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Stock Incentive Plans (Tables)
 12 Months Ended
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Summary of Options, RSUs Activity under 2014 Equity Incentive Plan and 2016 Inducement Plan and Related Information
The following table summarizes option and RSUs activity under the Company’s 2014 Plan, 2016 Plan, 2019 Plan and 2024 Plan, and related information:
Shares
Available
for Grant
Stock
Options
Outstanding
Weighted-
Average
Exercise
Price
Number of
RSU Shares
Weighted-
Average
Grant Date
Fair Value
Balance—December 31, 2023869,111 3,055,208 $25.21 5,006,775 $19.02 
Additional options authorized7,047,461 — — — — 
Common stock awards for services(16,582)— — — — 
RSUs granted(3,726,419)— — 3,726,419 11.12 
RSUs vested— — — (3,245,483)16.41 
Options granted(1,053,285)1,053,285 13.14 — — 
Options exercised— (527,009)16.96 — — 
Repurchases of common stock under employee incentive plans622,202 — — — — 
RSUs forfeited645,041 — — (645,041)15.61 
Options forfeited32,481 (32,481)29.87 — — 
Options expired139,091 (139,091)27.19 — — 
Balance—December 31, 20244,559,101 3,409,912 $22.63 4,842,670 $15.38 
Summary of Options Outstanding and Exercisable Vested or Expected to Vest
Options outstanding that have vested and are expected to vest at December 31, 2024 are as follows:
Number of
Options Issued (In thousands)
Weighted Average Exercise
Price
Weighted
Average
Remaining
Contractual Life
(Years)
Aggregate
Intrinsic Value
(In thousands)
Vested2,075 $26.76 5.04$6,512 
Expected to Vest1,172 16.16 8.899,133 
Total3,247 $15,645 
Summary of Weighted-Average Assumptions Used to Estimate Fair Value of Share-Based Awards
The estimated fair values of employee stock options and ESPP shares were estimated using the Black-Scholes option pricing model based on the following weighted average assumptions:
Year Ended December 31,
202420232022
Employee stock options
Expected term (in years)5.905.615.96
Expected volatility76.83 %77.86 %77.62 %
Risk-free interest rate4.38 %3.67 %2.74 %
Expected dividend yield— %— %— %
Employee stock purchase plan
Expected term (in years)0.50.50.5
Expected volatility
69.60% – 91.99%
75.91% – 93.38%
67.79% – 77.88%
Risk-free interest rate
5.24% – 5.37%
5.26% – 5.47%
2.51% – 4.76%
Expected dividend yield— %— %— %
Summary of Expense Relating to Employee and Nonemployee Stock-Based Payment Awards from Stock Options and RSUs
The following table summarizes stock-based compensation expense relating to employee and nonemployee stock-based awards for the years ended December 31, 2024, 2023 and 2022, included on the consolidated statements of operations as follows (in thousands):
Year Ended December 31,
202420232022
Cost of testing services$1,560 $1,854 $1,529 
Cost of product870 1,165 1,120 
Cost of patient and digital solutions1,276 1,377 1,331 
Research and development6,501 6,556 7,391 
Sales and marketing11,035 12,470 14,403 
General and administrative45,164 25,664 20,779 
Total$66,406 $49,086 $46,553