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Stock Incentive Plans | 12 Months Ended
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Dec. 31, 2024
Share-Based Payment Arrangement [Abstract] |
Stock Incentive Plans | STOCK INCENTIVE PLANS 2014 Equity Incentive Plan The Company grants stock-based awards under its 2014 Equity Incentive Plan (the “2014 Plan”) that allows for issuance of stock options, restricted stock units (“RSUs”) and other stock awards to the Company’s employees, directors, and consultants. Stock options granted under the 2014 Plan may be exercised when vested and generally expire 10 years from the date of the grant or three months from the date of termination of employment. Vesting periods vary based on awards granted, however; certain stock-based awards may vest immediately or may accelerate based on performance-driven measures. Stock option awards generally vest over four years with a one-year cliff. The RSUs generally vest annually over four years in equal increments. There were 1,398,171 shares of common stock reserved for future issuance under the 2014 Plan as of December 31, 2024. 2016 Inducement Plan On April 21, 2016, the Company adopted the 2016 Inducement Equity Incentive Plan (the “2016 Plan”), that allows for the issuance of stock options, RSUs and other stock awards of up to a total of 155,500 shares of common stock to new employees of the Company. The 2016 Plan was adopted to accommodate a reserve of additional shares of common stock for issuance to new employees hired by the Company from Allenex AB. The terms in the 2016 Plan are substantially similar to the 2014 Plan. There were 62,752 shares of common stock reserved for future issuance under the 2016 Plan as of December 31, 2024. 2019 Inducement Equity Incentive Plan The Company grants stock-based awards under the 2019 Inducement Equity Incentive Plan (the “2019 Plan”) that allows for the issuance of stock options, RSUs and other stock awards to new employees of the Company. The terms in the 2019 Plan are substantially similar to the 2014 Plan. There were 35,084 shares of common stock reserved for future issuance under the 2019 Plan as of December 31, 2024. 2024 Equity Incentive Plan The Company grants stock-based awards under the 2024 Equity Incentive Plan (the “2024 Plan”) that allows for the issuance of stock options, RSUs and other stock awards to the Company’s employees, directors, and consultants. The terms in the 2024 Plan are substantially similar to the 2014 Plan. There were 3,063,094 shares of common stock reserved for future issuance under the 2024 Plan as of December 31, 2024. The Inducement Grants On April 15, 2024 and September 12, 2024, the Company granted a total of 1,487,326 shares of stock options and RSUs for the appointment of certain executive officers (the “Inducement Grants”). The Inducement Grants were approved by the Compensation Committee of the Company's Board of Directors as an inducement material to the employee's acceptance of employment with the Company in compliance with and in reliance on Nasdaq Listing Rule 5635(c)(4), which exempts employment grants from the general requirement of the Nasdaq Listing Rules that equity-based compensation plans and arrangements be approved by stockholders. Stock Options and RSUs The following table summarizes option and RSUs activity under the Company’s 2014 Plan, 2016 Plan, 2019 Plan and 2024 Plan, and related information:
| Shares Available for Grant |  | Stock Options Outstanding |  | Weighted- Average Exercise Price |  | Number of RSU Shares |  | Weighted- Average Grant Date Fair Value
Balance—December 31, 2023 | 869,111 |  |  | 3,055,208 |  |  | $ | 25.21 |  |  | 5,006,775 |  |  | $ | 19.02 |
Additional options authorized | 7,047,461 |  |  | — |  |  | — |  |  | — |  |  | — |
Common stock awards for services | (16,582) |  |  | — |  |  | — |  |  | — |  |  | — |
RSUs granted | (3,726,419) |  |  | — |  |  | — |  |  | 3,726,419 |  |  | 11.12 |
RSUs vested | — |  |  | — |  |  | — |  |  | (3,245,483) |  |  | 16.41 |
Options granted | (1,053,285) |  |  | 1,053,285 |  |  | 13.14 |  |  | — |  |  | — |
Options exercised | — |  |  | (527,009) |  |  | 16.96 |  |  | — |  |  | — |
Repurchases of common stock under employee incentive plans | 622,202 |  |  | — |  |  | — |  |  | — |  |  | — |
RSUs forfeited | 645,041 |  |  | — |  |  | — |  |  | (645,041) |  |  | 15.61 |
Options forfeited | 32,481 |  |  | (32,481) |  |  | 29.87 |  |  | — |  |  | — |
Options expired | 139,091 |  |  | (139,091) |  |  | 27.19 |  |  | — |  |  | — |
Balance—December 31, 2024 | 4,559,101 |  |  | 3,409,912 |  |  | $ | 22.63 |  |  | 4,842,670 |  |  | $ | 15.38 |
The total intrinsic value of options exercised was $4.8 million, $0.1 million and $1.6 million for the years ended December 31, 2024, 2023 and 2022, respectively. The total fair value of RSUs vested during 2024 was $62.0 million. As of December 31, 2024, the total intrinsic value of outstanding RSUs was approximately $107.3 million and there were $38.0 million of unrecognized compensation costs related to RSUs, which are expected to be recognized over a weighted-average period of 2.12 years. The Company granted performance restricted stock units ("PSUs"), included in RSUs, under the 2014 Plan. The PSUs granted to employees consist of financial and operational metrics to be met over a performance period of two years. The number of shares outstanding was 335,583 and 449,983 as of December 31, 2024 and December 31, 2023, respectively. The weighted-average remaining recognition period was 1.07 years and 1.01 years for the years ended December 31, 2024 and 2023, respectively. Options outstanding that have vested and are expected to vest at December 31, 2024 are as follows:
| Number of Options Issued (In thousands) |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Life (Years) |  | Aggregate Intrinsic Value (In thousands)
