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Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Cash flows from operating activities |  |
Net loss | $ (91,585) | $ (71,395)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 277 | 256
Stock-based compensation | 11,660 | 8,055
Issuance of PIK interest debt | 1,713 |
Accrued interest on revenue interest financing liability | 2,657 |
Amortization of debt discount | 1,049 | 698
Other | 874 | 540
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets (includes the change in related party amounts of $0, and $82, respectively) | 1,402 | 2,203
Accounts payable and accrued expenses (includes the change in related party amounts of $(1,102), and $722, respectively) | 2,865 | (12,860)
Accrued clinical trial expenses | (1,061) | (5,759)
Accrued interest | 88 | (10)
Operating right-of-use asset and lease liabilities | (293) | 50
Other long-term assets | (464) | 93
Net cash used in operating activities | (70,818) | (78,129)
Cash flows from investing activities |  |
Cash paid for property, plant and equipment | (495) | (214)
Net cash used in investing activities | (495) | (214)
Cash flows from financing activities |  |
Proceeds from issuance of common stock from exercise of stock options |  | 516
Net proceeds from revenue interest financing transaction | 95,446 |
Net cash provided by financing activities | 95,446 | 516
Net increase (decrease) in cash and cash equivalents | 24,133 | (77,827)
Cash and cash equivalents – beginning of period | 183,259 | 287,496
Cash and cash equivalents – end of period | 207,392 | 209,669
Supplemental disclosure of cash flow information |  |
Interest paid | 2,919 | 1,833
Supplemental disclosure of noncash investing and financing activities |  |
Property and equipment purchases included in accounts payable and accrued liabilities | 16 | 3
Operating lease liabilities arising from obtaining right-of-use assets | 554 |
Settlement of ESPP liability in common stock | 515 | 358
Settlement of 401(k) liability in common stock | $ 254 | $ 323

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