<SEC-DOCUMENT>0000921895-24-001602.txt : 20240719
<SEC-HEADER>0000921895-24-001602.hdr.sgml : 20240719
<ACCEPTANCE-DATETIME>20240719163023
ACCESSION NUMBER:		0000921895-24-001602
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20240719
DATE AS OF CHANGE:		20240719

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Inventiva S.A.
		CENTRAL INDEX KEY:			0001756594
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			I0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91576
		FILM NUMBER:		241128119

	BUSINESS ADDRESS:	
		STREET 1:		50 RUE DE DIJON
		CITY:			DAIX
		STATE:			I0
		ZIP:			21121
		BUSINESS PHONE:		33380447500

	MAIL ADDRESS:	
		STREET 1:		50 RUE DE DIJON
		CITY:			DAIX
		STATE:			I0
		ZIP:			21121

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND L P
		CENTRAL INDEX KEY:			0000918923
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		ORGANIZATION NAME:           	02 Finance
		IRS NUMBER:				363924731
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>sc13da207422010_07192024.htm
<DESCRIPTION>AMENDMENT NO. 2 TO SCHEDULE 13D
<TEXT>
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<p style="margin: 0"></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><b>UNITED STATES</b></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><b>SECURITIES AND EXCHANGE
COMMISSION</b></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><b>Washington, D.C. 20549</b></p>

<p></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><b>SCHEDULE 13D</b></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(Rule 13d-101)</p>

<p></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">INFORMATION TO BE INCLUDED
IN STATEMENTS FILED PURSUANT</p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">TO &#167;&#160;240.13d-1(a)
AND AMENDMENTS THERETO FILED PURSUANT TO</p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">&#167;&#160;240.13d-2(a)</p>

<p></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(Amendment No. 2)<FONT STYLE="font-size: 8pt"><SUP>1</SUP></FONT></p>

<p></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><font style="font-weight: normal"><u>Inventiva S.A.</u></font></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(Name
of Issuer)</p>

<p></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><font style="font-weight: normal"><u>Ordinary Shares, nominal value &euro;0.01 per share</u></font></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(Title of Class of Securities)</p>

<p></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><u>46124U107</u></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(CUSIP Number)</p>

<p style="text-indent: 0pt; margin-right: 0; margin-left: 0"></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><font style="font-weight: normal"></U></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">JAMES KRATKY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">BVF PARTNERS L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">44 Montgomery St., 40th Floor</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">San Francisco, California 94104</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><U>(415) 525-8830</U></P>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-weight: normal"><U></u></font></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(Name, Address and Telephone Number of Person</p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">Authorized to Receive Notices
and Communications)</p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0"><FONT STYLE="font-weight: normal"><U>July 17, 2024</U></FONT></p>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">(Date of Event Which Requires
Filing of This Statement)</P>

<P STYLE="text-align: center; display: block; margin-top: 0; margin-bottom: 0">&nbsp;</p>

<P STYLE="text-indent: 36pt; margin: 0; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif">If
the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule
13D, and is filing this schedule because of &#167;&#167;&#160;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following
box </FONT><FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">.</FONT></p>

<P STYLE="text-indent: 36pt; margin-right: 0; margin-left: 0; font: 10pt Times New Roman, Times, Serif"><i>Note:</i>&#160;&#160;Schedules
filed in paper format shall include a signed original and five copies of the schedule, including all exhibits.&#160;&#160;<i>See
</i>&#167;&#160;240.13d-7 for other parties to whom copies are to be sent.</P>

<P STYLE="text-align: left; display: block; margin-top: 0; margin-bottom: 0">&nbsp;</p>
<P STYLE="text-align: left; display: block; margin-top: 0; margin-bottom: 0">&nbsp;</p>

<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="margin-top: 0; margin-bottom: 6pt"><FONT STYLE="font-size: 7pt">1</FONT>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;
The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided
in a prior cover page.</p>

<p style="text-indent: 36pt; margin-right: 0; margin-left: 0; font: 10pt Times New Roman, Times, Serif">The information required
on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities
Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject
to all other provisions of the Act (however, <I>see</I> the <I>Notes</I>).</p>


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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<p style="text-align: center; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BIOTECHNOLOGY VALUE FUND, L.P.</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">WC</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">4,630,461*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">4,630,461*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">4,630,461*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">8.8%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">PN</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 451,003 ADSs (as defined below), each of which represents one
(1) Share (as defined below).</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<p style="text-align: center"></p>

