<SEC-DOCUMENT>0001415889-25-021430.txt : 20250811
<SEC-HEADER>0001415889-25-021430.hdr.sgml : 20250811
<ACCEPTANCE-DATETIME>20250811163416
ACCESSION NUMBER:		0001415889-25-021430
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20250807
FILED AS OF DATE:		20250811
DATE AS OF CHANGE:		20250811

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SMITH NATHAN
		CENTRAL INDEX KEY:			0002079385
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36536
		FILM NUMBER:		251202522

	MAIL ADDRESS:	
		STREET 1:		C/O CAREDX, INC.
		STREET 2:		8000 MARINA BLVD, 4TH FLOOR
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CareDx, Inc.
		CENTRAL INDEX KEY:			0001217234
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				943316839
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8000 MARINA BLVD
		STREET 2:		4TH FLOOR
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		415-287-2300

	MAIL ADDRESS:	
		STREET 1:		8000 MARINA BLVD
		STREET 2:		4TH FLOOR
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	XDx, Inc.
		DATE OF NAME CHANGE:	20071010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXPRESSION DIAGNOSTICS INC
		DATE OF NAME CHANGE:	20030203
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3-08112025_080807.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-08-07</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001217234</issuerCik>
        <issuerName>CareDx, Inc.</issuerName>
        <issuerTradingSymbol>CDNA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002079385</rptOwnerCik>
            <rptOwnerName>SMITH NATHAN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAREDX, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>8000 MARINA BLVD., 4TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BRISBANE</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94005</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <ownerSignature>
        <signatureName>/s/ Jeffrey Adam Novack, Attorney-in-Fact</signatureName>
        <signatureDate>2025-08-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-08112025_080810.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex24-08112025_080810.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin-top:7.667px; margin-bottom:7.667px; padding-left:15.333px; font-size:10.5pt" align="center"><b>POWER OF ATTORNEY</b></p>
<p style="margin:8px"><br></p>
<p style="margin:8px"><br></p>
<p style="margin-top:8px; margin-bottom:8px; padding-left:19.733px; padding-right:3.733px; text-indent:48px; font-size:10.5pt" align="justify">KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and appoints Adil Aslam, Jeff Novack, Colleen Martin-Garcia and Chande Chang, and each of them, her true and lawful attorney-in-fact to:</p>
<p style="margin-top:8px;margin-bottom:-1pt;font-size:1pt"></p><p style="margin-top:0px; margin-bottom:-2px; text-indent:24px; width:48px; font-size:10.5pt; float:left">1)</p>
<p style="margin-top:0px; margin-bottom:8px; padding-left:48px; padding-right:3.733px; text-indent:-2px; font-size:10.5pt" align="justify">execute for and on behalf of the undersigned, in the undersigned's capacity as a representative of CareDx, Inc. (the <b>"Company"), </b>any and all Form 3, 4 or 5 repotts required to be filed by the undersigned in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended <b>("Exchange Act"), </b>and the rules thereunder with respect to transactions in securities of the Company;</p>
<p style="margin-top:7.667px;margin-bottom:-1pt;font-size:1pt"></p><p style="margin-top:0px; margin-bottom:-2px; text-indent:24px; width:48px; font-size:11pt; clear:left; float:left">2)</p>
<p style="margin-top:0px; margin-bottom:7.667px; padding-left:48px; padding-right:3.333px; text-indent:-2px; font-size:10.5pt" align="justify">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4 or 5 report and timely file such report with the U.S. Securities and Exchange Commission and any stock exchange or similar authority; and</p>
<p style="margin-top:7.667px;margin-bottom:-1pt;font-size:1pt"></p><p style="margin-top:0px; margin-bottom:-2px; text-indent:24px; width:48px; font-size:11pt; clear:left; float:left">3)</p>
<p style="margin-top:0px; margin-bottom:7.667px; padding-left:48px; padding-right:3.733px; text-indent:-2px; font-size:10.5pt" align="justify">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned, pursuant to this Power of Attorney, shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in her/his discretion.</p>
<p style="margin-top:8px; margin-bottom:8px; padding-left:18.8px; padding-right:4px; text-indent:48.067px; font-size:10.5pt; clear:left" align="justify">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform each and every act and thing whatsoever requisite, necessary and proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or her/his substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights and powers herein granted. The undersigned acknowledges that no such attorney-in-fact, in serving in such capacity at the request of the undersigned, is hereby assuming, nor is the Company hereby assuming, any of the undersigned's responsibilities to comply with Section 16 of the Exchange Act.</p>
<p style="margin-top:8px; margin-bottom:8px; padding-left:18.2px; padding-right:4.867px; text-indent:48.4px; font-size:10.5pt" align="justify">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Form 3, 4 or 5 reports with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.</p>
<p style="margin-top:9.133px; margin-bottom:9.133px; padding-left:18.267px; padding-right:4.8px; text-indent:48px; font-size:12pt">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of July 17, 2025.</p>
<p style="margin:8px"><br></p>
<p style="margin:8px"><br></p>
<p style="margin:0px; padding-left:353.933px; font-size:10.5pt"><u>/s/ Nathan Smith</u></p>
<p style="margin-top:8px; margin-bottom:8px; padding-left:353.933px; font-size:10.5pt">Nathan Smith</p>
<p style="margin:8px"><br></p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
