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Stock Incentive Plans - Summary of Option, Unvested RSU Activity under 2014 Equity Incentive Plan and 2016 Inducement Equity Incentive Plan and Related Information (Detail)
 3 Months Ended
Mar. 31, 2023
$ / shares
shares
Shares Available for Grant  
Shares available for grant beginning balance (in shares) 1,490,462
Additional options authorized (in shares) 2,141,330
Common stock awards for services (in shares) (7,649)
RSUs granted (in shares) (1,262,588)
Options granted (in shares) (418,564)
Repurchase of common stock under employee incentive plans (in shares) 50,254
RSUs forfeited (in shares) 91,291
Options forfeited (in shares) 12,949
Options expired (in shares) 78,024
Shares available for grant ending balance (in shares) 2,175,509
Stock Options Outstanding  
Stock options outstanding beginning balance (in shares) 2,921,925
Stock options granted (in shares) 418,564
Stock options exercised (in shares) (820)
Stock options forfeited (in shares) (12,949)
Stock options expired (in shares) (78,024)
Stock options outstanding ending balance (in shares) 3,248,696
Weighted- Average Exercise Price  
Weighted average exercise price beginning balance (in dollars per share) | $ / shares $ 28.13
Weighted average exercise price - options granted (in dollars per share) | $ / shares 15.50
Weighted average exercise price - options exercised (in dollars per share) | $ / shares 2.06
Weighted average exercise price - options forfeited (in dollars per share) | $ / shares 31.32
Weighted average exercise price - options expired (in dollars per share) | $ / shares 33.81
Weighted average exercise price ending balance (in dollars per share) | $ / shares $ 26.52
Number of RSU Shares  
RSUs granted (in shares) 1,262,588
RSUs forfeited (in shares) (91,291)
Restricted Stock Units  
Shares Available for Grant  
RSUs granted (in shares) (1,262,588)
RSUs forfeited (in shares) 91,291
Number of RSU Shares  
Number of RSU shares beginning balance (in shares) 3,094,396
RSUs granted (in shares) 1,262,588
RSUs vested (in shares) (170,077)
RSUs forfeited (in shares) (91,291)
Number of RSU shares ending balance (in shares) 4,095,616
Weighted- Average Grant Date Fair Value  
Weighted average grant date fair value beginning balance (in dollars per share) | $ / shares $ 37.39
Weighted average grant date fair value - RSUs granted (in dollars per share) | $ / shares 15.27
Weighted average grant date fair value - RSUs vested (in dollars per share) | $ / shares 52.76
Weighted average grant date fair value - RSUs forfeited (in dollars per share) | $ / shares 36.78
Weighted average grant date fair value ending balance (in dollars per share) | $ / shares $ 29.87