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Collaboration and Research Service Agreements - Additional Information (Details) - USD ($) $ in Thousands			12 Months Ended
		Jul. 01, 2025	Dec. 31, 2025	Dec. 31, 2024	Aug. 31, 2025
Disaggregation of Revenue [Line Items]
Service revenue			$ 45,951	$ 1,075
Novo Collaboration Agreement
Disaggregation of Revenue [Line Items]
Service revenue	[1]		45,377
One-time non-refundable upfront payment received		$ 195,000	195,000
Novo Collaboration Agreement | Maximum
Disaggregation of Revenue [Line Items]
Milestone payments receivable from collaboration agreement			498,000
Vertex Research Service Agreement
Disaggregation of Revenue [Line Items]
Service revenue			$ 600	$ 1,100
Vertex Asset Purchase
Disaggregation of Revenue [Line Items]
Milestone payment received					$ 12,500
[1] Recorded within revenue in the statement of operations and comprehensive loss for the year ended December 31, 2025, comprised of $26.8 million recognized of the one-time, non-refundable upfront payment and $18.6 million variable considerations related to estimated research services for the four R&D Programs.

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