<P STYLE="margin-top: 0; margin-bottom: 0"></p>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BVF I GP LLC</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">4,630,461*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">4,630,461*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">4,630,461*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">8.8%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">OO</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 451,003 ADSs, each of which represents one (1) Share.</P>

<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: center; border-bottom: black 1pt solid"><TD STYLE="width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->3<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BIOTECHNOLOGY VALUE FUND II, L.P.</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">WC</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">3,321,861*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">3,321,861*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">3,321,861*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">6.3%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">PN</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 234,997 ADSs, each of which represents one (1) Share.</P>

<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: center; border-bottom: black 1pt solid"><TD STYLE="width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->4<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BVF II GP LLC</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">3,321,861*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">3,321,861*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">3,321,861*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">6.3%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">OO</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 234,997 ADSs, each of which represents one (1) Share.</P>

<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: center; border-bottom: black 1pt solid"><TD STYLE="width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->5<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
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    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BIOTECHNOLOGY VALUE TRADING FUND OS, L.P.</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">WC</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">CAYMAN ISLANDS</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">397,086*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">397,086*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">397,086*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">LESS THAN 1%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">PN</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 40 ADSs, each of which represents one (1) Share.</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BVF PARTNERS OS LTD.</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">CAYMAN ISLANDS</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">397,086*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">397,086*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">397,086*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">LESS THAN 1%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">CO</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 40 ADSs, each of which represents one (1) Share.</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
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    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
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    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
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    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BVF GP HOLDINGS LLC</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">7,952,322*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">7,952,322*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">7,952,322*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">15.2%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">OO</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 686,000 ADSs, each of which represents one (1) Share.</P>

<!-- Field: Page; Sequence: 8 -->
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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
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    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
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    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BVF PARTNERS L.P.</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">16.3%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">PN, IA</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 686,040 ADSs, each of which represents one (1) Share.</P>

<!-- Field: Page; Sequence: 9 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: center; border-bottom: black 1pt solid"><TD STYLE="width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->9<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">BVF INC.</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">DELAWARE</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">16.3%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">CO</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 686,040 ADSs, each of which represents one (1) Share.</P>

