<SEC-DOCUMENT>0001140361-22-006801.txt : 20220225
<SEC-HEADER>0001140361-22-006801.hdr.sgml : 20220225
<ACCEPTANCE-DATETIME>20220225160137
ACCESSION NUMBER:		0001140361-22-006801
CONFORMED SUBMISSION TYPE:	POSASR
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20220225
DATE AS OF CHANGE:		20220225
EFFECTIVENESS DATE:		20220225

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Axogen, Inc.
		CENTRAL INDEX KEY:			0000805928
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		IRS NUMBER:				411301878
		STATE OF INCORPORATION:			MN
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		POSASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-255807
		FILM NUMBER:		22679738

	BUSINESS ADDRESS:	
		STREET 1:		13631 PROGRESS BLVD.
		STREET 2:		SUITE 400
		CITY:			ALACHUA
		STATE:			FL
		ZIP:			32615
		BUSINESS PHONE:		(386) 462-6817

	MAIL ADDRESS:	
		STREET 1:		13631 PROGRESS BLVD.
		STREET 2:		SUITE 400
		CITY:			ALACHUA
		STATE:			FL
		ZIP:			32615

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AxoGen, Inc.
		DATE OF NAME CHANGE:	20111004

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LECTEC CORP /MN/
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>POSASR
<SEQUENCE>1
<FILENAME>brhc10034416_posasr.htm
<DESCRIPTION>POSASR
<TEXT>
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    <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on February 25, 2022</div>
    <div style="text-align: right;">Registration Statement No. 333-255807</div>
    <div>&#160; <br>
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">WASHINGTON, D.C. 20549</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 25%; color: #000000;"></div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">POST-EFFECTIVE AMENDMENT NO. 1</div>
    <div style="text-align: center; font-size: 18pt; font-weight: bold;">FORM S-3</div>
    <div style="text-align: center; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; font-size: 24pt; font-weight: bold;">AXOGEN, INC.</div>
    <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;">
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        </font></div>
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        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Minnesota</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">41-1301878</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 49%; vertical-align: top;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">13631 Progress Boulevard, Suite 400</div>
    <div style="text-align: center; font-weight: bold;">Alachua, Florida 32615</div>
    <div style="text-align: center; font-weight: bold;">Tel: (386) 462-6800</div>
    <div style="text-align: center; font-weight: bold;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; font-weight: bold;">Brad Ottinger</div>
    <div style="text-align: center; font-weight: bold;">General Counsel and Chief Compliance Officer</div>
    <div style="text-align: center; font-weight: bold;">Axogen, Inc.</div>
    <div style="text-align: center; font-weight: bold;">13631 Progress Boulevard, Suite 400</div>
    <div style="text-align: center; font-weight: bold;">Alachua, Florida 32615</div>
    <div style="text-align: center; font-weight: bold;">Tel: (386) 462-6800</div>
    <div style="text-align: center; font-weight: bold;">(Name, address, including zip code, and telephone number including area code, of agent for service)</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
    <div style="text-align: center; font-weight: bold;">Fahd M.T. Riaz, Esq.</div>
    <div style="text-align: center;">DLA Piper LLP (US)</div>
    <div style="text-align: center;">1650 Market Street, Suite 5000</div>
    <div style="text-align: center;">Philadelphia, Pennsylvania 19103</div>
    <div style="text-align: center;">Tel: (215) 656-3316</div>
    <div style="text-align: center; font-weight: bold;">Approximate date of commencement of proposed sale to the public:</div>
    <div style="text-align: center; font-weight: bold;">As soon as practicable after this registration statement becomes effective.</div>
    <div>If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box.&#160; &#9744;</div>
    <div>If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest
      reinvestment plans, check the following box.&#160; &#9746;</div>
    <div>If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective
      registration statement for the same offering.&#160; &#9744;</div>
    <div>If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same
      offering.&#160; &#9744;</div>
    <div>If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following
      box.&#160; &#9746;</div>
    <div>If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check
      the following box.&#160; &#9744;</div>
    <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
      filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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        <tr>
          <td style="width: 22.3%; vertical-align: top;">
            <div>Large accelerated filer</div>
          </td>
          <td style="width: 43.38%; vertical-align: top;">&#9744;</td>
          <td style="width: 26.7%; vertical-align: top;">
            <div>Accelerated filer</div>
          </td>
          <td style="width: 7.62%; vertical-align: top;">&#9746;</td>
        </tr>
        <tr>
          <td style="width: 22.3%; vertical-align: top;">
            <div>Non-accelerated filer</div>
          </td>
          <td style="width: 43.38%; vertical-align: top;">&#9744;</td>
          <td style="width: 26.7%; vertical-align: top;">
            <div>Smaller reporting company</div>
          </td>
          <td style="width: 7.62%; vertical-align: top;">
            <div>&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 22.3%; vertical-align: top;">&#160;</td>
          <td style="width: 43.38%; vertical-align: top;">&#160;</td>
          <td style="width: 26.7%; vertical-align: top;">
            <div>Emerging growth company</div>
          </td>
          <td style="width: 7.62%; vertical-align: top;">&#9744;</td>
        </tr>

    </table>
    <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
      Securities Act.&#160; &#9744;</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
    <table cellspacing="0" cellpadding="0" border="0" id="z2dc0afb316204d3ea685185934647a3c" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td nowrap="nowrap" style="width: 40%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Title of each class of</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">securities to be registered</div>
          </td>
          <td nowrap="nowrap" style="width: 15.49%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount to be</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">registered</div>
          </td>
          <td nowrap="nowrap" style="width: 15%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">maximum</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">offering price per</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">unit</div>
          </td>
          <td nowrap="nowrap" style="width: 15%; vertical-align: bottom; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Proposed</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">maximum</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">aggregate offering</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">price</div>
          </td>
          <td nowrap="nowrap" style="width: 15%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Amount of</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">registration</div>
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">fee(3)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 40%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: rgb(0, 0, 0);">Common stock, $0.01 par value per share</div>
          </td>
          <td style="width: 15.49%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">&#160;(1)</div>
          </td>
          <td style="width: 15%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(2)</div>
          </td>
          <td style="width: 15%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">(2)</div>
          </td>
          <td style="width: 15%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; color: rgb(0, 0, 0);">$9,270.00</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
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        <tr>
          <td style="width: 27pt; vertical-align: top;">(1)</td>
          <td style="width: auto; vertical-align: top;">
            <div>An unspecified number of securities is being registered as may from time to time be offered at unspecified prices.</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z3347c8cd4e684170a996be5a5d40d8a1" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 27pt; vertical-align: top;">(2)</td>
          <td style="width: auto; vertical-align: top;">
            <div>Estimated solely for the purpose of calculating the registration fee. The aggregate maximum offering price of all securities issued pursuant to this registration statement will not exceed $100,000,000.</div>
          </td>
        </tr>

