Income taxes - Unrecognized Deferred Tax Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	$ 867,600	$ 709,443
Scientific research expenditures
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	143,663	127,482
Scientific research expenditures \| Canada
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	143,663	127,482
Investments
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	36,315	21,463
Share issuance costs
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	14,145	23,588
Losses from operations carried forward
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	394,599	284,468
Losses from operations carried forward \| Canada
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	262,887	165,647
Losses from operations carried forward \| Germany
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	46	501
Losses from operations carried forward \| United States
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	46,784	49,237
Losses from operations carried forward \| Denmark
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	65,786	50,495
Losses from operations carried forward \| Hong Kong
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	116	61
Losses from operations carried forward \| United Kingdom
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	13,085	14,304
Capital losses carried forward
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	10,703	0
Capital losses carried forward \| Canada
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	12,958	0
Investment tax credits
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	46,810	43,451
Investment tax credits \| Canada
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	46,810	40,877
Property, plant and equipment and intangible assets
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deductible temporary differences for which no deferred tax asset is recognised	221,365	208,991
UK research and development tax credits \| United Kingdom
Disclosure of temporary difference, unused tax losses and unused tax credits [line items]
Deferred tax assets	$ 122	$ 115