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Warrants - Outstanding Warrants To Purchase Common Stock Warrants (Detail) - Common Stock [Member] - $ / shares
 3 Months Ended
Mar. 31, 2018
Sep. 26, 2016
Sep. 25, 2016
Class Of Warrant Or Right [Line Items]      
Number of Shares Underlying Warrants 3,633,565    
Class Of Warrant Or Right Issued on August 2009 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date 2009-08    
Classified as Equity    
Original Term 10 years    
Exercise Price $ 21.78    
Number of Shares Underlying Warrants 33,473    
Class Of Warrant Or Right Issued on July 2010 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date 2010-07    
Classified as Equity    
Original Term 9 years    
Exercise Price $ 21.78    
Number of Shares Underlying Warrants 6,694    
Class Of Warrant Or Right Issued on August 2012 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date 2012-08    
Classified as Equity    
Original Term 7 years    
Exercise Price $ 21.78    
Number of Shares Underlying Warrants 167,182    
Class Of Warrant Or Right Issued on January 2015 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date 2015-01    
Classified as Equity    
Original Term 5 years    
Exercise Price $ 6.96    
Number of Shares Underlying Warrants 34,483    
Class Of Warrant Or Right Issued on March 2017 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date [1] 2017-03    
Classified as [1] Equity    
Original Term [1] 5 years    
Exercise Price [1] $ 4.67    
Number of Shares Underlying Warrants [1] 1,338,326    
Private Placement [Member] | Accredited Investors [Member]      
Class Of Warrant Or Right [Line Items]      
Exercise Price   $ 4.00 $ 4.98
Private Placement [Member] | Accredited Investors [Member] | Class Of Warrant Or Right Issued on April 2016 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date [2] 2016-04    
Classified as [2] Liability    
Original Term [2] 7 years    
Exercise Price [2] $ 1.12    
Number of Shares Underlying Warrants [2] 904,800    
Private Placement [Member] | Placement Agents [Member] | Class Of Warrant Or Right Issued on April 2016 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date [3] 2016-04    
Classified as [3] Liability    
Original Term [3] 5 years    
Exercise Price [3] $ 1.12    
Number of Shares Underlying Warrants [3] 146,100    
Subsequent Financing [Member] | Class Of Warrant Or Right Issued on June 2016 [Member]      
Class Of Warrant Or Right [Line Items]      
Issue Date [4] 2016-06    
Classified as [4] Liability    
Original Term [4] 7 years    
Exercise Price [4] $ 4.00    
Number of Shares Underlying Warrants [4] 1,002,507    
[1] Issued on March 15, 2017 in connection with the JGB Debt. As a result of the issuance of 1,022,544 shares of the Company’s common stock at $1.12 in connection with the amendments to the Conditional Share Purchase Agreement, the number of shares issuable pursuant to the JGB Warrants increased from 1,250,000 to 1,296,679 and the exercise price of the JGB Warrants was adjusted from $5.00 to $4.82, effective July 3, 2017. As a result of the 2017 Public Offering, effective October 5, 2017, the aggregate number of shares of common stock issuable upon exercise of the JGB Warrants increased from 1,296,679 to 1,338,326 shares and the exercise price of the JGB Warrants decreased from $4.82 to $4.67 per share.
[2] Issued on April 14, 2016 in connection with the private placement to certain accredited investors. In accordance with the anti-dilution provisions, the exercise price of the warrants issued in connection with such private placement was adjusted from $4.98 to $4.00, which was the price paid by investors in the Company’s underwritten public offering of common stock, which closed on September 26, 2016. As a result of the issuance of 1,022,544 shares of the Company’s common stock at $1.12 in connection with the amendments to the Conditional Share Purchase Agreement, the exercise price was adjusted from $4.00 to $1.12, effective July 3, 2017.
[3] Issued on April 14, 2016 in connection with the private placement to placement agents. As a result of the issuance of 1,022,544 shares of the Company’s common stock at $1.12 in connection with the amendments to the Conditional Share Purchase Agreement, the exercise price was adjusted from $3.99 to $1.12, effective July 3, 2017.
[4] Issued on June 15, 2016 in connection with a subsequent private placement. In accordance with the anti-dilution provisions, the exercise price of the warrants issued in connection with the subsequent private placement was adjusted from $4.98 per share to $4.00 per share, which was the price paid by investors in the Company’s underwritten public offering of common stock, which closed on September 26, 2016. The exercise price remained at $4.00 as the anti-dilution provision was waived for the issuance of shares related to the July 3, 2017 amendment to the Conditional Share Purchase Agreements.