    </table>
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        <tr>
          <td style="width: 27pt; vertical-align: top;">(3)</td>
          <td style="width: auto; vertical-align: top;">
            <div>Calculated pursuant to Rule 457(o) under the Securities Act.</div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div>
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
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    </div>
    <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
    <div>&#160;</div>
    <div>This Post-Effective Amendment No. 1 to the Registration Statement on Form S-3 (File No. 333-255807) (&#8220;Post-Effective Amendment No. 1&#8221;) of Axogen, Inc. (the &#8220;Company&#8221;) is being filed because the Company expects that it will no longer be a
      &#8220;well-known seasoned issuer&#8221; (as such term is defined in Rule 405 of the Securities Act of 1933, as amended) when it files its Annual Report on Form 10-K for the fiscal year ended December 31, 2021. Accordingly, the Company is filing this
      Post-Effective Amendment No. 1 for the purpose of including disclosure required for a registrant other than a well-known seasoned issuer, identifying the securities being registered, registering a specific amount of securities and paying the
      associated filing fee.</div>
    <div>&#160;</div>
    <div>This Post-Effective Amendment No. 1 contains a base prospectus which covers the offering, issuance and sale by us of up to $100,000,000 in the aggregate of the securities identified above from time to time in one or more offerings. The base
      prospectus immediately follows this explanatory note. The specific terms of any securities to be offered pursuant to the base prospectus will be specified in a prospectus supplement to the base prospectus.</div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="font-weight: bold;">PROSPECTUS</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">$100,000,000</div>
    <div>&#160;</div>
    <div style="text-align: center;"><img src="image01.jpg"></div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">Common Stock</div>
    <div>&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We may from time to time offer to sell up to $100,000,000 in the aggregate of common stock in amounts, at prices and on terms described in one or more supplements to this prospectus. This prospectus
      provides a general description of our common stock. Each time we sell shares of our common stock, we will provide the specific terms of the shares in a supplement to this prospectus. We may also authorize one or more free writing prospectuses to be
      provided to you in connection with such offerings. The prospectus supplement and any related free writing prospectus may add, update or change information contained in this prospectus. You should carefully read this prospectus, the applicable
      prospectus supplement and any related free writing prospectus, as well as the documents incorporated by reference herein and therein, before you invest in any of our common stock.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We may offer and sell our common stock through underwriters, dealers or agents, or directly to purchasers, or through a combination of these methods. See &#8220;Plan of Distribution&#8221; beginning on page 8 of
      this prospectus.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Our common stock is listed on the Nasdaq Capital Market under the symbol &#8220;AXGN.&#8221; The last reported sale price of our common stock on the Nasdaq Capital Market on February 22, 2022 was $7.26 per
      share.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; font-weight: bold;">Investing in our securities involves risk. See &#8220;Risk Factors&#8221; on page 3 of this prospectus. You should carefully read this prospectus, the applicable prospectus supplement and any
      related free writing prospectus, as well as the documents incorporated by reference herein and therein, before you invest in any of our securities.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; font-weight: bold;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or
      complete. Any representation to the contrary is a criminal offense.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">The date of this prospectus is February 25, 2022</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="TABLEOFCONTENTS"><!--Anchor--></a>TABLE OF CONTENTS</div>
    <div style="text-align: right; font-weight: bold;"><u>Page</u></div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z034a1d050d204bccb461bcb25d5c43c3" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#ABOUTTHISPROSPECTUS">ABOUT THIS PROSPECTUS</a> <br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">
            <div style="color: rgb(0, 0, 0);">1</div>
          </td>
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        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#PROSPECTUSSUMMARY">PROSPECTUS SUMMARY</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">
            <div style="color: rgb(0, 0, 0);">2</div>
          </td>
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        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#RISKFACTORS">RISK FACTORS</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">
            <div>3</div>
          </td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#SPECIALNOTEREGARDINGFORWA">SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">4</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#DESCRIPTIONOFTHESECURITIE">DESCRIPTION OF THE SECURITIES WE MAY OFFER</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">5</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#USEOFPROCEEDS">USE OF PROCEEDS</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">7</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#PLANOFDISTRIBUTION">PLAN OF DISTRIBUTION</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">8</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#WHEREYOUCANFINDMOREINFORM">WHERE YOU CAN FIND MORE INFORMATION</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">10</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#INCORPORATIONOFCERTAININF">INCORPORATION OF CERTAIN INFORMATION BY REFERENCE</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">10</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#LEGALMATTERS">LEGAL MATTERS</a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">11</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top;" rowspan="1"><br>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; text-align: right;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 95.28%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="color: rgb(0, 0, 0);"><a href="#EXPERTS">EXPERTS </a><br>
            </div>
          </td>
          <td style="width: 4.72%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: right;">11</td>
        </tr>

