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Warrants (Tables) | 12 Months Ended
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Dec. 31, 2016
Common Stock [Member] |
Class Of Warrant Or Right [Line Items] |
Components of Warrants Outstanding | As of December 31, 2016, outstanding warrants to purchase Common Stock were:
|  | Original Term |  | Exercise Price |  |  | Number of Shares Underlying Warrants |
Original issue date: |  |  |  |  |  |  |  |  |  |
February 2008 |  | 10 years |  | $ | 35.10 |  |  |  | 22,792 |
August 2009 |  | 10 years |  | $ | 21.78 |  |  |  | 33,473 |
July 2010 |  | 9 years |  | $ | 21.78 |  |  |  | 6,694 |
December 2010 |  | 7 years |  | $ | 21.78 |  |  |  | 17,215 |
August 2012 |  | 7 years |  | $ | 21.78 |  |  |  | 167,182 |
January 2015 |  | 5 years |  | $ | 6.96 |  |  |  | 34,483 |
April 2016 (a) |  | 7 years |  | $ | 4.00 |  |  |  | 1,775,580 |
April 2016 (b) |  | 5 years |  | $ | 3.99 |  |  |  | 200,000 |
June 2016 (c) |  | 7 years |  | $ | 4.00 |  |  |  | 1,002,507 |
|  |  |  |  |  |  |  |  | 3,259,926 |
(a) | Issued on April 14, 2016 in connection with the Private Placement to certain accredited investors. The exercise price was reset from $4.98 to $4.00 as a result of the Public Offering that closed on September 26, 2016. In accordance with the anti-dilution provisions, the exercise price of the warrants issued in connection with the Private Placement reset from $4.98 per share to $4.00 per share, which was the price paid by investors in the Public Offering, which closed on September 26, 2016.
(b) | Issued on April 14, 2016 in connection with the Private Placement to placement agents.
(c) | Issued on June 15, 2016 in connection with the Subsequent Financing. The exercise price was reset from $4.98 to $4.00 as a result of the Public Offering that closed on September 26, 2016. In accordance with the anti-dilution provisions, the exercise price of the warrants issued in connection with the Subsequent Financing reset from $4.98 per share to $4.00 per share, which was the price paid by investors in the Public Offering, which closed on September 26, 2016.

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6784392&loc=d3e188667-122775 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=68057994&loc=d3e25284-112666 + Details
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