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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Pay vs Performance Disclosure |  |  |  |  |
Pay vs Performance Disclosure, Table |
|  |  |  |  |  |  |  |  |  |  | Value of Initial Fixed $100 Investment Based On: |  |
Fiscal Year (a) | Summary Compensa tion Table (“SCT”) for Mr. Hanna (PEO 1) (b)(1) | CAP to Mr. Hanna (PEO 1) (c)(2) | Summary Compensa tion Table (“SCT”) for Mr. Johnson (PEO 2) (d)(1) | CAP to Mr. Johnson (PEO 2) (e)(2) | SCT for Dr. Seeto (PEO 3) (f)(1) | CAP to Dr. Seeto (PEO 3) (g)(2) | SCT for Dr. Maag (PEO 4) (h)(1) | CAP to Dr. Maag (PEO 4) (i)(2) | Average SCT for Non- PEO NEOs (j)(3) | Average CAP to Non- PEO NEOs (k)(2) | Net Income (in thousands ) (n) | Revenue (in thousand s) (o)(5)
TSR (l)(4) | Peer Group TSR (m)(4)
2024 | $9,424,329 | $24,178,001 | $2,937,571 | $7,443,241 | — | — | — | — | $2,986,074 | $3,772,296 | $99.26 | $118.20 | $52,549 | $333,785
2023 | — | — | $3,097,438 | $1,923,573 | $10,551,753 | $6,665,898 | — | — | $4,617,844 | $4,412,835 | $55.63 | $118.87 | ($190,284) | $280,324
2022 | — | — | — | — | $12,786,270 | ($648,097) | — | — | $3,784,612 | $118,224 | $52.90 | $113.65 | ($76,613) | $321,793
2021 | — | — | — | — | $7,090,121 | ($50,411) | — | — | $2,605,699 | $140,603 | $210.85 | $126.45 | ($30,662) | $296,397
2020 | — | — | — | — | $5,618,698 | $17,196,016 | $6,400,015 | $32,731,502 | $1,979,508 | $7,956,557 | $335.88 | $126.42 | ($18,714) | $192,194
Company Selected Measure Name | Revenue |  |  |  |
Named Executive Officers, Footnote | The dollar amounts reported in columns (b), (d), and (f) are the amounts of total compensation reported for Mr. Johnson (our Principal Executive Officer since November 1, 2023), Dr. Seeto (Chief Executive Officer and Principal Executive Officer from November 1, 2020 to November 1, 2023) and Dr. Maag (Chief Executive Officer until November 1, 2020) for each corresponding year in the “Total” column of the Summary Compensation Table. Refer to the “Summary Compensation Table” on page 62 for additional information.
2024 | 2023 | 2022 | 2021 | 2020
Abhishek Jain | Abhishek Jain | Abhishek Jain | Ankur Dhingra | Michael Bell
Keith Kennedy | Abraham Ronai | Alexander Johnson | Alexander Johnson | Sasha King
Jessica Meng |  | Abraham Ronai | Sasha King | Marcel Konrad
Jeffrey Novack |  | Ankur Dhingra | Peter Maag, Ph. D. |
|  | Sasha King | Marcel Konrad |
Peer Group Issuers, Footnote | TSR is determined based on the value of an initial fixed investment of $100. The TSR peer group consists of the Nasdaq Biotech Index companies. TSR is calculated by dividing (i) the difference between the stock price at the end of each measurement period shown and the beginning of the measurement period by (ii) the stock price at the beginning of the measurement period. |  |  |  |
Adjustment To PEO Compensation, Footnote |
Fiscal Year | Executives | SCT (a) | Grant Date Value of New Awards (b) | Year End Value of New Awards (i) | Change in Value of Outstandin g Awards Granted in Prior Fiscal Year (ii) | Change in Value of Vested Awards Granted in Prior Fiscal Years (iii) | Fair Value of Vested Awards Granted and Vested in Current Fiscal Year (iv) | Fair Value at Start of Fiscal Year of Awards that Failed to Meet Vesting Condition s (v) | Value of Dividend s Paid on Equity Awards not Reflecte d in Fair Value (vi) | Total Equity CAP (c)=(i)+(ii)+ (iii)+(iv) | CAP (d)= (a)-(b)+(c)
2024 | PEO 1 | $9,424,329 | ($8,001,024) | $22,754,696 | $— | $— | — | — | — | $22,754,696 | $24,178,001
| PEO 2 | $2,937,571 | ($1,549,738) | $2,802,355 | $2,262,180 | $185,168 | 805,705 | — | — | $6,055,408 | $7,443,241
| Non-PEO NEO Avg | $2,986,074 | ($2,340,879) | $2,220,533 | $577,907 | $50,217 | 278,444 | — | — | $3,127,101 | $3,772,296
Non-PEO NEO Average Total Compensation Amount | $ 2,986,074 | $ 4,617,844 | $ 3,784,612 | $ 2,605,699 | $ 1,979,508
Non-PEO NEO Average Compensation Actually Paid Amount | $ 3,772,296 | 4,412,835 | 118,224 | 140,603 | 7,956,557
Adjustment to Non-PEO NEO Compensation Footnote |