    </table>
    <div>&#160;</div>
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              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <!--PROfilePageNumberReset%Num%1%%%-->
    <div style="text-align: center; font-weight: bold;"></div>
    <div style="text-align: center; font-weight: bold;"><font style="font-weight: normal; font-style: italic; font-size: 8pt;"> </font></div>
    <div style="text-align: center; font-weight: bold;"><a name="ABOUTTHISPROSPECTUS"><!--Anchor--></a>ABOUT THIS PROSPECTUS</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This prospectus is part of a registration statement on Form S-3 that we filed with the U.S. Securities and Exchange Commission (the &#8220;SEC&#8221;) using a &#8220;shelf&#8221; registration process as a &#8220;well-known
      seasoned issuer,&#8221; as defined in Rule 405 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;). Under this shelf registration process, we may offer and sell, from time to time, in one or more offerings up to a total dollar amount of
      $100,000,000 of common stock as described in this prospectus.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This prospectus provides you with a general description of the securities we may offer. Each time we sell the securities, we will, to the extent required by law, provide a prospectus supplement that
      will contain specific information about the terms of the offering. We may also authorize one or more free writing prospectuses to be provided to you in connection with the offering. The prospectus supplement and any related free writing prospectus
      may add, update or change information contained in this prospectus. This prospectus does not contain all of the information included in the registration statement. For a more complete understanding of the offering of the securities, you should refer
      to the registration statement, including its exhibits. You should carefully read this prospectus, the applicable prospectus supplement, and any applicable free writing prospectus, as well as the information and documents incorporated herein and
      therein by reference and the additional information under the heading &#8220;Where You Can Find More Information,&#8221; before making an investment decision.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We have not authorized any dealer, salesman or other person to give any information or to make any representation other than those contained in, or incorporated by reference into, this prospectus and
      the applicable prospectus supplement, and any free writing prospectus we have authorized for use in connection with a specific offering. You must not rely upon any other information or representation.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This prospectus and any accompanying supplement to this prospectus do not constitute an offer to sell or the solicitation of an offer to buy any securities other than the registered securities to
      which they relate, nor do this prospectus and any accompanying supplement to this prospectus constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction to any person to whom it is unlawful to make such offer or
      solicitation in such jurisdiction. You should not assume that the information contained in this prospectus, any accompanying prospectus supplement and any applicable free writing prospectus is accurate on any date subsequent to the date set forth on
      the front of the document or that any information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by reference, even though this prospectus, any accompanying prospectus supplement or any
      applicable free writing prospectus is delivered, or securities sold, on a later date.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This prospectus may not be used by us to consummate sales of our securities unless it is accompanied by a prospectus supplement. To the extent there are inconsistencies between any prospectus
      supplement, this prospectus and any documents incorporated by reference, the document with the most recent date will control.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Unless the context otherwise requires, references in this prospectus to &#8220;we,&#8221; &#8220;us,&#8221; &#8220;our,&#8221; or the &#8220;Company&#8221; refer to Axogen, Inc. and its wholly owned subsidiaries, Axogen Corporation, Axogen
      Processing Corporation, and Axogen Europe GmbH.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This prospectus includes trademarks, tradenames and service marks that are the property of us and of other organizations. Solely for convenience, trademarks, trade names and service marks referred to
      in this prospectus may appear without the &#8220;&#8482;,&#8221; &#8220;&#174;,&#8221; &#8220;&#169;&#8221; or &#8220;SM&#8221; symbols, but such references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights or the rights of the applicable
      licensor to these trademarks, trade names and service marks. We do not intend our use or display of other parties&#8217; trademarks, trade names or service marks to imply, and such use or display should not be construed to imply, a relationship with, or
      endorsement or sponsorship of us by, these other parties.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">1</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
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        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="PROSPECTUSSUMMARY"><!--Anchor--></a>PROSPECTUS SUMMARY</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; font-style: italic;">This summary highlights selected information contained elsewhere in this prospectus or incorporated by reference into this prospectus. This summary does not contain all the
      information that you should consider before investing in our securities. You should carefully read this entire prospectus, the applicable prospectus supplement and any related free writing prospectus, including each of the documents incorporated
      herein or therein by reference, before making an investment decision.</div>
    <div>&#160;</div>
    <div style="text-align: justify; font-weight: bold;">Overview</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 18pt;">Axogen is the leading company focused specifically on the science, development, and commercialization of technologies for peripheral nerve regeneration and repair. We are passionate about providing
      the opportunity to restore nerve function and quality of life for patients with peripheral nerve injuries. We provide innovative, clinically proven, and economically effective repair solutions for surgeons and healthcare providers. Peripheral nerves
      provide the pathways for both motor and sensory signals throughout the body. Every day, people suffer traumatic injuries or undergo surgical procedures that impact the function of their peripheral nerves. Physical damage to a peripheral nerve or the
      inability to properly reconnect peripheral nerves can result in the loss of muscle or organ function, the loss of sensory feeling, or the initiation of pain.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Axogen&#8217;s platform for peripheral nerve repair features a comprehensive portfolio of products,
      including:</div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Avance&#174; Nerve Graft, a biologically active off-the-shelf processed human nerve allograft for bridging
      severed peripheral nerves without the comorbidities associated with a second surgical site;</div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Axoguard Nerve Connector&#174;, a porcine (pig) submucosa extracellular matrix (&#8220;ECM&#8221;) coaptation aid for
      tensionless repair of severed peripheral nerves;</div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Axoguard Nerve Protector&#174;, a porcine submucosa ECM product used to wrap and protect damaged peripheral
      nerves and reinforce the nerve reconstruction while preventing soft tissue attachments;</div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Axoguard Nerve Cap&#174;, a porcine submucosa ECM product used to protect a peripheral nerve end and
      separate the nerve from the surrounding environment to reduce the development of symptomatic or painful neuroma;</div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Avive&#174; Soft Tissue Membrane, a processed human umbilical cord intended for surgical use as a
      resorbable soft tissue conduit; and</div>
    <div style="text-align: justify; text-indent: 36pt;">&#8226;<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> </font>Axotouch&#174; Two-Point Discriminator, used to measure the innervation density of any surface area of the
      skin.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">We suspended the market availability of Avive Soft Tissue Membrane ("Avive") effective June 1, 2021 and we continue discussions with the U.S. Food and Drug Administration to determine the appropriate
      regulatory classification and requirements for Avive. The suspension was not based on any safety or product issues or concerns with Avive. We seek to return Avive to the market, although we are unable to estimate the timeframe or provide any
      assurances that a return to the market will be achievable.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The Axogen portfolio of products is available in the U.S., Canada, Germany, United Kingdom, Spain, South Korea, and several other countries.</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-weight: bold;">Corporate Information</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Axogen, Inc. was incorporated under the laws of the State of Minnesota in 1977. Our principal offices are located at 13631 Progress Boulevard, Suite 400, Alachua, Florida 32615. Our telephone number
      is (386) 462-6800. We have three wholly owned subsidiaries, Axogen Corporation, a Delaware corporation, Axogen Processing Corporation, a Delaware corporation, and Axogen Europe GmbH, a limited liability corporation with its corporate seat in Vienna,
      Austria. Our web address is www.axogeninc.com. Information contained in, or accessible through, our website does not constitute a part of this prospectus or any accompanying prospectus supplement.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Our reports that have been filed with the SEC are available on our website free of charge, including our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K,
      Forms 3, 4 and 5 filed on behalf of directors and executive officers and any amendments to such reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;). Copies of this prospectus and
      the applicable prospectus supplement may also be obtained without charge electronically or by paper by contacting Investor Relations, c/o Axogen, Inc., 13631 Progress Boulevard, Suite 400, Alachua, Florida 32615 or by calling (386) 462-6800.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
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        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="RISKFACTORS"><!--Anchor--></a>RISK FACTORS</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; font-style: italic;">An investment in our common stock involves risks. Prior to making a decision about investing in our common stock, you should carefully consider the specific risks discussed under
      &#8220;Risk Factors&#8221; in our annual report on Form 10-K for our most recent fiscal year, as updated by our quarterly reports on Form 10-Q and other SEC filings subsequent thereto, pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, and in
      any applicable prospectus supplement. The risks and uncertainties described in any applicable prospectus supplement and in our SEC filings are not the only ones we face. Each of these risks could materially and adversely affect our business, results
      of operations, financial condition, and prospects, resulting in a decline in the trading price of our common stock and a complete or partial loss of your investment. The discussion of risks includes or refers to forward-looking statements; you should
      read the explanation of the qualifications and limitation on such forward-looking statements discussed elsewhere in this prospectus.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="SPECIALNOTEREGARDINGFORWA"><!--Anchor--></a>SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">This prospectus, any accompanying prospectus supplement or related free writing prospectus, and the documents incorporated by reference herein and therein may contain &#8220;forward-looking&#8221; statements as
      defined in the Private Securities Litigation Reform Act of 1995. These statements are based on management's current expectations or predictions of future conditions, events, or results based on various assumptions and management's estimates of trends
      and economic factors in the markets in which we are active, as well as our business plans. Words such as &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;intends,&#8221; &#8220;plans,&#8221; &#8220;believes,&#8221; &#8220;seeks,&#8221; &#8220;estimates,&#8221; &#8220;projects,&#8221; &#8220;forecasts,&#8221; &#8220;continue,&#8221; &#8220;may,&#8221; &#8220;should,&#8221; &#8220;will,&#8221;
      &#8220;goals,&#8221; and variations of such words and similar expressions are intended to identify such forward-looking statements. The forward-looking statements may include, without limitation, statements regarding our assessment of our internal controls over
      financial reporting; statements related to the impact of the 2019 novel coronavirus and any and all variants thereof ("COVID-19") on our business; hospital staffing challenges and its impact on our business; statements regarding our growth, our
      financial guidance and performance; product development; product potential; Axogen Processing Center renovation timing and expense; sales growth; product adoption; market awareness of our products; anticipated capital requirements, including the
      potential of future financings; data validation; expected clinical study enrollment, timing and outcomes; our visibility at and sponsorship of conferences and our educational events; regulatory process and approvals; and other factors, including
      legislative, regulatory, political and economic developments not within our control.&#160;The forward-looking statements are and will be subject to risks and uncertainties, which may cause actual results to differ materially from those expressed or
      implied in such forward-looking statements. Forward-looking statements contained in this prospectus, any accompanying prospectus supplement or related free writing prospectus, should be evaluated together with the many uncertainties that affect our
      business and our market, particularly those discussed in the risk factors and cautionary statements set forth in our filings with the SEC, including as described in &#8220;Risk Factors&#8221; included in Item 1A and &#8220;Risk Factor Summary&#8221; of the Annual Report on
      Form 10-K for the most recent fiscal year. Forward-looking statements are not guarantees of future performance, and actual results may differ materially from those projected. The forward-looking statements are representative only as of the date they
      are made and, except as required by applicable law, we assume no responsibility to publicly update or revise any forward-looking statements, whether as a result of new information, future events, changed circumstances or otherwise.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">You should read carefully the risks described in the section entitled &#8220;Risk Factors&#8221; beginning on page 3 of this prospectus, and in any accompanying prospectus supplement or related free writing
      prospectus, together with all information incorporated by reference herein and therein, to better understand the significant risks and uncertainties inherent in our business and underlying any forward-looking statements. As a result of these risks,
      actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements in this prospectus or in any accompanying prospectus supplement or related free writing prospectus, or incorporated by reference
      herein and therein, and you should not place undue reliance on any forward-looking statements.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="DESCRIPTIONOFTHESECURITIE"><!--Anchor--></a>DESCRIPTION OF THE SECURITIES WE MAY OFFER</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from,
      and qualified in its entirety by reference to, our Amended and Restated Articles of Incorporation (&#8220;Articles&#8221;) and our Amended and Restated Bylaws (&#8220;Bylaws&#8221;), in each case as may be amended from time to time, which have been publicly filed with the
      SEC. See &#8220;Where You Can Find More Information&#8221; and &#8220;Incorporation of Certain Information by Reference.&#8221; In addition, please refer to our other publicly filed documents incorporated herein by reference that describe our outstanding registration
      rights, equity incentive plans and other securities.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><!--Anchor-->COMMON STOCK</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Under our Articles, we are authorized to issue up to 100,000,000 shares of common stock, par value $0.01 per share. As of February 22, 2022, 41,795,240&#160; shares of common stock were issued and
      outstanding.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Our common stock is listed on the Nasdaq Capital Market under the symbol "AXGN".</div>
    <div>&#160;</div>
    <div style="text-align: justify; font-weight: bold;">Dividends, Voting Rights and Liquidation</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The holders of shares of our common stock: (i) have equal, ratable rights to dividends from funds legally available therefor, when, as and if declared by the Board of Directors of the Company, (ii)
      are entitled to share ratably in all assets available for distribution to holders of shares of common stock upon liquidation, dissolution or winding up of our affairs, (iii) do not have preemptive, subscription or conversion rights and there are no
      redemption or sinking fund provisions applicable thereto, and (iv) are entitled to one vote per share on all matters that shareholders may vote on at all meetings of shareholders. Except as otherwise required by statute, the Articles or the Bylaws,
      all matters are decided by a majority vote of the number of shares entitled to vote at the time of the vote.</div>
    <div>&#160;</div>
    <div style="text-align: justify; font-weight: bold;">Transfer Agent and Registrar</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Broadridge Corporate Issuer Solutions, Inc. is the transfer agent and registrar for our common stock.</div>
    <div>&#160;</div>
    <div style="text-align: justify; font-weight: bold;">Minnesota Anti-Takeover Laws</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We are governed by the provisions of Sections 302A.671, 302A.673 and 302A.675 of the Minnesota Business Corporation Act (&#8220;MBCA&#8221;). These provisions may discourage a negotiated acquisition or
      unsolicited takeover of us and deprive our shareholders of an opportunity to sell their common stock at a premium over the market price.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">In general, Section 302A.671 of the MBCA provides that a corporation&#8217;s shares acquired in a control share acquisition have no voting rights unless voting rights are approved in a prescribed manner. A
      &#8220;control share acquisition&#8221; is a direct or indirect acquisition of beneficial ownership of shares that would, when added to all other shares beneficially owned by the acquiring person, entitle the acquiring person to have voting power of 20% or more
      in the election of directors.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">In general, Section 302A.673 of the MBCA prohibits a public Minnesota corporation from engaging in a business combination with an interested shareholder for a period of four years after the date of
