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Document and Entity Information - USD ($)
 12 Months Ended
Dec. 31, 2024
Mar. 17, 2025
Jun. 28, 2024
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2024    
Document Fiscal Year Focus 2024    
Document Fiscal Period Focus FY    
Current Fiscal Year End Date --12-31    
Entity File Number 001-42382    
Entity Registrant Name Septerna, Inc.    
Entity Central Index Key 0001984086    
Entity Tax Identification Number 84-3891440    
Title of 12(b) Security Common Stock, par value $0.001 per share    
Trading Symbol SEPN    
Security Exchange Name NASDAQ    
Entity Incorporation, State or Country Code DE    
Entity Address, Address Line One 250 East Grand Avenue    
Entity Address, City or Town South San Francisco    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 94080    
City Area Code 650    
Local Phone Number 338-3533    
Documents Incorporated by Reference

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the registrant’s definitive proxy statement relating to its 2025 Annual Meeting of Stockholders, to be filed with the Securities and Exchange Commission pursuant to Regulation 14A within 120 days after the end of the registrant’s fiscal year ended December 31, 2024, are incorporated by reference into Part III of this Annual Report on Form 10-K to the extent stated herein.

    
Entity Filer Category Non-accelerated Filer    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Small Business true    
Entity Emerging Growth Company true    
Entity Shell Company false    
Entity Ex Transition Period false    
Entity Public Float     $ 0
Entity Common Stock, Shares Outstanding   44,442,496  
Document Annual Report true    
Document Transition Report false    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
ICFR Auditor Attestation Flag false    
Auditor Firm ID 42    
Auditor Name Ernst & Young LLP    
Auditor Location San Mateo, California    
Document Financial Statement Error Correction [Flag] false    
Auditor Opinion

Opinion on the Financial Statements

We have audited the accompanying balance sheets of Septerna, Inc. (the Company) as of December 31, 2024 and 2023, the related statements of operations and comprehensive (loss) income, convertible preferred stock and stockholders’ equity (deficit), and cash flows for each of the two years in the period ended December 31, 2024, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2024 and 2023, and the results of its operations and its cash flows for each of the two years in the period ended December 31, 2024, in conformity with U.S. generally accepted accounting principles.