<!-- Field: Page; Sequence: 10 -->
    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font-size: 10pt"><TR STYLE="vertical-align: top; text-align: center; border-bottom: black 1pt solid"><TD STYLE="width: 100%"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->10<!-- Field: /Sequence --></TD></TR></TABLE></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: top"></TD>
    <TD STYLE="width: 5%; border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; text-align: center; vertical-align: middle"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%; padding-left: 6pt"></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 5%"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-top: black 2.25pt double; border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">1</TD>
    <TD STYLE="border-top: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">NAME OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">MARK N. LAMPERT</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">2</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">(a) &#9746;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">(b) &#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">3</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SEC USE ONLY</TD>
    <TD STYLE="border-top: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle"></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">4</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">SOURCE OF FUNDS</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">AF</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">5</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid; padding-left: 6pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">6</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CITIZENSHIP OR PLACE OF ORGANIZATION</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">USA</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">NUMBER OF</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">7</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">SHARES</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">BENEFICIALLY</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">OWNED BY</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">8</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED VOTING POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">EACH</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">REPORTING</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">PERSON WITH</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">9</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SOLE DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top"> </TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">0</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: middle">10</TD>
    <TD STYLE="border-right: Black 1pt solid; border-top: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="border-top: Black 1pt solid; padding-left: 6pt">SHARED DISPOSITIVE POWER</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="13" STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="3" STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: middle">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="12" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">11</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">8,545,499*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">12</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 2.25pt double">&nbsp;&nbsp;&nbsp;&nbsp;&#9744;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-left: Black 1pt solid"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="14" STYLE="text-align: left; vertical-align: middle">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">13</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="text-align: left; vertical-align: middle">16.3%*</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">14</TD>
    <TD STYLE="border-top: Black 1pt solid; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-top: Black 1pt solid; border-left: Black 1pt solid; padding-left: 6pt">TYPE OF REPORTING PERSON</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-top: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="16" STYLE="border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="border-left: Black 2.25pt double; border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; border-left: Black 1pt solid; padding-left: 6pt">&nbsp;</TD>
    <TD COLSPAN="15" STYLE="border-bottom: Black 2.25pt double; text-align: left; vertical-align: middle">IN</TD>
    <TD STYLE="border-right: Black 2.25pt double; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* Includes 686,040 ADSs, each of which represents one (1) Share.</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
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<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">The following constitutes
Amendment No. 2 to the Schedule 13D filed by the undersigned (&ldquo;Amendment No. 2&rdquo;). This Amendment No. 2 amends the Schedule
13D as specifically set forth herein.</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 5.</TD><TD STYLE="text-align: justify"><U>Interest in Securities of the Issuer</U>.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 1in; text-align: justify; text-indent: 0in">Items 5(a) and (c) are
hereby amended and restated to read as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
aggregate percentage of Shares reported owned by each person named herein is based on 52,477,188 Shares outstanding, which is the total
number of Shares outstanding as reported in Exhibit 99.1 to the Issuer&rsquo;s Report of Foreign Private Issuer on Form 6-K filed with
the Securities and Exchange Commission on May 30, 2024.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">As of the date hereof, (i)
BVF beneficially owned 4,630,461 Shares, including 451,003 Shares underlying ADSs held by it, representing percentage ownership of approximately
8.8% of the Shares outstanding, (ii) BVF2 beneficially owned 3,321,861 Shares, including 234,997 Shares underlying ADSs held by it, representing
percentage ownership of approximately 6.3% of the Shares outstanding, (iii) Trading Fund OS beneficially owned 397,086 Shares, including
40 Shares underlying ADSs held by it, representing percentage ownership of less than 1% of the Shares outstanding, and (iv) 196,091 Shares
were held in the Partners Managed Account, representing percentage ownership of less than 1% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">BVF GP, as the general partner
of BVF, may be deemed to beneficially own the 4,630,461 Shares beneficially owned by BVF, representing percentage ownership of approximately
8.8% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">BVF2 GP, as the general partner
of BVF2, may be deemed to beneficially own the 3,321,861 Shares beneficially owned by BVF2, representing percentage ownership of approximately
6.3% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Partners OS, as the general
partner of Trading Fund OS, may be deemed to beneficially own the 397,086 Shares beneficially owned by Trading Fund OS, representing percentage
ownership of less than 1% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">BVF GPH, as the sole member
of each of BVF GP and BVF2 GP, may be deemed to beneficially own the 7,952,322 Shares beneficially owned in the aggregate by BVF and BVF2,
representing percentage ownership of approximately 15.2% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Partners, as the investment
manager of BVF, BVF2, Trading Fund OS and the Partners Managed Account and the sole member of Partners OS, may be deemed to beneficially
own the 8,545,499 Shares beneficially owned in the aggregate by BVF, BVF2, Trading Fund OS, and held in the Partners Managed Account,
representing percentage ownership of approximately 16.3% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">BVF Inc., as the general
partner of Partners, may be deemed to beneficially own the 8,545,499 Shares beneficially owned by Partners, representing percentage ownership
of approximately 16.3% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Mr. Lampert, as a director
and officer of BVF Inc. may be deemed to beneficially own the 8,545,499 Shares beneficially owned by BVF Inc., representing percentage
ownership of approximately 16.3% of the Shares outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Except
for the acquisition of Royalty Certificates of the Issuer described in Item 6 below, none of the Reporting Persons have entered into any