      the transaction in which the person became an interested shareholder, unless the business combination is approved in a prescribed manner. The term &#8220;business combination&#8221; includes mergers, asset sales and other transactions resulting in a financial
      benefit to the interested shareholder. An &#8220;interested shareholder&#8221; is a person who is the beneficial owner, directly or indirectly, of 10% or more of a corporation&#8217;s voting stock or who is an affiliate or associate of the corporation, and who, at any
      time within four years before the date in question, was the beneficial owner, directly or indirectly, of 10% or more of the corporation&#8217;s voting stock. Section 302A.673 does not apply if a committee of our Board of Directors consisting of all of its
      disinterested directors (excluding current and former officers) approves the proposed transaction or the interested shareholder&#8217;s acquisition of shares before the interested shareholder becomes an interested shareholder.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">If a tender offer is made for our common stock, Section 302A.675 of the MBCA precludes the offeror from acquiring additional shares of stock (including in acquisitions pursuant to mergers,
      consolidations or statutory share exchanges) within two years following the completion of the tender offer, unless shareholders selling their shares in the later acquisition are given the opportunity to sell their shares on terms that are
      substantially the same as those contained in the earlier tender offer. Section 302A.675 does not apply if a committee of our Board of Directors consisting of all of its disinterested directors (excluding its current and former officers) approves the
      proposed acquisition before any shares are acquired pursuant to the earlier tender offer.</div>
    <div>&#160;</div>
    <div style="text-align: justify; font-weight: bold;">Registration Rights</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">In connection with that certain Securities Purchase Agreement, dated as of August 26, 2015, between us and EW Healthcare Partners L.P., formerly named Essex Woodlands Fund IX, L.P. (&#8220;Essex&#8221;), we also
      entered into a Registration Rights Agreement with Essex, pursuant to which we granted Essex certain demand and &#8220;piggy-back&#8221; registration rights with respect to its shares of our common stock. The resale of all of Essex&#8217;s shares has been registered
      pursuant to the Registration Rights Agreement.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="USEOFPROCEEDS"><!--Anchor--></a>USE OF PROCEEDS</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Unless the applicable prospectus supplement states otherwise, we anticipate that the net proceeds from the sale of our securities will be used for general corporate purposes, and we will retain broad
      discretion with respect to the allocation thereof. Additional information on the use of proceeds we receive from the sale of securities covered by this prospectus may be set forth in the prospectus supplement relating to the specific offering.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">7</font></div>
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            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"><a name="PLANOFDISTRIBUTION"><!--Anchor--></a>PLAN OF DISTRIBUTION</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We may offer securities under this prospectus from time to time pursuant to underwritten public offerings, negotiated transactions, block trades or a combination of these methods or through
      underwriters or dealers, through agents and/or directly to one or more purchasers. The securities may be distributed from time to time in one or more transactions:</div>
    <div>&#160;</div>
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        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>at a fixed price or prices, which may be changed;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z2732cae58c0d43b8943fd858dd28817e" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>at market prices prevailing at the time of sale;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z957b275c0b2a4458992acba3ec3250cc" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>at prices related to such prevailing market prices;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="zae3e2ab5c73b48db900831b919864360" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;"><font style="font-family: Times New Roman">&#8226;</font></td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>at negotiated prices; or</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z5033847e4e19403ab6c636f3acb3e565" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;"><font style="font-family: Times New Roman">&#8226;</font></td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>a combination of these pricing methods.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We may also sell equity securities covered by this registration statement in an &#8220;at-the-market offering&#8221; as defined in Rule 415(a)(4) under the Securities Act. Such offering may be made into an
      existing trading market for such securities in transactions at other than a fixed price on or through the facilities of Nasdaq or any other securities exchange or quotation or trading service on which such securities may be listed, quoted or traded
      at the time of sale.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Such at-the-market offerings, if any, may be conducted by underwriters acting as principal or agent.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Each time that securities covered by this prospectus are sold, we will provide a prospectus supplement or supplements that will describe the method of distribution and set forth the terms and
      conditions of the offering of such securities, including the offering price of the securities and the proceeds to us, if applicable.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Offers to purchase the securities being offered by this prospectus may be solicited directly. Agents may also be designated to solicit offers to purchase the securities from time to time. Any agent
      involved in the offer or sale of our securities will be identified in a prospectus supplement.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">If a dealer is utilized in the sale of the securities being offered by this prospectus, the securities will be sold to the dealer, as principal. The dealer may then resell the securities to the
      public at varying prices to be determined by the dealer at the time of resale.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">If an underwriter is utilized in the sale of the securities being offered by this prospectus, an underwriting agreement will be executed with the underwriter at the time of sale and the name of any
      underwriter will be provided in the prospectus supplement that the underwriter will use to make resales of the securities to the public. In connection with the sale of the securities, we, or the purchasers of securities for whom the underwriter may
      act as agent, may compensate the underwriter in the form of underwriting discounts or commissions. The underwriter may sell the securities to or through dealers, and those dealers may receive compensation in the form of discounts, concessions or
      commissions from the underwriters and/or commissions from the purchasers for which they may act as agent. Unless otherwise indicated in a prospectus supplement, an agent will be acting on a best efforts basis and a dealer will purchase securities as
      a principal, and may then resell the securities at varying prices to be determined by the dealer.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Any compensation paid to underwriters, dealers or agents in connection with the offering of the securities, and any discounts, concessions or commissions allowed by underwriters to participating
      dealers will be provided in the applicable prospectus supplement. Underwriters, dealers and agents participating in the distribution of the securities may be deemed to be underwriters within the meaning of the Securities Act, and any discounts and
      commissions received by them and any profit realized by them on resale of the securities may be deemed to be underwriting discounts and commissions. We may enter into agreements to indemnify underwriters, dealers and agents against civil liabilities,
      including liabilities under the Securities Act, or to contribute to payments they may be required to make in respect thereof and to reimburse those persons for certain expenses.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">8</font></div>
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        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">To facilitate the offering of securities, certain persons participating in the offering may engage in transactions that stabilize, maintain or otherwise affect the price of the securities. This may
      include over-allotments or short sales of the securities, which involve the sale by persons participating in the offering of more securities than were sold to them. In these circumstances, these persons would cover such over-allotments or short
      positions by making purchases in the open market or by exercising their over-allotment option, if any. In addition, these persons may stabilize or maintain the price of the securities by bidding for or purchasing securities in the open market or by
      imposing penalty bids, whereby selling concessions allowed to dealers participating in the offering may be reclaimed if securities sold by them are repurchased in connection with stabilization transactions. The effect of these transactions may be to
      stabilize or maintain the market price of the securities at a level above that which might otherwise prevail in the open market. These transactions may be discontinued at any time.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">If indicated in the applicable prospectus supplement, underwriters or other persons acting as agents may be authorized to solicit offers by institutions or other suitable purchasers to purchase the
      securities at the public offering price set forth in the prospectus supplement, pursuant to delayed delivery contracts providing for payment and delivery on the date or dates stated in the prospectus supplement. These purchasers may include, among
      others, commercial and savings banks, insurance companies, pension funds, investment companies and educational and charitable institutions. Delayed delivery contracts will be subject to the condition that the purchase of the securities covered by the
      delayed delivery contracts will not at the time of delivery be prohibited under the laws of any jurisdiction in the United States to which the purchaser is subject. The underwriters and agents will not have any responsibility with respect to the
      validity or performance of these contracts.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We may enter into derivative transactions with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions. If the applicable prospectus
      supplement so indicates, in connection with those derivatives, the third parties may sell securities covered by this prospectus and the applicable prospectus supplement, including in short sale transactions. If so, the third party may use securities
      pledged by us or borrowed from us or others to settle those sales or to close out any related open borrowings of stock, and may use securities received from us in settlement of those derivatives to close out any related open borrowings of stock. The
      third party in such sale transactions will be an underwriter and, if not identified in this prospectus, will be named in the applicable prospectus supplement (or a post-effective amendment). In addition, we may otherwise loan or pledge securities to
      a financial institution or other third party that in turn may sell the securities short using this prospectus and an applicable prospectus supplement. Such financial institution or other third party may transfer its economic short position to
      investors in our securities or in connection with a concurrent offering of other securities.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The specific terms of any lock-up provisions in respect of any given offering will be described in the applicable prospectus supplement.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">In compliance with the guidelines of the Financial Industry Regulatory Authority, Inc. (&#8220;FINRA&#8221;), the maximum consideration or discount to be received by any FINRA member or independent broker dealer
      may not exceed 8% of the aggregate proceeds of the offering.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The underwriters, dealers and agents may engage in transactions with us, or perform services for us, in the ordinary course of business for which they receive compensation.</div>
    <div>&#160;</div>
    <div style="text-align: justify; font-weight: bold;">General Information</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Underwriters, dealers and agents that participate in the distribution of our securities may be underwriters as defined in the Securities Act, and any discounts or commissions they receive and any
      profit they make on the resale of the offered securities may be treated as underwriting discounts and commissions under the Securities Act. Any underwriters or agents will be identified and their compensation described in a prospectus supplement. We
      may indemnify agents, underwriters, and dealers against certain civil liabilities, including liabilities under the Securities Act, or make contributions to payments they may be required to make relating to those liabilities. Our agents, underwriters,
      and dealers, or their affiliates, may be customers of, engage in transactions with, or perform services for us in the ordinary course of business.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Representatives of the underwriters through whom our securities are sold for public offering and sale may engage in over-allotment, stabilizing transactions, syndicate short covering transactions and
      penalty bids in accordance with Regulation M under the Exchange Act. Over-allotment involves syndicate sales in excess of the offering size, which creates a syndicate short position. Stabilizing transactions permit bids to purchase the offered
      securities so long as the stabilizing bids do not exceed a specified maximum.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">9</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Syndicate covering transactions involve purchases of the offered securities in the open market after the distribution has been completed in order to cover syndicate short positions. Penalty bids
      permit the representative of the underwriters to reclaim a selling concession from a syndicate member when the offered securities originally sold by such syndicate member are purchased in a syndicate covering transaction to cover syndicate short
      positions. Such stabilizing transactions, syndicate covering transactions and penalty bids may cause the price of the offered securities to be higher than it would otherwise be in the absence of such transactions. These transactions may be effected
      on a national securities exchange and, if commenced, may be discontinued at any time.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Underwriters, dealers and agents may be customers of, engage in transactions with or perform services for, us and our subsidiaries in the ordinary course of business.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">We will bear all costs, expenses and fees in connection with the registration of the securities as well as the expense of all commissions and discounts, if any, attributable to the sales of any of our
      securities by us.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;"><a name="WHEREYOUCANFINDMOREINFORM"><!--Anchor--></a>WHERE YOU CAN FIND MORE INFORMATION</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We file annual, quarterly and current reports, proxy statements and other information with the SEC. The SEC maintains a website at http://www.sec.gov that contains reports, proxy and information
      statements, and other information regarding issuers that file electronically with the SEC. In addition, we maintain a website at http://www.axogeninc.com and make available free of charge on this website our annual reports on Form 10-K, quarterly
      reports on Form 10-Q, current reports on Form 8-K and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act as soon as reasonably practicable after we electronically file such material with, or furnish
      it to, the SEC. Information contained in, or accessible through, our website does not constitute a part of this prospectus or any accompanying prospectus supplement.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;"><a name="INCORPORATIONOFCERTAININF"><!--Anchor--></a>INCORPORATION OF CERTAIN INFORMATION BY REFERENCE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The SEC allows us to &#8220;incorporate by reference&#8221; much of the information we file with it, which means that we can disclose important information to you by referring you to those publicly available
      documents. All of the information that we incorporate by reference is considered to be part of this prospectus, and any of our subsequent filings with the SEC will automatically update and supersede this information. This prospectus incorporates by
      reference the documents listed below and any future filings made by Axogen with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, except for information furnished under Items 2.02 or 7.01 of our current reports on Form 8-K, or
      exhibits related thereto, between the date of this prospectus and the termination of the offering of the securities:</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z079687726e7e4229850f384478310728" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>our annual report on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000805928/000080592821000044/axgn-20201231.htm">Form 10-K</a> for the fiscal year ended December 31, 2020, filed with the SEC on March 1, 2021;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="zecb25e6c1a52422fbb793f91ec2456ac" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>the information specifically incorporated by reference into our annual report from our definitive proxy statement on <a href="https://www.sec.gov/Archives/edgar/data/805928/000080592821000072/axgn_proxyx2020.htm">Schedule 14A</a>, filed
              with the SEC on March 31, 2021;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z22fb87ade35640ffb88ce1d18affd71f" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>our quarterly reports on Form 10-Q for the quarters ended March 31, 2021, June 30, 2021 and September 30, 2021 filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000080592821000085/axgn-20210331.htm">May
                6, 2021</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000080592821000162/axgn-20210630.htm">August 5, 2021</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000080592821000170/axgn-20210930.htm">November 4, 2021</a>, respectively;</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="zef932a27aa6a41f4b00bd3e3fe72217a" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>our current reports on Form 8-K, filed with the SEC on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000155837021000059/axgn-20210104x8k.htm">January 6, 2021</a>,&#160;<a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000155837021000205/axgn-20210114x8k.htm">January&#160; 14, 2021</a>,&#160;<a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000805928/000080592821000042/axgn-20210222.htm">February
                26, 2021</a>,&#160;<a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000080592821000088/axgn-20210510.htm">May 10, 2021</a>,&#160;<a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000805928/000080592821000128/axgn-20210712.htm">July



