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Collaboration and Research Service Agreements - Summary of Revenue Recognized, Unrecognized Transaction Price and Estimated Revenue Expected to be Recognized (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024
Disaggregation of Revenue [Line Items] |  |  |
Revenue recognized |  | $ (45,951) | $ (1,075)
Novo Collaboration Agreement |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total transaction price | [1] | 289,036 |
Revenue recognized | [2] | (45,377) |
Unrecognized transaction price as of September 30, 2025 |  | 243,659 |
Novo Collaboration Agreement | Combined License and Research Services |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total transaction price |  | 247,846 |
Novo Collaboration Agreement | Material Right |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total transaction price |  | $ 41,190 |
[1] | Comprised of the allocation of the $195.0 million one-time, non-refundable upfront payment, of which $153.8 million was allocated to the four R&D programs and manufacturing services and $41.2 million was allocated to the material right and $94.0 million of variable consideration related to estimated research and manufacturing services for the four R&D Programs.
[2] | Recorded within revenue in the statement of operations and comprehensive loss for the year ended December 31, 2025, comprised of $26.8 million recognized of the one-time, non-refundable upfront payment and $18.6 million variable considerations related to estimated research services for the four R&D Programs.

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