Fiscal Year | Executives | SCT (a) | Grant Date Value of New Awards (b) | Year End Value of New Awards (i) | Change in Value of Outstandin g Awards Granted in Prior Fiscal Year (ii) | Change in Value of Vested Awards Granted in Prior Fiscal Years (iii) | Fair Value of Vested Awards Granted and Vested in Current Fiscal Year (iv) | Fair Value at Start of Fiscal Year of Awards that Failed to Meet Vesting Condition s (v) | Value of Dividend s Paid on Equity Awards not Reflecte d in Fair Value (vi) | Total Equity CAP (c)=(i)+(ii)+ (iii)+(iv) | CAP (d)= (a)-(b)+(c)
2024 | PEO 1 | $9,424,329 | ($8,001,024) | $22,754,696 | $— | $— | — | — | — | $22,754,696 | $24,178,001
| PEO 2 | $2,937,571 | ($1,549,738) | $2,802,355 | $2,262,180 | $185,168 | 805,705 | — | — | $6,055,408 | $7,443,241
| Non-PEO NEO Avg | $2,986,074 | ($2,340,879) | $2,220,533 | $577,907 | $50,217 | 278,444 | — | — | $3,127,101 | $3,772,296
Equity Valuation Assumption Difference, Footnote | The recalculated value of equity awards for each applicable year includes the addition (or subtraction, as applicable) of the following: (d)the year-end fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the applicable year; (e)the amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of any awards granted in prior years that are outstanding and unvested as of the end of the applicable year; (f)for awards that vest in the applicable year, the change in the fair value as of the vesting date from the beginning of the applicable year; (g)for awards that failed to meet vesting conditions in the applicable year, the fair value from the end of prior fiscal year. (h)for awards that failed to meet vesting conditions in the applicable year, the fair value from the end of prior fiscal year; (i)value of dividend not otherwise captured in the calculation of each Fair Value used to calculate CAP |  |  |  |
Compensation Actually Paid vs. Net Income | Char t 2 |  |  |  |
Compensation Actually Paid vs. Company Selected Measure | Chart 3 |  |  |  |
Total Shareholder Return Vs Peer Group | Chart 1 |  |  |  |
Tabular List, Table |
2024 Most Important Performance Measures The Compensation and Human Capital Committee uses a mix of performance measures throughout our annual and long-term incentive programs to align executive pay with Company performance. As required by SEC rules, the performance measures identified as the most important for all of our NEOs’ 2024 compensation decisions are listed in the table to the right. The measures in this table are not ranked. |  |
| Most Important Performance Measures
| Revenue
| Adjusted EBITDA
| Pipeline
Total Shareholder Return Amount | $ 99.26 | 55.63 | 52.90 | 210.85 | 335.88
Peer Group Total Shareholder Return Amount | 118.20 | 118.87 | 113.65 | 126.45 | 126.42
Net Income (Loss) | $ 52,549,000 | $ (190,284,000) | $ (76,613,000) | $ (30,662,000) | $ (18,714,000)
Company Selected Measure Amount | 333,785,000 | 280,324,000 | 321,793,000 | 296,397,000 | 192,194,000
PEO Name |  | Mr. Johnson | Dr. Seeto | Dr. Seeto | Dr. Maag
Additional 402(v) Disclosure | The dollar amounts reported in columns (c), (e), (g), (i), and (k) represent the amount of the CAP, as computed in accordance with SEC rules. The CAP does not necessarily represent cash and/or equity value transferred to the applicable NEO without restriction, but rather is a value calculated under applicable SEC rules. These amounts reflect the total amount of compensation for our NEOs reported in the Summary Compensation Table with certain adjustments as described in the table below for the most recent fiscal year. We do not have a defined benefit plan so no adjustment for pension benefits is included. The valuation assumptions and processes used to recalculate fair values did not materially differ from those disclosed at the time of grant. The dollar amounts reported in the Summary Compensation Table for the applicable year. (b)The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards” columns of the Summary Compensation Table for the applicable year. The CAP does not necessarily represent cash and/or equity value transferred to the applicable NEO without restriction, but rather is a value calculated under applicable SEC rules. The dollar amounts reported in column (j) are the average amounts of total compensation reported for the Non-PEO NEOs for each corresponding year in the “Total” column of the Summary Compensation Table. Refer to our “Summary Compensation Table” on page 62 for additional information. For each of fiscal years in the table, the Non-PEO NEOs were: We determined Revenue to be the most important financial performance measure used to link Company performance to the CAP to our PEOs and Non-PEO NEOs in 2024, consistent with the Total Sales targets used for our short-term incentives (annual bonuses) and long-term incentives (PRSUs). See page 50 of our CD&A for additional information. Relationship Between the CAP and Performance Measures We believe the table above shows the alignment between the CAP to the NEOs and the Company’s performance, consistent with our compensation philosophy as described in our CD&A beginning on page 50. The charts below show the relationship between the CAP to our PEOs and Non-PEO NEOs and (i) our TSR and the Peer Group TSR; (ii) our net income and (iii) our Company-Selected Measure, Revenue, during the five most recently completed fiscal years. |  |  |  |
Measure:: 1 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Revenue |  |  |  |
Measure:: 2 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Adjusted EBITDA |  |  |  |
Measure:: 3 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Pipeline |  |  |  |
Mr. John W. Hanna [Member] |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
PEO Total Compensation Amount | $ 9,424,329 |  |  |  |
PEO Actually Paid Compensation Amount | 24,178,001 |  |  |  |
Mr. Johnson [Member] |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
PEO Total Compensation Amount | 2,937,571 | $ 3,097,438 |  |  |
PEO Actually Paid Compensation Amount | 7,443,241 | 1,923,573 |  |  |
Dr. Seeto [Member] |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
PEO Total Compensation Amount |  | 10,551,753 | $ 12,786,270 | $ 7,090,121 | $ 5,618,698
PEO Actually Paid Compensation Amount |  | $ 6,665,898 | $ (648,097) | $ (50,411) | 17,196,016
Dr. Maag [Member] |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
PEO Total Compensation Amount |  |  |  |  | 6,400,015
PEO Actually Paid Compensation Amount |  |  |  |  | $ 32,731,502
PEO | Mr. John W. Hanna [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (8,001,024) |  |  |  |
PEO | Mr. John W. Hanna [Member] | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 22,754,696 |  |  |  |
PEO | Mr. John W. Hanna [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 22,754,696 |  |  |  |
PEO | Mr. John W. Hanna [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Mr. John W. Hanna [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Mr. John W. Hanna [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Mr. John W. Hanna [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Mr. John W. Hanna [Member] | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Mr. Johnson [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (1,549,738) |  |  |  |
PEO | Mr. Johnson [Member] | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 6,055,408 |  |  |  |
PEO | Mr. Johnson [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 2,802,355 |  |  |  |
PEO | Mr. Johnson [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 2,262,180 |  |  |  |
PEO | Mr. Johnson [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 805,705 |  |  |  |
PEO | Mr. Johnson [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 185,168 |  |  |  |
PEO | Mr. Johnson [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Mr. Johnson [Member] | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (2,340,879) |  |  |  |
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 3,127,101 |  |  |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 2,220,533 |  |  |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 577,907 |  |  |  |
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 278,444 |  |  |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 50,217 |  |  |  |
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ 0 |  |  |  |

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