                16, 2021</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000805928/000080592821000130/axgn-20210716.htm">July 19, 2021</a>, and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/805928/000080592822000006/axgn-20220131.htm">January 31, 2022</a>; and</div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z83bfb33f619b4d9c8f8a60ecc426dea9" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>the description of our common stock contained in our registration statement on <a href="https://www.sec.gov/Archives/edgar/data/805928/000119312513321130/d579574d8a12b.htm">Form 8-A</a> filed with the SEC on August 6, 2013, including any
              amendment or report filed for the purpose of updating such description.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Any statement contained in any document incorporated by reference herein will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this
      prospectus or any additional prospectus supplements modifies or supersedes such statement. Any statement so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">We will provide, upon written or oral request, at no cost, to each person, including any beneficial owner, to whom a prospectus is delivered, a copy of any or all of the information that has been
      incorporated by reference in the prospectus but not delivered with the prospectus. You may request a copy of these filings by writing us at Investor Relations, c/o Axogen, Inc., 13631 Progress Boulevard, Suite 400, Alachua, Florida 32615. Our
      telephone number is (386) 462-6800.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">10</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">You should rely only on the information incorporated by reference or provided in this prospectus or any supplement. We have not authorized anyone else to provide you with different information. You
      should not assume that information in this prospectus or any supplement is accurate as of any date other than the date on the front of these documents.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;"><a name="LEGALMATTERS"><!--Anchor--></a>LEGAL MATTERS</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">DLA Piper LLP (US) will pass upon certain legal matters relating to the issuance and sale of the securities offered hereby on behalf of Axogen, Inc. Additional legal matters may be passed upon for us
      or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;"><a name="EXPERTS"><!--Anchor--></a>EXPERTS</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The financial statements of Axogen, Inc. incorporated by reference in this Prospectus and the effectiveness of Axogen, Inc.&#8217;s internal control over financial reporting have been audited by Deloitte
      &amp; Touche LLP, an independent registered public accounting firm, as stated in their report. Such financial statements are incorporated by reference in reliance upon the report of such firm given their authority as experts in accounting and
      auditing.</div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">11</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center;"><img src="image01.jpg"></div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">Common Stock</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;"> <font style="font-family: 'Times New Roman';"><br>
      </font></div>
    <div style="text-align: center; font-weight: bold;">Prospectus</div>
    <div>&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">
      <hr noshade="noshade" align="center" style="height: 2px; width: 15%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">February 25, 2022</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <!--PROfilePageNumberReset%Num%1%II-%%-->
    <div style="text-align: center; font-weight: bold;">PART II</div>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">INFORMATION NOT REQUIRED IN PROSPECTUS</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z4604f71f3583444eb37f75ec250115dc" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; font-weight: bold;">Item 14.</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-weight: bold;">Other Expenses of Issuance and Distribution</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The following table sets forth fees and expenses payable by the registrant, other than underwriting discounts and commissions, in connection with the issuance and distribution of the securities being
      registered hereby. All amounts set forth below are estimates. All of such expenses are being borne by the registrant.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" align="center" style="width: 70%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;" id="z002a9c7300984649b1ef32814c12864d" class="cfttable">

