    <SEC-DOCUMENT>0001104659-26-054229-index.html : 20260501
    <SEC-HEADER>0001104659-26-054229.hdr.sgml : 20260501
    <ACCEPTANCE-DATETIME>20260501170021
    ACCESSION NUMBER:		0001104659-26-054229
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260501
    DATE AS OF CHANGE:		20260501
    EFFECTIVENESS DATE:		20260501

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			IOVANCE BIOTHERAPEUTICS, INC.
    		CENTRAL INDEX KEY:			0001425205
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				753254381
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-36860
    		FILM NUMBER:		26933604

    	BUSINESS ADDRESS:
    		STREET 1:		825 INDUSTRIAL ROAD
    		STREET 2:		4TH FLOOR
    		CITY:			SAN CARLOS
    		STATE:			CA
    		ZIP:			94070
    		BUSINESS PHONE:		6502607120

    	MAIL ADDRESS:
    		STREET 1:		825 INDUSTRIAL ROAD
    		STREET 2:		4TH FLOOR
    		CITY:			SAN CARLOS
    		STATE:			CA
    		ZIP:			94070

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Lion Biotechnologies, Inc.
    		DATE OF NAME CHANGE:	20131015

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Genesis Biopharma, Inc
    		DATE OF NAME CHANGE:	20100319

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FREIGHT MANAGEMENT CORP
    		DATE OF NAME CHANGE:	20080128
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>iova-20251231xars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: iova-20251231xars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>