<SEC-DOCUMENT>0001415889-25-021035.txt : 20250805
<SEC-HEADER>0001415889-25-021035.hdr.sgml : 20250805
<ACCEPTANCE-DATETIME>20250805162935
ACCESSION NUMBER:		0001415889-25-021035
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20250801
FILED AS OF DATE:		20250805
DATE AS OF CHANGE:		20250805

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Novack Jeffrey Adam
		CENTRAL INDEX KEY:			0002019976
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36536
		FILM NUMBER:		251185402

	MAIL ADDRESS:	
		STREET 1:		8000 MARINA BOULEVARD
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CareDx, Inc.
		CENTRAL INDEX KEY:			0001217234
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				943316839
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8000 MARINA BLVD
		STREET 2:		4TH FLOOR
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		415-287-2300

	MAIL ADDRESS:	
		STREET 1:		8000 MARINA BLVD
		STREET 2:		4TH FLOOR
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	XDx, Inc.
		DATE OF NAME CHANGE:	20071010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXPRESSION DIAGNOSTICS INC
		DATE OF NAME CHANGE:	20030203
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4-08052025_080832.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-08-01</periodOfReport>

    <issuer>
        <issuerCik>0001217234</issuerCik>
        <issuerName>CareDx, Inc.</issuerName>
        <issuerTradingSymbol>CDNA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002019976</rptOwnerCik>
            <rptOwnerName>Novack Jeffrey Adam</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAREDX, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>8000 MARINA BOULEVARD</rptOwnerStreet2>
            <rptOwnerCity>BRISBANE</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94005</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Secretary and General Counsel</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-08-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2873</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.22</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>115618</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">These shares were withheld by the Issuer in order to satisfy certain tax withholding obligations in connection with the issuance of shares upon the vesting of restricted stock units.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jeffrey Adam Novack</signatureName>
        <signatureDate>2025-08-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-08052025_080834.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex24-08052025_080834.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin:0px"><br></p>
<p style="margin:0px; padding-right:0.533px; font-size:11pt" align="center"><b>POWER OF ATTORNEY</b></p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin-top:8px; margin-bottom:8px; padding-right:0.533px; text-indent:48px; font-size:11pt" align="justify">KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and appoints Colleen Martin-Garcia and Abhishek Jain, and each of them, her true and lawful attorney-in-fact to:</p>
<p style="margin-top:8px;margin-bottom:-1pt;font-size:1pt"></p><p style="margin-top:0px; margin-bottom:-2px; text-indent:47.933px; width:96.467px; font-size:11pt; float:left">(1)</p>
<p style="margin-top:0px; margin-bottom:8px; padding-left:96.467px; text-indent:-2px; font-size:11pt">Execute for an on behalf of the undersigned, in the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s capacity as a representative of CareDx, Inc. (the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font>Company<font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), any and all Form 3, 4 or 5 reports required to be filed by the undersigned in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended (<font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font>Exchange Act<font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), and the rules thereunder with respect to transactions in securities of the Company;</p>
<p style="margin-top:8px;margin-bottom:-1pt;font-size:1pt"></p><p style="margin-top:0px; margin-bottom:-2px; text-indent:47.933px; width:96.467px; font-size:11pt; clear:left; float:left">(2)</p>
<p style="margin-top:0px; margin-bottom:8px; padding-left:96.467px; padding-right:0.6px; text-indent:-2px; font-size:11pt" align="justify">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4 or 5 report and timely file such report with the U.S. Securities and Exchange Commission and any stock exchange or similar authority; and</p>
<p style="margin-top:8px;margin-bottom:-1pt;font-size:1pt"></p><p style="margin-top:0px; margin-bottom:-2px; text-indent:47.933px; width:96.467px; font-size:11pt; clear:left; float:left">(3)</p>
<p style="margin-top:0px; margin-bottom:8px; padding-left:96.467px; padding-right:0.267px; text-indent:-2px; font-size:11pt" align="justify">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned, pursuant to this Power of Attorney, shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in her/his discretion.</p>
<p style="margin-top:8px; margin-bottom:8px; text-indent:48px; font-size:11pt; clear:left" align="justify">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform each and every act and thing whatsoever requisite, necessary and proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or her/his substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights and powers herein granted. The undersigned acknowledges that no such attorney-in-fact, in serving in such capacity at the request of the undersigned, is hereby assuming, nor is the Company hereby assuming, any of the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s responsibilities to comply with Section 16 of the Exchange Act.</p>
<p style="margin-top:8px; margin-bottom:8px; text-indent:48px; font-size:11pt" align="justify">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Form 3, 4 or 5 reports with respect to the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s holdings of an transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.</p>
<p style="margin-top:8px; margin-bottom:8px; padding-right:0.733px; text-indent:48px; font-size:11pt" align="justify">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of July 15, 2025.</p>
<p style="margin:8px" align="justify"><br></p>
<p style="margin-top:8px; margin-bottom:8px; padding-right:0.733px; text-indent:48px; font-size:11pt" align="justify"><u>/s/ Jeffrey Adam Novack</u></p>
<p style="margin-top:8px; margin-bottom:8px; padding-right:0.733px; text-indent:48px; font-size:11pt" align="justify">Jeffrey Adam Novack</p>
<p style="margin:8px" align="justify"><br><br></p>
<p style="margin:0px"><br></p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
