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Stock Incentive Plans (Tables) | 12 Months Ended
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Dec. 31, 2024
Share-Based Payment Arrangement [Abstract] |
Summary of Options, RSUs Activity under 2014 Equity Incentive Plan and 2016 Inducement Plan and Related Information | The following table summarizes option and RSUs activity under the Company’s 2014 Plan, 2016 Plan, 2019 Plan and 2024 Plan, and related information:
| Shares Available for Grant |  | Stock Options Outstanding |  | Weighted- Average Exercise Price |  | Number of RSU Shares |  | Weighted- Average Grant Date Fair Value
Balance—December 31, 2023 | 869,111 |  |  | 3,055,208 |  |  | $ | 25.21 |  |  | 5,006,775 |  |  | $ | 19.02 |
Additional options authorized | 7,047,461 |  |  | — |  |  | — |  |  | — |  |  | — |
Common stock awards for services | (16,582) |  |  | — |  |  | — |  |  | — |  |  | — |
RSUs granted | (3,726,419) |  |  | — |  |  | — |  |  | 3,726,419 |  |  | 11.12 |
RSUs vested | — |  |  | — |  |  | — |  |  | (3,245,483) |  |  | 16.41 |
Options granted | (1,053,285) |  |  | 1,053,285 |  |  | 13.14 |  |  | — |  |  | — |
Options exercised | — |  |  | (527,009) |  |  | 16.96 |  |  | — |  |  | — |
Repurchases of common stock under employee incentive plans | 622,202 |  |  | — |  |  | — |  |  | — |  |  | — |
RSUs forfeited | 645,041 |  |  | — |  |  | — |  |  | (645,041) |  |  | 15.61 |
Options forfeited | 32,481 |  |  | (32,481) |  |  | 29.87 |  |  | — |  |  | — |
Options expired | 139,091 |  |  | (139,091) |  |  | 27.19 |  |  | — |  |  | — |
Balance—December 31, 2024 | 4,559,101 |  |  | 3,409,912 |  |  | $ | 22.63 |  |  | 4,842,670 |  |  | $ | 15.38 |
Summary of Options Outstanding and Exercisable Vested or Expected to Vest | Options outstanding that have vested and are expected to vest at December 31, 2024 are as follows:
| Number of Options Issued (In thousands) |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Life (Years) |  | Aggregate Intrinsic Value (In thousands)
Vested | 2,075 |  |  | $ | 26.76 |  |  | 5.04 |  | $ | 6,512 |
Expected to Vest | 1,172 |  |  | 16.16 |  |  | 8.89 |  | 9,133 |
Total | 3,247 |  |  |  |  |  |  | $ | 15,645 |
Summary of Weighted-Average Assumptions Used to Estimate Fair Value of Share-Based Awards | The estimated fair values of employee stock options and ESPP shares were estimated using the Black-Scholes option pricing model based on the following weighted average assumptions:
| Year Ended December 31,
| 2024 |  | 2023 |  | 2022
Employee stock options |  |  |  |  |
Expected term (in years) | 5.90 |  | 5.61 |  | 5.96
Expected volatility | 76.83 | % |  | 77.86 | % |  | 77.62 | %
Risk-free interest rate | 4.38 | % |  | 3.67 | % |  | 2.74 | %
Expected dividend yield | — | % |  | — | % |  | — | %
Employee stock purchase plan |  |  |  |  |
Expected term (in years) | 0.5 |  | 0.5 |  | 0.5
Expected volatility | 69.60% – 91.99% |  | 75.91% – 93.38% |  | 67.79% – 77.88%
Risk-free interest rate | 5.24% – 5.37% |  | 5.26% – 5.47% |  | 2.51% – 4.76%
Expected dividend yield | — | % |  | — | % |  | — | %
Summary of Expense Relating to Employee and Nonemployee Stock-Based Payment Awards from Stock Options and RSUs | The following table summarizes stock-based compensation expense relating to employee and nonemployee stock-based awards for the years ended December 31, 2024, 2023 and 2022, included on the consolidated statements of operations as follows (in thousands):
| Year Ended December 31,
| 2024 |  | 2023 |  | 2022
Cost of testing services | $ | 1,560 |  |  | $ | 1,854 |  |  | $ | 1,529 |
Cost of product | 870 |  |  | 1,165 |  |  | 1,120 |
Cost of patient and digital solutions | 1,276 |  |  | 1,377 |  |  | 1,331 |
Research and development | 6,501 |  |  | 6,556 |  |  | 7,391 |
Sales and marketing | 11,035 |  |  | 12,470 |  |  | 14,403 |
General and administrative | 45,164 |  |  | 25,664 |  |  | 20,779 |
Total | $ | 66,406 |  |  | $ | 49,086 |  |  | $ | 46,553 |

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- Definition Tabular disclosure of number, weighted-average exercise price or conversion ratio, aggregate intrinsic value, and weighted-average remaining contractual term for outstanding options that are fully vested and expected to vest. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (e)(1) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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