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CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY - USD ($) | Common Stock [Member] | Additional Paid-in Capital [Member] | Retained Earnings [Member] | Total
--- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2014 | $ 194,888 | $ 78,675,686 | $ (90,116,254) | $ (11,245,680)
Beginning Balance (in shares) at Dec. 31, 2014 | 19,488,814 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |
Stock-based compensation |  | 1,316,509 |  | 1,316,509
Exercise of stock options | $ 1,975 | 510,826 |  | 512,801
Exercise of stock options (in shares) | 197,466 |  |  |
Issuance of common shares | $ 102,983 | 30,865,403 |  | 30,968,386
Issuance of common shares (in shares) | 10,298,311 |  |  |
Net loss |  |  | (13,356,425) | (13,356,425)
Ending Balance at Dec. 31, 2015 | $ 299,846 | 111,368,424 | (103,472,679) | 8,195,591
Ending Balance (in shares) at Dec. 31, 2015 | 29,984,591 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |
Stock-based compensation |  | 1,390,277 |  | 1,390,277
Exercise of stock options | $ 3,409 | 1,074,924 |  | 1,078,333
Exercise of stock options (in shares) | 340,940 |  |  |
Issuance of common shares | $ 26,833 | 18,641,259 |  | 18,668,092
Issuance of common shares (in shares) | 2,683,334 |  |  |
Net loss |  |  | (14,411,144) | (14,411,144)
Ending Balance at Dec. 31, 2016 | $ 330,088 | 132,474,884 | (117,883,823) | $ 14,921,149
Ending Balance (in shares) at Dec. 31, 2016 | 33,008,865 |  |  | 33,008,865
Increase (Decrease) in Stockholders' Equity |  |  |  |
Stock-based compensation |  | 3,608,918 |  | $ 3,608,918
Exercise of stock options | $ 5,365 | 1,429,160 |  | 1,434,525
Exercise of stock options (in shares) | 536,464 |  |  |
Issuance of common shares | $ 8,050 | 15,654,855 |  | 15,662,905
Issuance of common shares (in shares) | 805,000 |  |  |
Net loss |  |  | (10,445,462) | (10,445,462)
Ending Balance at Dec. 31, 2017 | $ 343,503 | $ 153,167,817 | $ (128,329,285) | $ 25,182,035
Ending Balance (in shares) at Dec. 31, 2017 | 34,350,329 |  |  | 34,350,329

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