Vested | 2,075 |  |  | $ | 26.76 |  |  | 5.04 |  | $ | 6,512 |
Expected to Vest | 1,172 |  |  | 16.16 |  |  | 8.89 |  | 9,133 |
Total | 3,247 |  |  |  |  |  |  | $ | 15,645 |
The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying stock options and the fair value of the Company’s common stock at December 31, 2024 for stock options that were in-the-money. The weighted-average grant-date fair value of options to purchase common stock granted for the years ended December 31, 2024, 2023 and 2022 using the Black-Scholes Model was $9.08, $8.63 and $19.51, respectively. The total fair value of options that vested during 2024 was $11.6 million. As of December 31, 2024, there were approximately $11.8 million of unrecognized compensation costs related to stock options, which are expected to be recognized over a weighted-average period of 2.72 years. 2014 Employee Stock Purchase Plan The Company has an Employee Stock Purchase Plan (the “ESPP”), under which employees can purchase shares of its common stock-based on a percentage of their compensation, but not greater than 15% of their earnings; provided, however, an eligible employee’s right to purchase shares of the Company’s common stock may not accrue at a rate which exceeds $25,000 of the fair market value of such shares for each calendar year in which such rights are outstanding. The ESPP has consecutive offering periods of approximately six months in length. The purchase price per share must be equal to the lower of 85% of the fair value of the common stock on the first day of the offering period or on the exercise date. During the offering period in 2024 that ended on December 31, 2024, 66,747 shares were purchased for aggregate proceeds of $0.9 million from the issuance of shares, which occurred on January 2, 2025. During the offering period in 2024 that ended on June 30, 2024, 85,260 shares were purchased for aggregate proceeds of $0.9 million from the issuance of shares, which occurred on July 2, 2024. During the offering period in 2023 that ended on December 31, 2023, 73,759 shares were purchased for aggregate proceeds of $0.5 million from the issuance of shares, which occurred on January 2, 2024. The Company issued 159,019 shares and 190,842 shares of common stock during the years ended December 31, 2024 and December 31, 2023, respectively, pursuant to the ESPP. The Company received proceeds of $1.4 million and $1.5 million from the purchases of shares during the years ended December 31, 2024 and 2023, respectively. As of December 31, 2024, the Company had 558,787 shares available for issuance under the ESPP. Board of Directors Stock Awards Granted for Services For the years ended December 31, 2024, 2023 and 2022, the Company paid a portion of its directors’ compensation through the award of fully vested common shares. The stock awards are classified as equity, and compensation expense was recognized upon the issuance of the shares at the grant date price per share, which is the fair value. As of December 31, 2024, there were a total of 321,234 shares issued to the Company’s directors, for a total fair value of $2.6 million. Stock-based compensation expense associated with the awards was $0.1 million, $0.2 million and $0.4 million for the years ended December 31, 2024, 2023 and 2022, respectively, which was included in general and administrative expense on the consolidated statements of operations. Valuation Assumptions The estimated fair values of employee stock options and ESPP shares were estimated using the Black-Scholes option pricing model based on the following weighted average assumptions:
| Year Ended December 31,
| 2024 |  | 2023 |  | 2022
Employee stock options |  |  |  |  |
Expected term (in years) | 5.90 |  | 5.61 |  | 5.96
Expected volatility | 76.83 | % |  | 77.86 | % |  | 77.62 | %
Risk-free interest rate | 4.38 | % |  | 3.67 | % |  | 2.74 | %
Expected dividend yield | — | % |  | — | % |  | — | %
Employee stock purchase plan |  |  |  |  |
Expected term (in years) | 0.5 |  | 0.5 |  | 0.5
Expected volatility | 69.60% – 91.99% |  | 75.91% – 93.38% |  | 67.79% – 77.88%
Risk-free interest rate | 5.24% – 5.37% |  | 5.26% – 5.47% |  | 2.51% – 4.76%
Expected dividend yield | — | % |  | — | % |  | — | %
Risk-free Interest Rate: The Company based the risk-free interest rate over the expected term of the award based on the constant maturity rate of U.S. Treasury securities with similar maturities as of the date of grant. Volatility: The Company used an average historical stock price volatility of its own stock. Expected Term: The expected term represents the period for which the Company’s stock-based compensation awards are expected to be outstanding and is based on analyzing the vesting and contractual terms of the awards and the holders’ historical exercise patterns and termination behavior. Expected Dividends: The Company has not paid and does not anticipate paying any dividends in the near future. Stock-Based Compensation Expense The following table summarizes stock-based compensation expense relating to employee and nonemployee stock-based awards for the years ended December 31, 2024, 2023 and 2022, included on the consolidated statements of operations as follows (in thousands):
| Year Ended December 31,
| 2024 |  | 2023 |  | 2022
Cost of testing services | $ | 1,560 |  |  | $ | 1,854 |  |  | $ | 1,529 |
Cost of product | 870 |  |  | 1,165 |  |  | 1,120 |
Cost of patient and digital solutions | 1,276 |  |  | 1,377 |  |  | 1,331 |
Research and development | 6,501 |  |  | 6,556 |  |  | 7,391 |
Sales and marketing | 11,035 |  |  | 12,470 |  |  | 14,403 |
General and administrative | 45,164 |  |  | 25,664 |  |  | 20,779 |
Total | $ | 66,406 |  |  | $ | 49,086 |  |  | $ | 46,553 |

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