        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">SEC Registration Fee</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftcurrcell">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1" class="cftnumcell">
            <div>9,270.00</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px;">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Printing and Engraving Fees</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
            <div>*</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Legal Fees and Expenses</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftcurrcell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1" class="cftnumcell">
            <div>*</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px;">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Accounting Fees and Expenses</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
            <div>*</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Transfer Agent and Registrar Fees</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftcurrcell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1" class="cftnumcell">
            <div>*</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px;">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Miscellaneous</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
            <div>*</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -7.2pt; margin-left: 7.2pt;">Total</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftcurrcell">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1" class="cftnumcell">
            <div>*</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftfncell">&#160;</td>
        </tr>

    </table>
    <div> <br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z84558c8fa022476d9ed03a04cda2c31e" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt; vertical-align: top;">*</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>These fees and expenses depend on the securities offered and the number of issuances, and accordingly cannot be estimated at this time. The foregoing sets forth the general categories of expenses (other than underwriting discounts and
              commissions) that the registrant anticipates it will incur in connection with the offering of securities under this Registration Statement. This expense estimate will appear with respect to each particular offering of securities in the 424(b)
              filing relating to such securities.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z8e32b70f100f47dda3fadc1b1787720c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; font-weight: bold;">Item 15.</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-weight: bold;">Indemnification of Directors and Officers</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Section 302A.521, subd. 2 of the MBCA requires us to indemnify a person made or threatened to be made a party to a proceeding by reason of the former or present official capacity of the person with
      respect to us, against judgments, penalties, fines, settlements, and reasonable expenses, including attorneys&#8217; fees and disbursements, incurred by the person in connection with the proceeding if certain statutory standards are met, unless we amend
      our articles of incorporation or bylaws to prohibit or condition such indemnification rights. Under Section 302A.521, subd. 2, indemnification will be available only where an officer, director or employee can establish that he or she: (i) has not
      been indemnified by another organization with respect to the same acts or omissions; (ii) acted in good faith; (iii) received no improper personal benefits; (iv) in the case of a criminal proceeding, had no reasonable cause to believe the conduct was
      unlawful; and (v) reasonably believed the conduct was in our best interests or, in certain circumstances, reasonably believed that the conduct was not opposed to our best interests. In addition, Section 302A.521, subd. 3 of the MBCA requires payment
      by us, upon written request, of reasonable expenses in advance of final disposition of the proceeding in certain circumstances unless we amend our articles of incorporation or bylaws to prohibit or condition such expense advancement rights. Under
      Section 302A.521, subd. 4, we may amend our articles of incorporation or bylaws to prohibit or condition such indemnification or expense advancement rights. Under Section 302A.521, subd. 6, a decision as to required indemnification shall be made (i)
      by a disinterested majority of our Board of Directors present at a meeting at which a disinterested quorum is present, (ii) by a designated committee of the Board of Directors consisting of two or more disinterested directors, (iii) by special legal
      counsel selected by the board or a committee by vote pursuant to clause (i) or (ii) above, (iv) by an affirmative vote of the our shareholders, in which the shares held by parties to the proceeding are not counted in determining the presence of a
      quorum and are not considered to be present and entitled to vote, or (v) by a court in Minnesota. For purposes of clauses (i) and (ii) above, a director is disinterested if he or she is not a party to the proceeding for which indemnification or
      expense advancement is at issue. Section 302A.521 of the MBCA contains detailed terms regarding such right of indemnification and reference is made thereto for a complete statement of such indemnification rights.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Article 7 of the Articles provides that, to the fullest extent permitted by the MBCA as the same exists or may hereafter be amended, a director of the Company shall not be personally liable to us or
      our shareholders for monetary damages for breach of fiduciary duty as a director; provided, however, that Article 7 shall not eliminate or limit the liability of a director to the extent provided by applicable law (i) for any breach of the director&#8217;s
      duty of loyalty to the corporation or its shareholders, (ii) for acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law, (iii) under Section 302A.559 of the MBCA or 80A.76 of Minnesota Statutes, (iv)
      for any transaction from which the director derived an improper personal benefit, or (v) for any act or omission occurring prior to the effective date of Article 7 or any predecessor of the provision. Neither the amendment, modification or repeal of
      Article 7 nor the adoption of any provision in the Articles of Incorporation inconsistent with Article 7 shall adversely affect any right or protection of a director or officer of the Company with respect to any act or omission that occurred prior to
      the time of such amendment, modification, repeal or adoption. The Bylaws provide that the directors and officers of the Company shall have the right to indemnification provided by Section 302A.521 of the MBCA, as now enacted or hereafter amended.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II-1</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">&#160;We maintain, on behalf of our directors and officers, insurance protection against certain liabilities arising out of the discharge of their duties, as well as insurance covering us for
      indemnification payments made to our directors and officers for certain liabilities. We pay the premiums for such insurance.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Any underwriting agreements that we may enter into will likely provide for our indemnification, our controlling persons, our directors and certain of our officers by the underwriters against certain
      liabilities, including liabilities under the Securities Act.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z834a46caa73e41b2a2cd13e86076330d" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; font-weight: bold;">Item 16.</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-weight: bold;">Exhibits</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">The exhibits to this registration statement are listed in the Exhibit Index to this registration statement, which Exhibit Index is hereby incorporated by reference.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z63cb66f4224543da8d4bc81340cc5b01" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 45pt; vertical-align: top; font-weight: bold;">Item 17.</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-weight: bold;">Undertakings</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(a) The undersigned registrant hereby undertakes:</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(i) to include any prospectus required by Section 10(a)(3) of the Securities Act;</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(ii) to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which,
      individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
      securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission, pursuant to Rule 424(b) if, in the
      aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement; and</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(iii) to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information
      in the registration statement;</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; font-style: italic;">provided</font><font style="font-family: 'Times New Roman';">, <font style="font-style: italic;">however</font>, that paragraphs (a)(1)(i), (ii) and (iii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished
        to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this registration statement, or is contained in a form of prospectus filed pursuant to Rule
        424(b) that is part of the registration statement.</font></div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
      offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(4) That, for the purpose of determining liability under the Securities Act to any purchaser:</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(A) Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part
      of and included in the registration statement; and</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II-2</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">
      <div>(B) Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5) or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii) or (x) for the purpose of
        providing the information required by Section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date
        of the first contract of sale of securities in the offering described in prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective
        date of the registration statement relating to the securities in the registration statement to which the prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided,
        however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part
        of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration
        statement or made in any such document immediately prior to such effective date.</div>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(5) That, for the purpose of determining liability of the registrant under the Securities Act to any purchaser in the initial distribution of the securities, the undersigned registrant undertakes
      that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such
      purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(i) Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on
      behalf of the undersigned registrant; and</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt;">(iv) Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(b) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant&#8217;s annual report pursuant to Section 13(a) or
      Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the
      registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">(c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant, the registrant has been advised that
      in the opinion of the SEC such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of
      expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being
      registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as
      expressed in the Act and will be governed by the final adjudication of such issue.</div>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II-3</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;">EXHIBIT INDEX</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" id="zb2a9e18d8fcd42969c782a4458190ec4" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="color: rgb(0, 0, 0); font-weight: bold;">Exhibit No.</div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 88%; vertical-align: bottom;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;">Description</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; color: rgb(0, 0, 0);">1.1</div>
          </td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; color: rgb(0, 0, 0);">Form of Underwriting Agreement*</div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/805928/000155837018001268/axgn-20171231ex429a90a9a.htm">4.1</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 88%; vertical-align: top;">
            <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/805928/000155837018001268/axgn-20171231ex429a90a9a.htm">Registration Rights Agreement, dated as of August 26, 2015, between the Company and EW Healthcare
                Partners L.P., formerly named Essex Woodlands Fund IX, L.P. (incorporated by reference to Exhibit 4.2 to the annual report on Form 10-K filed on February 28, 2018).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="https://www.sec.gov/Archives/edgar/data/805928/000155837020001238/ex-4d1.htm">4.2</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify;"><a href="https://www.sec.gov/Archives/edgar/data/805928/000155837020001238/ex-4d1.htm">Description of Securities of Axogen, Inc. (incorporated by reference to Exhibit 4.1 to the Company&#8217;s Annual Report on Form
                10-K for the year ended December 31, 2019, filed on February 24, 2020).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex5-1.htm">5.1</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 88%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex5-1.htm">Opinion of DLA Piper LLP (US)&#8224;</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex23-1.htm">23.1</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex23-1.htm">Consent of Deloitte and Touche LLP &#8224;</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex5-1.htm">23.2</a></div>
          </td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 88%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex5-1.htm">Consent of DLA Piper LLP (US)(contained in Exhibit 5.1)&#8224;</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="#SIGNATURES">24.1</a></div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 88%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="margin-right: 2.75pt;"><a href="#SIGNATURES">Power of Attorney (incorporated by reference to the signature page hereto).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="text-align: justify; color: rgb(0, 0, 0);"><a href="brhc10034416_ex107.htm">107</a></div>
          </td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 88%; vertical-align: top;">
            <div style="text-align: justify; margin-right: 2.75pt; color: rgb(0, 0, 0);"><a href="brhc10034416_ex107.htm">Filing Fee Table &#8224;</a></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zdfa949bae5c14420b8abf25450c560a6" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt; vertical-align: top;">&#8224;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>Filed herewith.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z2032693c219b4bb8abc89b44921d33a2" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 18pt; vertical-align: top;">*</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>To be filed by amendment or as an exhibit to a document incorporated by reference or deemed to be incorporated by reference in this registration statement, including a current report on Form 8-K, in connection with the offering of any
              securities, as appropriate.</div>
          </td>
        </tr>