transactions in the securities of the Issuer during the past sixty days.</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 6.</TD><TD STYLE="text-align: justify"><U>Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer</U>.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Item 6 is hereby amended
to add the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">On July 17, 2024, the Issuer
entered into subscription agreements (the &ldquo;Royalty Certificate Subscription Agreements&rdquo;) with certain investors, including
certain Reporting Persons, pursuant to which the Issuer agreed to issue and sell, and such investors agreed to purchase and acquire, an
aggregate of 201 royalty certificates (the &ldquo;Royalty Certificates&rdquo;), in a transaction exempt from registration under the Securities
Act of 1933, as amended (the &ldquo;Transaction&rdquo;). In connection with the Transaction, the Reporting Persons purchased Royalty Certificates
as follows: BVF (34 Royalty Certificates), BVF2 (26 Royalty Certificates), Trading Fund OS (3 Royalty Certificates) and the Partners Managed
Account (1 Royalty Certificate), constituting a total of 64 Royalty Certificates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">The subscription price of
the Royalty Certificates is &euro;100,000 per certificate. Settlement and delivery of the Royalty Certificates is expected to occur on
or about July 22, 2024, subject to the satisfaction of customary closing conditions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">The Royalty Certificates
will provide the holders thereof with the right to an annual payment of royalties (&ldquo;Royalties&rdquo;) equal to 3% of the future
net sales, if any, of the Issuer&rsquo;s product candidate lanifibranor beginning on the fiscal year following the start of the sales
of lanifibranor following the granting of the market authorization for lanifibranor in (i) the United States of America, (ii) the countries
of the European Union or (iii) the United Kingdom, whichever occurs first, if at all.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">The Royalty Certificates
will have a term of 14 years following the date of issue. In the event of a Merger (as defined in the Royalty Certificates), and upon
the request of the Issuer, the holders of Royalty Certificates and the Issuer will negotiate the terms upon which the Issuer may purchase
all of the then-outstanding Royalty Certificates; provided that neither the Issuer nor the holders of Royalty Certificates will have any
obligation other than to conduct such negotiations in good faith. The Issuer may at any time repurchase in full the Royalty Certificates
by paying a price to be agreed between the Issuer and the holders of the Royalty Certificates. The Issuer may also redeem the Royalty
Certificates from each holder, subject to offering such redemption to every holder. The Issuer also has a pre-emptive right in the event
of the sale of Royalty Certificates by a holder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">In connection with the entry
into the Royalty Certificate Subscription Agreements, the investors party thereto have agreed not to sell, transfer or otherwise dispose
of the Royalty Certificates for a period of six months following the date of closing, subject to certain specified exceptions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">The Royalty Certificates
do not confer any additional financial rights besides the right to payment of Royalties referred to above. Specifically, the Royalty Certificates
do not grant any financial rights on any other products that may be developed by the Issuer beyond lanifibranor.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">In addition, the Royalty
Certificates do not entitle any holder thereof to vote or be deemed the holder of any other securities of the Issuer, nor do they confer
upon any holder the rights of a stockholder of the Issuer or the right to vote for the election of directors or upon any matter submitted
to stockholders at any meeting thereof, or give or withhold consent to any corporate action or other actions affecting stockholders or
to receive dividends or subscription rights or otherwise.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">The foregoing description
of the Royalty Certificate Subscription Agreements and the terms and conditions of the Royalty Certificates are qualified in their entirety
by reference to the form of Royalty Certificate Subscription Agreement, a copy of which is referenced as Exhibit 99.1 hereto and is incorporated
by reference herein.</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 7.</TD><TD STYLE="text-align: justify"><U>Material to be Filed as Exhibits</U>.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 1.5in; text-align: justify; text-indent: -0.5in">Item 7 is hereby
amended to add the following exhibit:</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 12pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.5in">99.1</TD><TD STYLE="text-align: justify">Form of Royalty Certificate Subscription Agreement, dated as of July 17, 2024 (incorporated by reference
to Exhibit 99.1 of the Issuer&rsquo;s Form 6-K, filed with the SEC on July 18, 2024).</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">CUSIP No. 46124U107</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><U>SIGNATURES</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">After reasonable inquiry
and to the best of his or its knowledge and belief, each of the undersigned certifies that the information set forth in this statement
is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">Dated:&#9;July 19, 2024</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BIOTECHNOLOGY VALUE FUND, L.P.</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" ROWSPAN="2" STYLE="layout-grid-mode: line">BIOTECHNOLOGY VALUE TRADING FUND OS LP</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; layout-grid-mode: line">By:</TD>
    <TD STYLE="width: 43%; layout-grid-mode: line">BVF I GP LLC., its general partner</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 3%; layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="width: 46%; layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="layout-grid-mode: line">BVF Partners L.P., its investment manager</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; border-bottom: Black 0.5pt solid">/s/ Mark N. Lampert</P></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="layout-grid-mode: line">BVF Inc., its general partner</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Chief Executive Officer</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">President</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BVF I GP LLC</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BVF GP HOLDINGS LLC</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Chief Executive Officer</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Chief Executive Officer</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BIOTECHNOLOGY VALUE FUND II, L.P.</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="layout-grid-mode: line">BVF II GP LLC, its general partner</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BVF PARTNERS L.P.</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; border-bottom: Black 0.5pt solid">/s/ Mark N. Lampert</P></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="layout-grid-mode: line">BVF Inc., its general partner</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Chief Executive Officer</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">President</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BVF II GP LLC</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BVF INC.</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Chief Executive Officer</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">President</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">BVF PARTNERS OS LTD.</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="layout-grid-mode: line">BVF Partners L.P., its sole member</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; layout-grid-mode: line">/s/ Mark N. Lampert</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD STYLE="layout-grid-mode: line">BVF Inc., its general partner</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">MARK N. LAMPERT</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="layout-grid-mode: line">By:</TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; border-bottom: Black 0.5pt solid">/s/ Mark N. Lampert</P></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">Mark N. Lampert</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="layout-grid-mode: line">President</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="layout-grid-mode: line">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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