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Warrants - Outstanding Warrants To Purchase Common Stock Warrants (Detail) - $ / shares | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2016 | Sep. 26, 2016 | Sep. 25, 2016 | Jun. 15, 2016 | Apr. 14, 2016 | Jan. 30, 2015
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Number of Shares Underlying Warrants |  |  |  |  | 1,002,507 |  |
Private Placement [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Exercise Price |  |  | $ 4.00 | $ 4.98 |  |  |
Number of Shares Underlying Warrants |  |  | 1,775,580 |  |  | 1,975,580 |
Private Placement [Member] | Accredited Investors [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Number of Shares Underlying Warrants |  |  |  |  |  | 1,775,580 |
Private Placement [Member] | Placement Agents [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Number of Shares Underlying Warrants |  |  |  |  |  | 200,000 |
Subsequent Financing [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Exercise Price |  |  | $ 4.00 | 4.98 |  |  |
Number of Shares Underlying Warrants |  |  | 1,002,507 |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Exercise Price |  |  |  |  |  |  | $ 6.96
Number of Shares Underlying Warrants |  | 3,259,926 |  |  |  |  |
Common Stock [Member] | Class Of Warrant Or Right Issued on February 2008 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date |  | 2008-02 |  |  |  |  |
Original Term |  | 10 years |  |  |  |  |
Exercise Price |  | $ 35.10 |  |  |  |  |
Number of Shares Underlying Warrants |  | 22,792 |  |  |  |  |
Common Stock [Member] | Class Of Warrant Or Right Issued on August 2009 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date |  | 2009-08 |  |  |  |  |
Original Term |  | 10 years |  |  |  |  |
Exercise Price |  | $ 21.78 |  |  |  |  |
Number of Shares Underlying Warrants |  | 33,473 |  |  |  |  |
Common Stock [Member] | Class Of Warrant Or Right Issued on July 2010 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date |  | 2010-07 |  |  |  |  |
Original Term |  | 9 years |  |  |  |  |
Exercise Price |  | $ 21.78 |  |  |  |  |
Number of Shares Underlying Warrants |  | 6,694 |  |  |  |  |
Common Stock [Member] | Class Of Warrant Or Right Issued on December 2010 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date |  | 2010-12 |  |  |  |  |
Original Term |  | 7 years |  |  |  |  |
Exercise Price |  | $ 21.78 |  |  |  |  |
Number of Shares Underlying Warrants |  | 17,215 |  |  |  |  |
Common Stock [Member] | Class Of Warrant Or Right Issued on August 2012 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date |  | 2012-08 |  |  |  |  |
Original Term |  | 7 years |  |  |  |  |
Exercise Price |  | $ 21.78 |  |  |  |  |
Number of Shares Underlying Warrants |  | 167,182 |  |  |  |  |
Common Stock [Member] | Class Of Warrant Or Right Issued on January 2015 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date |  | 2015-01 |  |  |  |  |
Original Term |  | 5 years |  |  |  |  |
Exercise Price |  | $ 6.96 |  |  |  |  |
Number of Shares Underlying Warrants |  | 34,483 |  |  |  |  |
Common Stock [Member] | Private Placement [Member] | Accredited Investors [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Exercise Price |  |  | $ 4.00 | 4.98 |  |  |
Common Stock [Member] | Private Placement [Member] | Accredited Investors [Member] | Class Of Warrant Or Right Issued on April 2016 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date | [1] | 2016-04 |  |  |  |  |
Original Term | [1] | 7 years |  |  |  |  |
Exercise Price | [1] | $ 4.00 |  |  |  |  |
Number of Shares Underlying Warrants | [1] | 1,775,580 |  |  |  |  |
Common Stock [Member] | Private Placement [Member] | Placement Agents [Member] | Class Of Warrant Or Right Issued on April 2016 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date | [2] | 2016-04 |  |  |  |  |
Original Term | [2] | 5 years |  |  |  |  |
Exercise Price | [2] | $ 3.99 |  |  |  |  |
Number of Shares Underlying Warrants | [2] | 200,000 |  |  |  |  |
Common Stock [Member] | Subsequent Financing [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Exercise Price |  |  | $ 4.00 | $ 4.98 |  |  |
Common Stock [Member] | Subsequent Financing [Member] | Class Of Warrant Or Right Issued on June 2016 [Member] |  |  |  |  |  |  |
Class Of Warrant Or Right [Line Items] |  |  |  |  |  |  |
Issue Date | [3] | 2016-06 |  |  |  |  |
Original Term | [3] | 7 years |  |  |  |  |
Exercise Price | [3] | $ 4.00 |  |  |  |  |
Number of Shares Underlying Warrants | [3] | 1,002,507 |  |  |  |  |
[1] | Issued on April 14, 2016 in connection with the Private Placement to certain accredited investors. The exercise price was reset from $4.98 to $4.00 as a result of the Public Offering that closed on September 26, 2016. In accordance with the anti-dilution provisions, the exercise price of the warrants issued in connection with the Private Placement reset from $4.98 per share to $4.00 per share, which was the price paid by investors in the Public Offering, which closed on September 26, 2016.
[2] | Issued on April 14, 2016 in connection with the Private Placement to placement agents.
[3] | Issued on June 15, 2016 in connection with the Subsequent Financing. The exercise price was reset from $4.98 to $4.00 as a result of the Public Offering that closed on September 26, 2016. In accordance with the anti-dilution provisions, the exercise price of the warrants issued in connection with the Subsequent Financing reset from $4.98 per share to $4.00 per share, which was the price paid by investors in the Public Offering, which closed on September 26, 2016.

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