    </table>
    <div>&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 8pt; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II-4</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      <div style="width: 100%;" id="DSPFPageHeader">
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 100.00%;">
                <div style="text-align: left; font-weight: bold;"> <a href="#TABLEOFCONTENTS"><font style="font-weight: normal; font-style: italic; font-size: 8pt;">Table
                      of Contents</font><br>
                  </a></div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;">SIGNATURES<a name="SIGNATURES"><!--Anchor--></a></div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">Each person whose individual signature appears below hereby authorizes and appoints Karen Zaderej, Peter J. Mariani, and Brad Ottinger, and each of them, with full power of substitution and
      resubstitution and full power to act without the other, as his or her true and lawful attorney in fact and agent to act in his or her name, place and stead and to execute in the name and on behalf of each person, individually and in each capacity
      stated below, and to file any and all amendments to this registration statement, including any and all post-effective amendments and amendments thereto, and any registration statement relating to the same offering filed pursuant to Rule 462(b) under
      the Securities Act of 1933, as amended, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto said attorneys in fact and agents, and each of them,
      full power and authority to do and perform each and every act and thing, ratifying and confirming all that said attorneys in fact and agents or any of them or their or his substitute or substitutes may lawfully do or cause to be done by virtue
      thereof.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has
      duly caused this Post-Effective Amendment No. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of Alachua, in the State of Florida on February 25, 2022.</div>
    <div>&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" id="zef476eb562024d2599828771522a5cb9" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="vertical-align: top;" rowspan="1" colspan="3">
            <div style="text-align: justify; font-weight: bold;">Axogen, Inc.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;" rowspan="1">&#160;</td>
          <td style="vertical-align: top;" rowspan="1" colspan="3">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">
            <div style="text-align: justify;">February 25, 2022</div>
          </td>
          <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
            <div style="text-align: justify;">By:</div>
          </td>
          <td style="width: 24%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: justify;">/s/ Karen Zaderej</div>
          </td>
          <td style="width: 21%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="text-align: justify;"><br>
            </div>
          </td>
          <td style="width: 5%; vertical-align: top;" rowspan="1">
            <div style="text-align: justify;">Name:</div>
          </td>
          <td style="vertical-align: top;" colspan="2">
            <div style="text-align: justify;">
              <div>Karen&#160; Zaderej</div>
            </div>
          </td>
        </tr>
        <tr>
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          <td style="width: 2.22%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 2.22%; vertical-align: bottom;">&#160;</td>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
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<DESCRIPTION>EXHIBIT 5.1
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    <div>February 25, 2022</div>
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    <div>Axogen, Inc.</div>
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    <div>Alachua, Florida&#8194;32615</div>
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    <div>Re: <u>Axogen, Inc. &#8211; Post-Effective Amendment No. 1 to the Registration Statement on Form S-3</u></div>
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      <div style="text-align: justify; color: rgb(0, 0, 0);">We have acted as counsel to Axogen,&#160;Inc., a Minnesota corporation (the &#8220;Company&#8221;), in connection with the filing by the Company of a Post-Effective Amendment No. 1 to the Registration Statement
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        registration for issue and sale by the Company of up to $100,000,000 aggregate offering amount of shares of Common Stock, par value $0.01 per share (the &#8220;Common Stock&#8221;), of the Company (the &#8220;Shares&#8221;).</div>
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      <div style="text-align: justify; color: rgb(0, 0, 0);">In connection with this opinion letter, we have examined the Registration Statement and originals, or copies certified or otherwise identified to our satisfaction, of the Articles of
        Incorporation, as amended and restated, of the Company as filed with the Secretary of State of the State of Minnesota, the Bylaws of the Company, as amended and restated, and the minutes of meetings of the shareholders and the Board of Directors of
        the Company as provided to us by the Company and such other documents, records and other instruments as we have deemed appropriate for purposes of the opinion set forth herein.</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">We have assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of the documents submitted to us as originals, the conformity with the originals of
        all documents submitted to us as certified, facsimile or photostatic copies and the authenticity of the originals of all documents submitted to us as copies.</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">&#160;</div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">Based upon the foregoing, we are of the opinion that the Shares have been duly authorized by the Company and when issued and sold by the Company and delivered by the Company against receipt of
        the purchase price therefor, in the manner as the Board of Directors of the Company (or a duly authorized committee thereof) may determine, will be validly issued, fully paid and non-assessable.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">The opinion expressed herein is limited to the Minnesota Business Corporation Act.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">We hereby consent to the use of this opinion as Exhibit&#160;5.1 to the Registration Statement and to the reference to us under the caption &#8220;Legal Matters&#8221; in the prospectus included in the
        Registration Statement.&#160; In giving such consent, we do not hereby admit that we are acting within the category of persons whose consent is required under Section&#160;7 of the Act or the rules&#160;or regulations of the SEC thereunder.</div>
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    <div>&#160;</div>
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          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">Very truly yours,</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 50.00%;">&#160;</td>
            <td rowspan="1" style="width: 50.00%;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 50.00%;">&#160;</td>
            <td rowspan="1" style="width: 50%; font-weight: bold;">/s/ DLA Piper LLP (US)</td>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>brhc10034416_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using EDGARfilings PROfile 8.1.1.0
         Copyright 1995 - 2022 Broadridge -->
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
  <div>
    <div>
      <div style="text-align: right; color: #000000; font-family: 'Times New Roman', Times, serif;">Exhibit 23.1</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-family: 'Times New Roman', Times, serif; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">We consent to the incorporation by reference in this Amendment No. 1 to Registration Statement No. 333-255807 on Form&#160;S-3 of our report dated February 25, 2022 relating to the
        financial statements of Axogen, Inc. and the effectiveness of Axogen, Inc.&#8217;s internal control over financial reporting, appearing in the Annual Report on Form 10-K&#160;of Axogen, Inc. for the year ended December&#160;31, 2021. We also consent to the
        reference to us under the heading &#8220;Experts&#8221; in such Registration Statement.</div>
      <div>&#160;</div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">/s/ DELOITTE&#160;&amp; TOUCHE LLP</div>
    </div>
    <div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">Miami, Florida</div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">February 25, 2022</div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;"> <br>
      </div>
      <div style="color: #000000; font-family: 'Times New Roman', Times, serif;">
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"> </div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>brhc10034416_ex107.htm
<DESCRIPTION>EXHIBIT 107
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using EDGARfilings PROfile 8.1.1.0
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">
  <div id="DSPFPageHeader"></div>
  <div style="text-align: right; font-weight: bold;">Exhibit 107</div>
  <div>&#160;</div>
  <div style="text-align: center; font-weight: bold;">Calculation of Filing Fee Tables</div>
  <div>&#160;</div>
  <div style="text-align: center; font-weight: bold;">Post-Effective Amendment to Form S-3</div>
  <div style="text-align: center;">(Form Type)</div>
  <div>&#160;</div>
  <div style="text-align: center; font-weight: bold;">Axogen, Inc.</div>
  <div style="text-align: center;">(Exact Name of Registrant as Specified in its Charter)</div>
  <div>&#160;</div>
  <div style="text-align: center;"><u>Table 1: Newly Registered Securities</u></div>
  <div>&#160; <br>
  </div>
  <div><br>
  </div>
  <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z86f5f4e34dd14058aa14b6811335392e">

