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Segment Information (Tables) | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Summary of significant segment expenses and segment net loss | The following table summarizes our significant segment expenses and segment net loss for the three and nine months ended September 30, 2025 and 2024 (in thousands):
|  | For the three months ended September 30, |  |  | For the nine months ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Expenses: |  |  |  |  |  |  |  |  |  |  |  |
Canvuparatide direct program expense |  | $ | 10,130 |  |  | $ | 5,957 |  |  | $ | 27,390 |  |  | $ | 14,920 |
MBX 4291 direct program expense |  |  | 2,669 |  |  |  | 5,514 |  |  |  | 10,991 |  |  |  | 7,659 |
Imapextide direct program expense |  |  | 618 |  |  |  | 2,066 |  |  |  | 3,411 |  |  |  | 9,810 |
Preclinical and other research and development direct expense |  |  | 1,466 |  |  |  | 194 |  |  |  | 4,316 |  |  |  | 769 |
Research and development overhead expense |  |  | 4,387 |  |  |  | 3,016 |  |  |  | 13,292 |  |  |  | 9,034 |
Other segment items (1) |  |  | 2,348 |  |  |  | 1,395 |  |  |  | 5,509 |  |  |  | 4,144 |
Net loss |  | $ | 21,618 |  |  | $ | 18,142 |  |  | $ | 64,909 |  |  | $ | 46,336 |
(1) Other segment items are primarily comprised of general and administrative expenses and interest and other income.

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- Definition Tabular disclosure of the reconciliation of profit (loss) from reportable segments to the consolidated income (loss) before income tax expense (benefit) and discontinued operations. Includes, but is not limited to, reconciliation after income tax if income tax is allocated to the reportable segment. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 31 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-31 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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