    <SEC-DOCUMENT>0001193125-26-197416-index.html : 20260430
    <SEC-HEADER>0001193125-26-197416.hdr.sgml : 20260430
    <ACCEPTANCE-DATETIME>20260430162230
    ACCESSION NUMBER:		0001193125-26-197416
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20260430
    DATE AS OF CHANGE:		20260430

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Septerna, Inc.
    		CENTRAL INDEX KEY:			0001984086
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				843891440
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-42382
    		FILM NUMBER:		26925857

    	BUSINESS ADDRESS:
    		STREET 1:		250 EAST GRAND AVENUE, SUITE 65
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    		BUSINESS PHONE:		650-338-3533

    	MAIL ADDRESS:
    		STREET 1:		250 EAST GRAND AVENUE, SUITE 65
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>septerna_2026_naa_card.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: septerna_2026_naa_card.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>img52463029_0.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: img52463029_0.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>img52463029_1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: img52463029_1.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>