$	21,213

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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-Name Accounting Standards Codification
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Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year.

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