      <tr>
        <td style="width: 11%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
        <td style="width: 10%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Security&#160;Type</div>
        </td>
        <td style="width: 18.7%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Security<br>
            Class<br>
            Title</div>
        </td>
        <td style="width: 9.63%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Fee<br>
            Calculation<br>
            or Carry<br>
            Forward Rule</div>
        </td>
        <td style="width: 9%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Amount<br>
            Registered</div>
        </td>
        <td style="width: 9.35%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Proposed<br>
            Maximum<br>
            Offering Price<br>
            Per Unit</div>
        </td>
        <td style="width: 13.38%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Maximum<br>
            Aggregate<br>
            Offering Price</div>
        </td>
        <td style="width: 8.35%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Fee&#160;Rate</div>
        </td>
        <td style="width: 10.81%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Amount of<br>
            Registration Fee</div>
        </td>
      </tr>
      <tr>
        <td colspan="9" style="vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Newly Registered Securities</div>
        </td>
      </tr>
      <tr>
        <td style="width: 11%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">Fees to Be Paid</div>
        </td>
        <td style="width: 10%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">Equity</div>
        </td>
        <td style="width: 18.7%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">Common Stock, par value $0.01 per share</div>
        </td>
        <td style="width: 9.63%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">457(o)</div>
        </td>
        <td style="width: 9%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">(1)</div>
        </td>
        <td style="width: 9.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">(2)</div>
        </td>
        <td style="width: 13.38%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$100,000,000.00<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
        </td>
        <td style="width: 8.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$0.0000927</div>
        </td>
        <td style="width: 10.81%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$9,270.00</div>
        </td>
      </tr>
      <tr>
        <td style="width: 11%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">Fees Previously Paid</div>
        </td>
        <td style="width: 10%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 18.7%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 9.63%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 9%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 9.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 13.38%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 8.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
        <td style="width: 10.81%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">-</div>
        </td>
      </tr>
      <tr>
        <td style="width: 11%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td colspan="4" style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Total Offering Amounts</div>
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        <td style="width: 9.35%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td style="width: 13.38%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$100,000,000.00</div>
        </td>
        <td style="width: 8.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 10.81%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$9,270.00</div>
        </td>
      </tr>
      <tr>
        <td style="width: 11%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td colspan="4" style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Total Fees Previously Paid</div>
        </td>
        <td style="width: 9.35%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td style="width: 13.38%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 8.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 10.81%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$0.00</div>
        </td>
      </tr>
      <tr>
        <td style="width: 11%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td colspan="4" style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Total Fee Offsets</div>
        </td>
        <td style="width: 9.35%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td style="width: 13.38%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 8.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 10.81%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$0.00</div>
        </td>
      </tr>
      <tr>
        <td style="width: 11%; vertical-align: middle; border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td colspan="4" style="vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center; font-weight: bold;">Net Fee Due</div>
        </td>
        <td style="width: 9.35%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div>&#160;</div>
        </td>
        <td style="width: 13.38%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 8.35%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
        <td style="width: 10.81%; vertical-align: middle; border-right: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="text-align: center;">$9,270.00</div>
        </td>
      </tr>

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  <div> <br>
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        <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
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          <div style="color: rgb(0, 0, 0);">There are being registered hereunder such indeterminate number of shares of common stock as shall have an aggregate initial offering price not to exceed $100,000,000. The proposed maximum initial offering price
            per unit will be determined, from time to time, by the registrant in connection with the issuance by the registrant of the securities registered hereunder.</div>
        </td>
      </tr>

  </table>
  <div> <br>
  </div>
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        <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
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          <div style="color: rgb(0, 0, 0);">The proposed maximum aggregate offering price per class of security will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder
            and is not specified as to each class of security pursuant to General Instruction II.D of Form S-3 under the Securities Act of 1933, as amended.</div>
        </td>
      </tr>

  </table>
  <div> <br>
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        <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
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          <div style="color: rgb(0, 0, 0);">Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(o) under the Securities Act of 1933, as amended. In no event will the aggregate offering price of all securities sold by
            the registrant from time to time pursuant to this registration statement exceed $100,000,000.</div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
